- 2021
- Published
Inverse correlation of fluctuations of cerebral blood and water concentrations in humans
Borchardt, V., Korhonen, V., Helakari, H., Nedergaard, Maiken, Myllylä, T. & Kiviniemi, V., 2021, In: European Physical Journal Plus. 136, 5, 497.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lung megakaryocytes are immune modulatory cells
Pariser, D. N., Hilt, Z. T., Ture, S. K., Blick-Nitko, S. K., Looney, M. R., Cleary, S. J., Roman-Pagan, E., Saunders, J., Georas, S. N., Veazey, J., Madere, F., Santos, L. T., Arne, A., Huynh, N. P. T., Livada, A. C., Guerrero-Martin, S. M., Lyons, C., Metcalf-Pate, K. A., McGrath, K. E., Palis, J. & 1 others, , 2021, In: Journal of Clinical Investigation. 131, 1, e137377.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mapping of CSF transport using high spatiotemporal resolution dynamic contrast-enhanced MRI in mice: Effect of anesthesia
Stanton, E. H., Persson, N. D. Å., Gomolka, Ryszard Stefan, Lilius, T., Sigurðsson, B., Lee, H., L R Xavier, Anna , Benveniste, H., Nedergaard, Maiken & Mori, Yuki, 2021, In: Magnetic Resonance in Medicine. 85, 6, p. 3326-3342 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Measuring Shape Relations Using r-Parallel Sets
Stephensen, Hans Jacob Teglbjærg, Svane, A. M., Villanueva, C. B., Goldman, Steven Alan & Sporring, Jon, 2021, In: Journal of Mathematical Imaging and Vision. 63, p. 1069–1083 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
NREM sleep upregulates human brain pulsation detected by Ultrafast Magnetic Resonance Encephalography
Larsen, S. M. U., Holst, S. C., Olsen, A. S., Zilstorff, D. B., Pleinert, S., Kiviniemi, V., Jennum, Poul, Nedergaard, Maiken & Knudsen, Gitte Moos, 2021, In: European Neuropsychopharmacology. 53, p. S361-S362 3 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Not All Lectins Are Equally Suitable for Labeling Rodent Vasculature
Battistella, R., Kritsilis, M., Matuskova, H., Haswell, D., Cheng, A. X., Meissner, A., Nedergaard, Maiken & Lundgaard, I., 2021, In: International Journal of Molecular Sciences (Online). 22, 21, 11554.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Probing the polarity of spontaneous perisomatic GABAergic synaptic transmission in the mouse CA3 circuit in vivo
Dubanet, O., Da Silva, A. F. G., Frick, A., Hirase, Hajime, Beyeler, A. & Leinekugel, X., 2021, In: Cell Reports. 36, 2, 19 p., 109381.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
RIF1 and KAP1 differentially regulate the choice of inactive versus active X chromosomes
Enervald, E., Powell, L. M., Boteva, L., Foti, R., Blanes Ruiz, N., Kibar, G., Piszczek, A., Cavaleri, F., Vingron, M., Cerase, A. & Buonomo, S. B. C., 2021, In: EMBO Journal. 40, 22, 16 p., e105862 .Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reactive astrocyte nomenclature, definitions, and future directions
Escartin, C., Galea, E., Lakatos, A., O'Callaghan, J. P., Petzold, G. C., Serrano-Pozo, A., Steinhauser, C., Volterra, A., Carmignoto, G., Agarwal, A., Allen, N. J., Araque, A., Barbeito, L., Barzilai, A., Bergles, D. E., Bonvento, G., Butt, A. M., Chen, W-T., Cohen-Salmon, M., Cunningham, C. & 61 others, , 2021, In: Nature Neuroscience. 24, p. 312–325 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reply to: Rethink the classical view of cerebrospinal fluid production
Wardlaw, J. M., Benveniste, H., Nedergaard, Maiken, Zlokovic, B. V., Charpak, S., Smith, K. J. & Black, S. E., 2021, In: Nature Reviews Neurology. 17, 9, p. 590-591Research output: Contribution to journal › Letter › Research › peer-review
- Published
Spared Nerve Injury Causes Sexually Dimorphic Mechanical Allodynia and Differential Gene Expression in Spinal Cords and Dorsal Root Ganglia in Rats
Ahlstrom, F. H. G., Matlik, K., Viisanen, H., Blomqvist, K. J., Liu, X., Lilius, T. O., Sidorova, Y., Kalso, E. A. & Rauhala, P. V., 2021, In: Molecular Neurobiology. 58, p. 5396–5419 24 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Glymphatic System (En)during Inflammation
Mogensen, F. L., Delle, Christine & Nedergaard, Maiken, 2021, In: International Journal of Molecular Sciences. 22, 14, 20 p., 7491.Research output: Contribution to journal › Review › Research › peer-review
- Published
The Ser19Stop single nucleotide polymorphism (SNP) of human PHYHIPL affects the cerebellum in mice
Sugimoto, H., Horii, T., Hirota, J. N., Sano, Y., Shinoda, Y., Konno, A., Hirai, H., Ishizaki, Y., Hirase, Hajime, Hatada, I., Furuichi, T. & Sadakata, T., 2021, In: Molecular Brain. 14, 1, 9 p., 52.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The continued need for animals to advance brain research
Homberg, J. R., Adan, R. A. H., Alenina, N., Asiminas, A., Bader, M., Beckers, T., Begg, D. P., Blokland, A., Burger, M. E., van Dijk, G., Eisel, U. L. M., Elgersma, Y., Englitz, B., Fernandez-Ruiz, A., Fitzsimons, C. P., van Dam, A-M., Gass, P., Grandjean, J., Havekes, R., Henckens, M. J. A. G. & 54 others, , 2021, In: Neuron. 109, 15, p. 2374-2379 6 p.Research output: Contribution to journal › Editorial › Research › peer-review
- Published
The glymphatic system: A novel component of fundamental neurobiology
Hablitz, L. M. & Nedergaard, Maiken, 2021, In: Journal of Neuroscience. 41, 37, p. 7698-7711 14 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Transient Astrocytic Gq Signaling Underlies Remote Memory Enhancement
Iwai, Y., Ozawa, K., Yahagi, K., Mishima, Tsuneko, Akther, S., Vo, C. T., Lee, Ashley Bomin, Tanaka, M., Itohara, S. & Hirase, Hajime, 2021, In: Frontiers in Neural Circuits. 15, 16 p., 658343.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Twists and turns of ocular glymphatic clearance – new study reveals surprising findings in glaucoma
Rangroo Thrane, V., Hynnekleiv, L., Wang, X., Thrane, A. S., Krohn, J. & Nedergaard, Maiken, 2021, In: Acta Ophthalmologica. 99, 2, p. e283-e284 2 p.Research output: Contribution to journal › Letter › Research › peer-review
- 2022
- Published
A TCF7L2-responsive suppression of both homeostatic and compensatory remyelination in Huntington disease mice
Benraiss, A., Mariani, J. N., Tate, A., Madsen, P. M., Clark, K. M., Welle, K. A., Solly, R., Capellano, L., Bentley, K., Chandler-Militello, D. & Goldman, Steven Alan, 2022, In: Cell Reports. 40, 9, 22 p., 111291.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A molecular interactome of the glioblastoma perivascular niche reveals integrin binding sialoprotein as a mediator of tumor cell migration
Ghochani, Y., Muthukrishnan, S. D., Sohrabi, A., Kawaguchi, R., Condro, M. C., Bastola, S., Gao, F., Qin, Y., Mottahedeh, J., Iruela-Arispe, M. L., Rao, N., Laks, D. R., Liau, L. M., Mathern, G. W., Goldman, Steven Alan, Carmichael, S. T., Nakano, I., Coppola, G., Seidlits, S. K. & Kornblum, H. I., 2022, In: Cell Reports. 41, 3, 25 p., 111511.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A network model of glymphatic flow under different experimentally-motivated parametric scenarios
Tithof, J., Boster, K. A. S., Bork, Peter Aleksander Rousing, Nedergaard, Maiken, Thomas, J. H. & Kelley, D. H., 2022, In: iScience. 25, 5, 24 p., 104258.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A real-time in vivo clearance assay for quantification of glymphatic efflux
Plá, V., Bork, Peter Aleksander Rousing, Harnpramukkul, A., Olveda, G., Ladrón-de-Guevara, A., Giannetto, M. J., Hussain, R., Wang, W., Kelley, D. H., Hablitz, L. M. & Nedergaard, Maiken, 2022, In: Cell Reports. 40, 11, 20 p., 111320.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An in vivo Pig Model for Testing Novel Positron Emission Tomography Radioligands Targeting Cerebral Protein Aggregates
Raval, N. R., Nasser, A., Madsen, C. A., Beschorner, Natalie, Beaman, Emily Eufaula, Juhl, M., Lehel, S., Palner, M., Svarer, C., Plavén-Sigray, P., Jørgensen, Louise Møller & Knudsen, Gitte Moos, 2022, In: Frontiers in Neuroscience. 16, 12 p., 847074.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An fMRI-compatible system for targeted electrical stimulation
Jørgensen, Louise Møller, Baandrup, A. O., Mandeville, J., Glud, A. N., Sørensen, J. C. H., Weikop, Pia, Jespersen, B., Hansen, Adam Espe, Thomsen, C. & Knudsen, Gitte Moos, 2022, In: Journal of Neuroscience Methods. 378, 109659.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An unnoticed player overseeing CSF flux
Pla Requena, Virginia Teresa & Nedergaard, Maiken, 2022, In: Nature Cardiovascular Research. 1, 2 p.Research output: Contribution to journal › Comment/debate › Research
- Published
Antagonism of peripheral opioid receptors by methylnaltrexone does not prevent morphine tolerance in rats
Blomqvist, K. J., Dudek, K. A., Viisanen, H., Matlik, K., Ahlstrom, F. H. G., Laitila, J., Kalso, E. A., Rauhala, P. V. & Lilius, T. O., 2022, In: Journal of Neuroscience Research. 100, 1, p. 329-338 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Arterial responses to infusion of glucagon-like peptide-1 in humans: A randomized trial study
Ghanizada, Hashmat, Christensen, R. H., Al-Karagholi, M. A. M., Elbahi, F. A., Coskun, H. & dlt446, dlt446, 2022, In: Peptides. 150, 8 p., 170736.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Assessment of astrocytes as a mediator of memory and learning in rodents
Akther, S. & Hirase, Hajime, 2022, In: Glia. 70, 8, p. 1484-1505 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biophysical Modeling of Dopaminergic Denervation Landscapes in the Striatum Reveals New Therapeutic Strategy
Heltberg, Mathias Spliid, Awada, H. N., Lucchetti, Alessandra, Jensen, Mogens Høgh, Dreyer, J. K. & Rasmussen, R. N., 2022, In: eNeuro. 9, 2, 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Birthweight z-score and fat-free mass at birth predict body composition at 3 years in Danish children born from obese mothers
Berglund, N. R., Lewis, Jack Ivor, Michaelsen, Kim F., Mølgaard, Christian, Renault, Kristina Martha & Carlsen, Eva Maria Meier, 2022, In: Acta Paediatrica. 111, 7, p. 1427-1434 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Brain lipidomics and neurodevelopmental outcomes in intrauterine growth restricted piglets fed dairy or vegetable fat diets
Henriksen, Nicole Lind, Asmussen, K. S., Pan, X., Jiang, Pingping, Mori, Yuki, Christiansen, Line Iadsatian, Sprenger, R. R., Ejsing, C. S., Pankratova, Stanislava & Thymann, Thomas, 2022, In: Scientific Reports. 12, 1, 3303.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema
Du, T., Mestre, H., Kress, B. T., Liu, G., Sweeney, A. M., Samson, A. J., Rasmussen, M. K., Mortensen, K. N., Bork, P. A. R., Peng, W., Olveda, G. E., Bashford, L., Toro, E. R., Tithof, J., Kelley, D. H., Thomas, J. H., Hjorth, P. G., Martens, E. A., Mehta, R. I., Hirase, H. & 2 others, , 2022, In: Brain. 145, 2, p. 787–797 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Could dexmedetomidine be repurposed as a glymphatic enhancer?
Persson, N. D. Å., Uusalo, P., Nedergaard, Maiken, Lohela, T. J. & Lilius, T. O., 2022, In: Trends in Pharmacological Sciences. 43, 12, p. 1030-1040 11 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Depth-targeted intracortical microstroke by two-photon photothrombosis in rodent brain
Fukuda, M., Matsumura, T., Suda, T. & Hirase, Hajime, 2022, In: Neurophotonics. 9, 2, 9 p., 021910.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Developmental trajectory of episodic-like memory in rats
Asiminas, Antonios, Lyon, S. A., Langston, R. F. & Wood, E. R., 2022, In: Frontiers in Behavioral Neuroscience. 16, 20 p., 969871.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Does Long-Duration Exposure to Microgravity Lead to Dysregulation of the Brain and Ocular Glymphatic Systems?
Wostyn, P., Mader, T. H., Gibson, C. R. & Nedergaard, Maiken, 2022, In: Eye and Brain. 14, p. 49-58 10 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Dorsal striatal dopamine induces fronto-cortical hypoactivity and attenuates anxiety and compulsive behaviors in rats
Casado-Sainz, A., Gudmundsen, F., Baerentzen, S. L., Lange, D., Ringsted, A., Martinez-Tejada, I., Medina, S., Lee, H., Svarer, C., Keller, S. H., Schain, M., Kjærby, Celia, Fisher, P. M., Cumming, P. & Palner, M., 2022, In: Neuropsychopharmacology. 47, p. 454–464 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Experience-dependent changes in hippocampal spatial activity and hippocampal circuit function are disrupted in a rat model of Fragile X Syndrome
Asiminas, Antonios, Booker, S. A., Dando, O. R., Kozic, Z., Arkell, D., Inkpen, F. H., Sumera, A., Akyel, I., Kind, P. C. & Wood, E. R., 2022, In: Molecular Autism. 13, 1, 29 p., 49.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fluid Transport in the Brain
Rasmussen, Martin Kaag, Mestre, H. & Nedergaard, Maiken, 2022, In: Physiological Reviews. 102, p. 1025-1151 27 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Glymphatic system and Spaceflight Associated Neuro-Ocular Syndrome
Wostyn, P. & Nedergaard, Maiken, 2022, Spaceflight Associated Neuro-Ocular Syndrome. Elsevier, p. 67-76 10 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Human NREM Sleep Promotes Brain-Wide Vasomotor and Respiratory Pulsations
Helakari, H., Korhonen, V., Holst, S. C., Piispala, J., Kallio, M., Väyrynen, T., Huotari, N., Raitamaa, L., Tuunanen, J., Kananen, J., Järvelä, M., Tuovinen, T., Raatikainen, V., Borchardt, V., Kinnunen, H., Nedergaard, Maiken & Kiviniemi, V., 2022, In: Journal of Neuroscience. 42, 12, p. 2503-2515 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human integrin α10β1-selected mesenchymal stem cells home to cartilage defects in the rabbit knee and assume a chondrocyte-like phenotype
Andersen, Camilla, Uvebrant, K., Mori, Yuki, Aarsvold, S., Jacobsen, Stine, Berg, Lise Charlotte, Lundgren-åkerlund, E. & Lindegaard, Casper, 2022, In: Stem Cell Research & Therapy. 13, 15 p., 206.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Increased interictal synchronicity of respiratory related brain pulsations in epilepsy
Kananen, J., Järvelä, M., Korhonen, V., Tuovinen, T., Huotari, N., Raitamaa, L., Helakari, H., Väyrynen, T., Raatikainen, V., Nedergaard, Maiken, Ansakorpi, H., Jacobs, J., LeVan, P. & Kiviniemi, V., 2022, In: Journal of Cerebral Blood Flow and Metabolism. 42, 10, p. 1840-1853 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Liver-secreted fluorescent blood plasma markers enable chronic imaging of the microcirculation
Wang, Xiaowen, Delle, Christine, Asiminas, Antonios, Akther, S., Vittani, Marta, Brøgger, Peter, Kusk, P., Vo, C. T., Radovanovic, Tessa, Konno, A., Hirai, H., Fukuda, M., Weikop, Pia, Goldman, Steven Alan, Nedergaard, Maiken & Hirase, Hajime, 2022, In: Cell Reports Methods. 2, 10, 16 p., 100302.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Measurements of cerebrospinal fluid production: a review of the limitations and advantages of current methodologies
Liu, G., Ladrón-de-Guevara, A., Izhiman, Y., Nedergaard, Maiken & Du, Ting, 2022, In: Fluids and Barriers of the CNS. 19, 1, 24 p., 101.Research output: Contribution to journal › Review › Research › peer-review
- Published
Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine
Kjærby, Celia, Andersen, Mie, Hauglund, Natalie Linea, Untiet, Verena, Dall, C., Sigurdsson, B., Ding, F., Feng, J., Li, Y., Weikop, Pia, Hirase, Hajime & Nedergaard, Maiken, 2022, In: Nature Neuroscience. 25, p. 1059–1070 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Modeling the early stages of Alzheimer's disease by administering intracerebroventricular injections of human native A beta oligomers to rats
Baerends, E., Soud, K., Folke, J., Pedersen, A., Henmar, S., Konrad, Lisa, Lycas, M. D., Mori, Yuki, Pakkenberg, B., Woldbye, David Paul Drucker, Dmytriyeva, O. & Pankratova, Stanislava, 2022, In: Acta Neuropathologica Communications. 10, 1, 21 p., 113.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
More than meets the eye: The metabolic state of the body shapes visual sensations
Carlsen, Eva Maria Meier & Rasmussen, R. N., 2022, In: Cell Metabolism. 34, 1, p. 9-10 2 p.Research output: Contribution to journal › Editorial › Research › peer-review
- Published
Periarteriolar spaces modulate cerebrospinal fluid transport into brain and demonstrate altered morphology in aging and Alzheimer’s disease
Mestre, H., Verma, N., Greene, T. D., Lin, L. J. A., Ladron-de-Guevara, A., Sweeney, A. M., Liu, G., Thomas, V. K., Galloway, C. A., de Mesy Bentley, K. L., Nedergaard, Maiken & Mehta, R. I., 2022, In: Nature Communications. 13, 1, 8 p., 3897.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Perivascular pumping in the mouse brain: Improved boundary conditions reconcile theory, simulation, and experiment
Ladrón-de-Guevara, A., Shang, J. K., Nedergaard, Maiken & Kelley, D. H., 2022, In: Journal of Theoretical Biology. 542, 111103.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Physiological Mechanisms and Significance of Intracranial B Waves
Newell, D. W., Nedergaard, Maiken & Aaslid, R., 2022, In: Frontiers in Neurology. 13, 13 p., 872701.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Posthemorrhagic hydrocephalus associates with elevated inflammation and CSF hypersecretion via activation of choroidal transporters
Lolansen, Sara Diana, Rostgaard, Nina, Barbuskaite, Dagne, Capion, T., Olsen, M. H., Norager, N. H., Vilhardt, Frederik, Andreassen, Søren Norge, Toft-Bertelsen, Trine Lisberg, Ye, F., Juhler, Marianne, Keep, R. F. & MacAulay, Nanna, 2022, In: Fluids and Barriers of the CNS. 19, 1, 19 p., 62.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pretargeted Imaging beyond the Blood–Brain Barrier: Utopia or Feasible?
Lopes van den Broek, S., Shalgunov, Vladimir, García Vázquez, R., Beschorner, Natalie, Bidesi, N. S. R., Nedergaard, Maiken, Knudsen, Gitte Moos, Sehlin, D., Syvänen, S. & Herth, Matthias Manfred, 2022, In: Pharmaceuticals. 15, 10, 13 p., 1191.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Psilocybin-induced reduction in chronic cluster headache attack frequency correlates with changes in hypothalamic functional connectivity
Madsen, M. K., Petersen, A. S., Stenbæk, Dea Siggaard, Sorensen, I. M., Schionning, H., Fjeld, T., Nykjaer, C., Larsen, S. M. U., Grzywacz, M., Mathiesen, T., Klausen, I., Hansen, O. O., Brendstrup-Brix, K., Linnet, Kristian, Johansen, Sys Stybe, Fisher, P. M., Jensen, Rasmus Herlo Beenfeldt, Knudsen, Gitte Moos & Madsen, M. K., 2022, medRxiv, 17 p.Research output: Working paper › Preprint › Research
- Published
SPECT/CT imaging reveals CNS-wide modulation of glymphatic cerebrospinal fluid flow by systemic hypertonic saline
Lilius, T. O., Rosenholm, Marko, Klinger, L., Mortensen, K. N., Sigurdsson, B., Mogensen, F. L., Hauglund, Natalie Linea, Nielsen, Malthe Skytte Nordentoft, Rantamaki, T. & Nedergaard, Maiken, 2022, In: iScience. 25, 10, 17 p., 105250.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
SpAD Biofunctionalized Cellulose Acetate Scaffolds Inhibit Staphylococcus aureus Adherence in a Coordinating Function with the von Willebrand A1 Domain (vWF A1)
Pendas, S., Asiminas, Antonios, Katranidis, A., Tsioptsias, C., Pitou, M., Papadopoulos, G. & Choli-Papadopoulou, T., 2022, In: Journal of Functional Biomaterials. 13, 17 p., 21.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Systemic hypertonic saline enhances glymphatic spinal cord delivery of lumbar intrathecal morphine
Blomqvist, K. J., Skogster, M. O. B., Kurkela, M. J., Rosenholm, Marko, Ahlström, F. H. G., Airavaara, M. T., Backman, J. T., Rauhala, P. V., Kalso, E. A. & Lilius, T. O., 2022, In: Journal of Controlled Release. 344, p. 214-224 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
TUBE project: Transport-derived ultrafines and the brain effects
Martikainen, M. V., Aakko-Saksa, P., Broek, L. V. D., Cassee, F. R., Carare, R. O., Chew, S., Dinnyes, A., Giugno, R., Kanninen, K. M., Malm, T., Muala, A., Nedergaard, M., Oudin, A., Oyola, P., Pfeiffer, T. V., Rönkkö, T., Saarikoski, S., Sandström, T., Schins, R. P. F., Topinka, J. & 4 others, , 2022, In: International Journal of Environmental Research and Public Health. 19, 1, 14 p., 311.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Acute and Chronic Effects of Acetazolamide and Topiramate on Intracranial Pressure and CSF Secretion
Westgate, C., Kamp-Jensen, C., Israelsen, I., Toft-Bertelsen, Trine Lisberg, Wardman, Jonathan Henry, Jensen, C., Styrishave, Bjarne, MacAulay, Nanna, Jensen, Rasmus Herlo Beenfeldt & Eftekhari, S., 2022, In: Journal of Headache and Pain. 23, Suppl. 1, 1 p., P218.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
The Effect of Hyperoxia on Central and Peripheral Factors of Arm Flexor Muscles Fatigue Following Maximal Ergometer Rowing in Men
Volianitis, S., Rasmussen, P., Petersen, Nicolas Caesar & Secher, Niels H., 2022, In: Frontiers in Physiology. 13, 10 p., 829097.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The association of anxiety and other clinical features with CACNA1C rs1006737 in patients with depression
Dam, H., Buch, J. O. D., Nielsen, A. B., Weikop, Pia & Jørgensen, Martin Balslev, 2022, In: Translational Neuroscience. 13, 1, p. 320-326 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effect of long-duration spaceflight on perivascular spaces within the brain
Wostyn, P., Mader, T. H., Gibson, C. R. & Nedergaard, Maiken, 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 32, 1 p., e2207724119.Research output: Contribution to journal › Letter › Research › peer-review
- Published
The elusive varicose astrocytes
Rasmussen, R. N. & Smith, N. A., 2022, In: Trends in Neurosciences. 45, 2, p. 94-95 2 p.Research output: Contribution to journal › Comment/debate › Research
- Published
The glymphatic system: implications for drugs for central nervous system diseases
Lohela, T. J., Lilius, T. O. & Nedergaard, Maiken, 2022, In: Nature Reviews Drug Discovery. 21, 10, p. 763-779 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The glymphatic system: Current understanding and modeling
Bohr, T., Hjorth, P. G., Holst, S. C., Hrabětová, S., Kiviniemi, V., Lilius, T., Lundgaard, I., Mardal, K. A., Martens, E. A., Mori, Yuki, Nägerl, U. V., Nicholson, C., Tannenbaum, A., Thomas, J. H., Tithof, J., Benveniste, H., Iliff, J. J., Kelley, D. H. & Nedergaard, Maiken, 2022, In: iScience. 25, 9, 33 p., 104987.Research output: Contribution to journal › Review › Research › peer-review
- Published
The role of central serotonergic markers and estradiol changes in perinatal mental health
Borgsted, C., Høgh, S., Høgsted, E. S., Fonnesbech-Sandberg, L., Ekelund, Kim, Albrechtsen, C. K., Wiis, J. T., Hegaard, Hanne Kristine, Cvetanovska, E., Juul, Anders, Frederiksen, H., Pinborg, Anja, Weikop, Pia & Frøkjær, Vibe Gedsø, 2022, In: Acta Psychiatrica Scandinavica. 146, 4, p. 357-369 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Translating cell therapies for neurodegenerative diseases: Huntington's disease as a model disorder
Rosser, A. E., Busse, M. E., Gray, W. P., Badin, R. A., Perrier, A. L., Wheelock, V., Cozzi, E., Martin, U. P., Salado-Manzano, C., Mills, L. J., Drew, C., Goldman, Steven Alan, Canals, J. M., Thompson, L. M. & SC4HD Members, S. M., 2022, In: Brain. 145, 5, p. 1584-1597 14 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Validation of ultrasonography for measurement of cartilage thickness in the equine carpus
Andersen, Camilla, Griffin, J. F., Jacobsen, Stine, Østergaard, Stine, Walters, M., Mori, Yuki & Lindegaard, Casper, 2022, In: Veterinary Radiology & Ultrasound. 63, 4, p. 478-489 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Versatile treadmill system for measuring locomotion and neural activity in head-fixed mice
Carlsen, Eva Maria Meier, Nedergaard, Maiken & Rasmussen, R. N., 2022, In: STAR Protocols. 3, 4, 14 p., 101701.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Using crystallography tools to improve vaccine formulations
de Abreu Fantini, M. C., Pinto Oliveira, C. L., de Souza Lopes, J. L., Martins, T. D. S., Akamatsu, M. A., Trezena, A. G., Tino-De-Franco, M., Botosso, V. F., Brazil Esteves Sant'Anna, O. A., Kardjilov, N., Rasmussen, Martin Kaag & Nunes Bordallo, Heloisa, 1 Jan 2022, In: IUCrJ. 9, p. 11-20 14 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Single cell mapping the evolution of the spatial processing centre within the brain
Ralbovszki, Dorottya Maria, Bertelsen, Mads Frost, Buchmann, Kurt, Mori, Yuki, Gorodkin, Jan, Hemberg, M., Seemann, Ernst Stefan, Khodosevich, Konstantin & Hall, Vanessa Jane, 1 May 2022.Research output: Contribution to conference › Poster › Communication
- 2023
- Published
A SPECT-based method for dynamic imaging of the glymphatic system in rats
Sigurdsson, B., Hauglund, Natalie Linea, Lilius, T. O., Mogensen, F. L. H., Mortensen, K. N., Beschorner, Natalie, Klinger, L., Bærentzen, S. L., Rosenholm, Marko, Shalgunov, Vladimir, Herth, Matthias Manfred, Mori, Yuki & Nedergaard, Maiken, 2023, In: Journal of Cerebral Blood Flow and Metabolism. 43, 7, 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A mesothelium divides the subarachnoid space into functional compartments
Møllgård, Kjeld, Beinlich, Felix Ralf Michael, Kusk, P., Miyakoshi, L. M., Delle, Christine, Pla Requena, Virginia Teresa, Hauglund, Natalie Linea, Esmail, Tina, Rasmussen, Martin Kaag, Gomolka, Ryszard Stefan, Mori, Yuki & Nedergaard, Maiken, 2023, In: Science. 379, 6627, p. 84-885Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A sensitive and specific genetically-encoded potassium ion biosensor for in vivo applications across the tree of life
Wu, S-Y., Wen, Y., Serre, N. B. C., Laursen, C. C. H., Dietz, A. G., Taylor, B. R., Drobizhev, M., Molina, R. S., Aggarwal, A., Rancic, V., Becker, M., Ballanyi, K., Podgorski, K., Hirase, H., Nedergaard, M., Fendrych, M., Lemieux, M. J., Eberl, D. F., Kay, A. R., Campbell, R. E. & 1 others, , 2023, In: PLOS Biology. 20, 9, 23 p., e3001772.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Age- and glaucoma-induced changes to the ocular glymphatic system
Wang, X., Delle, Christine, Peng, W., Pla Requena, Virginia Teresa, Giannetto, M., Kusk, P., Sigurdsson, B., Sakurai, S., Sweeney, A., Sun, Q., Du, Ting, Libby, R. T. & Nedergaard, Maiken, 2023, In: Neurobiology of Disease. 188, 9 p., 106322.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Air pollution, glymphatic impairment, and Alzheimer's disease
Hussain, R., Graham, U., Elder, A. & Nedergaard, Maiken, 2023, In: Trends in Neurosciences. 46, 11, p. 901-911 11 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Astrocyte endfeet may theoretically act as valves to convert pressure oscillations to glymphatic flow
Bork, Peter Aleksander Rousing, Ladrón-De-Guevara, A., Christensen, A. H., Jensen, K. H., Nedergaard, Maiken & Bohr, T., 2023, In: Journal of the Royal Society Interface. 20, 204, 5 p., 20230050.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Astrocytes: integrators of arousal state and sensory context
Rasmussen, R. N., Asiminas, Antonios, Carlsen, Eva Maria Meier, Kjærby, Celia & Smith, N. A., 2023, In: Trends in Neurosciences. 46, 6, 8 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Astrocytes as master modulators of neural networks: Synaptic functions and disease-associated dysfunction of astrocytes
Stogsdill, J. A., Harwell, C. C. & Goldman, Steven Alan, 2023, In: Annals of the New York Academy of Sciences. 1525, 1, p. 41-60 20 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Astrocytic GPCR-Induced Ca2+ Signaling Is Not Causally Related to Local Cerebral Blood Flow Changes
Ozawa, K., Nagao, Masaki, Konno, A., Iwai, Y., Vittani, Marta, Kusk, P., Mishima, Tsuneko, Hirai, H., Nedergaard, Maiken & Hirase, Hajime, 2023, In: International Journal of Molecular Sciences. 24, 17, 12 p., 13590.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Astrocytic chloride is brain state dependent and modulates inhibitory neurotransmission in mice
Untiet, Verena, Beinlich, Felix Ralf Michael, Kusk, P., Kang, N., Ladrón-de-Guevara, A., Song, W., Kjærby, Celia, Andersen, Mie, Hauglund, Natalie Linea, Bojarowska, Zuzanna, Sigurdsson, B., Deng, S., Hirase, Hajime, Petersen, Nicolas Caesar, Verkhratsky, A. & Nedergaard, Maiken, 2023, In: Nature Communications. 14, 1, 14 p., 1871.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Astrocytic contributions to Huntington's disease pathophysiology
Khakh, B. S. & Goldman, Steven Alan, 2023, In: Annals of the New York Academy of Sciences. 1522, 1, p. 42-59 18 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Astrocytic engagement of the corticostriatal synaptic cleft is disrupted in a mouse model of Huntington’s disease
Villanueva, C. B., Stephensen, Hans Jacob Teglbjærg, Mokso, R., Benraiss, A., Sporring, Jon & Goldman, Steven Alan, 2023, In: Proceedings of the National Academy of Sciences USA (PNAS). 120, 24, 11 p., e2210719120.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Behavioral and biochemical effects of alcohol withdrawal in female C3H/HeNRj and C57BL/6JRj mice
Tonetto, S., Weikop, Pia, Brudek, T. & Thomsen, M., 2023, In: Frontiers in Behavioral Neuroscience. 17, 18 p., 1143720.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Blood–brain barrier permeable β-blockers linked to lower risk of Alzheimer’s disease in hypertension
Beaman, Emily Eufaula, Bonde, A. N., Larsen, S. M. U., Ozenne, Brice Maxime Hugues, Lohela, T. J., Nedergaard, Maiken, Gislason, Gunnar Hilmar, Knudsen, Gitte Moos & Holst, S. C., 2023, In: Brain. 146, 3, p. 1141–1151 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Brain-specific glycosylation of protein tyrosine phosphatase receptor type Z (PTPRZ) marks a demyelination-associated astrocyte subtype
Takahashi, K., Kanekiyo, K., Sakuda, K., Muto, Y., Iguchi, M., Matsuda, N., Hashimoto, Y., Kanai, K., Ogawa, H., Hirase, Hajime, Kakita, A., Bizen, N., Takebayashi, H., Kawaguchi, Y., Uzuki, M. & Kitazume, S., 2023, In: Journal of Neurochemistry. 166, 3, 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Delivery of gene therapy through a cerebrospinal fluid conduit to rescue hearing in adult mice
Mathiesen, B. K., Miyakoshi, L. M., Cederroth, C. R., Tserga, E., Versteegh, C., Bork, Peter Aleksander Rousing, Hauglund, Natalie Linea, Gomolka, Ryszard Stefan, Mori, Yuki, Edvall, N. K., Rouse, S., Møllgård, Kjeld, Holt, J. R., Nedergaard, Maiken & Canlon, B., 2023, In: Science Translational Medicine. 15, 702, 13 p., eabq3916.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development of 11C-labeled CRANAD-102 for positron emission tomography imaging of soluble Aβ-species
Staudt, Markus, Shalgunov, Vladimir, Nedergaard, Maiken & Herth, Matthias Manfred, 2023, In: Journal of Labelled Compounds and Radiopharmaceuticals. 66, 12, p. 393-399Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Early impairments of visually-driven neuronal ensemble dynamics in the rTg4510 tauopathy mouse model
Parka, A., Degel, C., Dreyer, J., Richter, U., Hall, B., Bastlund, J. F., Laursen, B., Nedergaard, Maiken, Sotty, F. & Botta, P., 2023, In: Neurobiology of Disease. 178, 13 p., 106012.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of sleep deprivation and NREM sleep stage on physiological brain pulsations
Helakari, H., Järvelä, M., Väyrynen, T., Tuunanen, J., Piispala, J., Kallio, M., Ebrahimi, S. M., Poltojainen, V., Kananen, J., Elabasy, A., Huotari, N., Raitamaa, L., Tuovinen, T., Korhonen, V., Nedergaard, Maiken & Kiviniemi, V., 2023, In: Frontiers in Neuroscience. 17, 17 p., 1275184.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glial progenitor cells of the adult human white and grey matter are contextually distinct
Osorio, M. J., Mariani, J. N., Zou, L., Schanz, S. J., Heffernan, K., Cornwell, A. & Goldman, Steven Alan, 2023, In: Glia. 71, 3, p. 524-540 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glymphatic influx and clearance are accelerated by neurovascular coupling: [Inkl. Correction]
Holstein-Rønsbo, Stephanie, Gan, Y., Giannetto, M. J., Rasmussen, Martin Kaag, Sigurdsson, B., Beinlich, Felix Ralf Michael, Rose, Laura, Untiet, Verena, Hablitz, L. M., Kelley, D. H. & Nedergaard, Maiken, 2023, In: Nature Neuroscience. 26, p. 1042–1053Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glymphatic-assisted perivascular brain delivery of intrathecal small gold nanoparticles
Lilius, T. O., Mortensen, K. N., Deville, C., Lohela, T. J., Stæger, Frederik Filip Vinggaard, Sigurdsson, B., Fiordaliso, E. M., Rosenholm, Marko, Kamphuis, C., Beekman, F. J., Jensen, A. I. & Nedergaard, Maiken, 2023, In: Journal of Controlled Release. 355, p. 135-148 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Insulin-like growth factor 1 supplementation supports motor coordination and affects myelination in preterm pigs
Christiansen, Line Iadsatian, Ventura, G. C., Holmqvist, B., Aasmul-Olsen, Karoline, Lindholm, S. E. H., Lycas, M. D., Mori, Yuki, Secher, Jan Bojsen-Møller, Burrin, D. G., Thymann, Thomas, Sangild, Per Torp & Pankratova, Stanislava, 2023, In: Frontiers in Neuroscience. 17, 15 p., 1205819.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ketamine reduces electrophysiological network activity in cortical neuron cultures already at sub-micromolar concentrations – Impact on TrkB-ERK1/2 signaling
Ahtiainen, A., Annala, I., Rosenholm, Marko, Kohtala, S., Hyttinen, J., Tanskanen, J. M. A. & Rantamäki, T., 2023, In: Neuropharmacology. 229, 11 p., 109481.Research output: Contribution to journal › Review › Research › peer-review
- Published
Lactate biosensors for spectrally and spatially multiplexed fluorescence imaging
Nasu, Y., Aggarwal, A., Le, G. N. T., Vo, C. T., Kambe, Y., Wang, X., Beinlich, F. R. M., Lee, A. B., Ram, T. R., Wang, F., Gorzo, K. A., Kamijo, Y., Boisvert, M., Nishinami, S., Kawamura, G., Ozawa, T., Toda, H., Gordon, G. R., Ge, S., Hirase, H. & 5 others, , 2023, In: Nature Communications. 14, 1, 17 p., 6598.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Local extracellular K+ in cortex regulates norepinephrine levels, network state, and behavioral output
Dietz, Andrea Grostøl, Weikop, Pia, Hauglund, Natalie Linea, Andersen, Mie, Petersen, Nicolas Caesar, Rose, Laura, Hirase, Hajime & Nedergaard, Maiken, 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 40, 9 p., e2305071120.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Locomotion Induces Fundamentally Different Patterns of Ca2+Signaling in Astrocytes and Neurons
Hirase, Hajime & Nedergaard, Maiken, 2023, In: Function. 4, 4, 2 p., zqad028.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Long-term high-fat diet increases glymphatic activity in the hypothalamus in mice
Delle, Christine, Cankar, Neza, Digebjerg Holgersson, C., Hvorup Knudsen, H., Nielsen, Elise Schiøler, Kjærby, Celia, Mori, Yuki, Nedergaard, Maiken & Weikop, Pia, 2023, In: Scientific Reports. 13, 1, 11 p., 4137.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation
Gomolka, Ryszard Stefan, Hablitz, L. M., Mestre, H., Giannetto, M., Du, Ting, Hauglund, Natalie Linea, Xie, L., Peng, W., Martinez, P. M., Nedergaard, Maiken & Mori, Yuki, 2023, In: eLife. 12, 36 p., e82232.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Perivascular pumping of cerebrospinal fluid in the brain with a valve mechanism
Gan, Y., Holstein-Rønsbo, Stephanie, Nedergaard, Maiken, Boster, K. A. S., Thomas, J. H. & Kelley, D. H., 2023, In: Journal of the Royal Society, Interface. 20, 206, 17 p., 20230288.Research output: Contribution to journal › Journal article › Research › peer-review
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SPECT imaging of the glymphatic pathway with In-111-labeled ovalbumin in the rat brain
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In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy
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Understanding the functions and relationships of the glymphatic system and meningeal lymphatics
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Remyelination in the Central Nervous System
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Glymphatic fluid transport is suppressed by the aquaporin-4 inhibitor AER-271
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The glymphatic system and Amyotrophic lateral sclerosis
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