Transient Astrocytic Gq Signaling Underlies Remote Memory Enhancement
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- Transient Astrocytic Gq Signaling Underlies Remote Memory Enhancement
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Astrocytes elicit transient Ca2+ elevations induced by G protein-coupled receptors (GPCRs), yet their role in vivo remains unknown. To address this, transgenic mice with astrocytic expression of the optogenetic Gq-type GPCR, Optoα1AR, were established, in which transient Ca2+ elevations similar to those in wild type mice were induced by brief blue light illumination. Activation of cortical astrocytes resulted in an adenosine A1 receptor-dependent inhibition of neuronal activity. Moreover, sensory stimulation with astrocytic activation induced long-term depression of sensory evoked response. At the behavioral level, repeated astrocytic activation in the anterior cortex gradually affected novel open field exploratory behavior, and remote memory was enhanced in a novel object recognition task. These effects were blocked by A1 receptor antagonism. Together, we demonstrate that GPCR-triggered Ca2+ elevation in cortical astrocytes has causal impacts on neuronal activity and behavior.
Original language | English |
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Article number | 658343 |
Journal | Frontiers in Neural Circuits |
Volume | 15 |
Number of pages | 16 |
ISSN | 1662-5110 |
DOIs | |
Publication status | Published - 2021 |
- astrocytes, Ca signaling, G protein-coupled receptor, memory, OptoA1AR, optogenetic activation
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