Center for Translational Neuromedicine focuses on developing new approaches for investigating and treating neurological diseases, primarily using the tools of physiology and imaging coupled with cell and gene therapy. Our emphasis is on using these technologies to enable neural and glial cell replacement in the adult brain and spinal cord, as a means of both disease modeling and therapeutic repair. The principal groups in the Center include Dr. Goldman’s lab Division of Cell and Gene Therapy that focuses on neural stem cell and glial progenitor biology and the translational applications thereof; Dr. Nedergaard’s lab Division of Glial Disease and Therapeutics that focuses on astrocytic physiology and pathology, as well as on cerebral blood flow and its glial regulation; and Dr. Hirase’s lab Division of Neuron-Glia Circuitry that focuses on in vivo neuron–astrocyte interactions and plasticity. Together, the labs are expanding the scope of glial biology, such that disorders long thought neuronal in nature are now being investigated as disorders principally of glial cells, including both astrocytes and oligodendrocytes as well as their progenitors.