Center for Translational Neuromedicine

  1. 2022
  2. Published

    A real-time in vivo clearance assay for quantification of glymphatic efflux

    Plá, V., Bork, Peter Aleksander Rousing, Harnpramukkul, A., Olveda, G., Ladrón-de-Guevara, A., Giannetto, M. J., Hussain, R., Wang, W., Kelley, D. H., Hablitz, L. M. & Nedergaard, Maiken, 2022, In: Cell Reports. 40, 11, 20 p., 111320.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    An unnoticed player overseeing CSF flux

    Pla Requena, Virginia Teresa & Nedergaard, Maiken, 2022, In: Nature Cardiovascular Research. 1, 2 p.

    Research output: Contribution to journalComment/debateResearch

  4. Published
  5. Published

    Fluid Transport in the Brain

    Rasmussen, Martin Kaag, Mestre, H. & Nedergaard, Maiken, 2022, In: Physiological Reviews. 102, p. 1025-1151 27 p.

    Research output: Contribution to journalReviewResearchpeer-review

  6. Published

    The elusive varicose astrocytes

    Rasmussen, R. N. & Smith, N. A., 2022, In: Trends in Neurosciences. 45, 2, p. 94-95 2 p.

    Research output: Contribution to journalComment/debateResearch

  7. Published

    An in vivo Pig Model for Testing Novel Positron Emission Tomography Radioligands Targeting Cerebral Protein Aggregates

    Raval, N. R., Nasser, A., Madsen, C. A., Beschorner, Natalie, Beaman, Emily Eufaula, Juhl, M., Lehel, S., Palner, M., Svarer, C., Plavén-Sigray, P., Jørgensen, Louise Møller & Knudsen, Gitte Moos, 2022, In: Frontiers in Neuroscience. 16, 12 p., 847074.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Translating cell therapies for neurodegenerative diseases: Huntington's disease as a model disorder

    Rosser, A. E., Busse, M. E., Gray, W. P., Badin, R. A., Perrier, A. L., Wheelock, V., Cozzi, E., Martin, U. P., Salado-Manzano, C., Mills, L. J., Drew, C., Goldman, Steven Alan, Canals, J. M., Thompson, L. M. & SC4HD Members, S. M., 2022, In: Brain. 145, 5, p. 1584-1597 14 p.

    Research output: Contribution to journalReviewResearchpeer-review

  9. Published

    A network model of glymphatic flow under different experimentally-motivated parametric scenarios

    Tithof, J., Boster, K. A. S., Bork, Peter Aleksander Rousing, Nedergaard, Maiken, Thomas, J. H. & Kelley, D. H., 2022, In: iScience. 25, 5, 24 p., 104258.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    The Effect of Hyperoxia on Central and Peripheral Factors of Arm Flexor Muscles Fatigue Following Maximal Ergometer Rowing in Men

    Volianitis, S., Rasmussen, P., Petersen, Nicolas Caesar & Secher, Niels H., 2022, In: Frontiers in Physiology. 13, 10 p., 829097.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Liver-secreted fluorescent blood plasma markers enable chronic imaging of the microcirculation

    Wang, Xiaowen, Delle, Christine, Asiminas, Antonios, Akther, S., Vittani, Marta, Brøgger, Peter, Kusk, P., Vo, C. T., Radovanovic, Tessa, Konno, A., Hirai, H., Fukuda, M., Weikop, Pia, Goldman, Steven Alan, Nedergaard, Maiken & Hirase, Hajime, 2022, In: Cell Reports Methods. 2, 10, 16 p., 100302.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    The Acute and Chronic Effects of Acetazolamide and Topiramate on Intracranial Pressure and CSF Secretion

    Westgate, C., Kamp-Jensen, C., Israelsen, I., Toft-Bertelsen, Trine Lisberg, Wardman, Jonathan Henry, Jensen, C., Styrishave, Bjarne, MacAulay, Nanna, Jensen, Rasmus Herlo Beenfeldt & Eftekhari, S., 2022, In: Journal of Headache and Pain. 23, Suppl. 1, 1 p., P218.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  13. Published

    Does Long-Duration Exposure to Microgravity Lead to Dysregulation of the Brain and Ocular Glymphatic Systems?

    Wostyn, P., Mader, T. H., Gibson, C. R. & Nedergaard, Maiken, 2022, In: Eye and Brain. 14, p. 49-58 10 p.

    Research output: Contribution to journalReviewResearchpeer-review

  14. Published

    Glymphatic system and Spaceflight Associated Neuro-Ocular Syndrome

    Wostyn, P. & Nedergaard, Maiken, 2022, Spaceflight Associated Neuro-Ocular Syndrome. Elsevier, p. 67-76 10 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  15. Published

    The effect of long-duration spaceflight on perivascular spaces within the brain

    Wostyn, P., Mader, T. H., Gibson, C. R. & Nedergaard, Maiken, 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 32, 1 p., e2207724119.

    Research output: Contribution to journalLetterResearchpeer-review

  16. Published

    Using crystallography tools to improve vaccine formulations

    de Abreu Fantini, M. C., Pinto Oliveira, C. L., de Souza Lopes, J. L., Martins, T. D. S., Akamatsu, M. A., Trezena, A. G., Tino-De-Franco, M., Botosso, V. F., Brazil Esteves Sant'Anna, O. A., Kardjilov, N., Rasmussen, Martin Kaag & Nunes Bordallo, Heloisa, 1 Jan 2022, In: IUCrJ. 9, p. 11-20 14 p.

    Research output: Contribution to journalReviewResearchpeer-review

  17. 2021
  18. Published

    Spared Nerve Injury Causes Sexually Dimorphic Mechanical Allodynia and Differential Gene Expression in Spinal Cords and Dorsal Root Ganglia in Rats

    Ahlstrom, F. H. G., Matlik, K., Viisanen, H., Blomqvist, K. J., Liu, X., Lilius, T. O., Sidorova, Y., Kalso, E. A. & Rauhala, P. V., 2021, In: Molecular Neurobiology. 58, p. 5396–5419 24 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Not All Lectins Are Equally Suitable for Labeling Rodent Vasculature

    Battistella, R., Kritsilis, M., Matuskova, H., Haswell, D., Cheng, A. X., Meissner, A., Nedergaard, Maiken & Lundgaard, I., 2021, In: International Journal of Molecular Sciences (Online). 22, 21, 11554.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Cell-intrinsic glial pathology is conserved across human and murine models of Huntington's disease

    Benraiss, A., Mariani, J. N., Osipovitch, M., Cornwell, A., Windrem, M. S., Villanueva, C. B., Chandler-Militello, D. & Goldman, Steven Alan, 2021, In: Cell Reports. 36, 1, 25 p., 109308.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Cerebral small vessel disease: A glymphopathy?

    Benveniste, H. & Nedergaard, Maiken, 2021, In: Current Opinion in Neurobiology. 72, p. 15-21 7 p.

    Research output: Contribution to journalReviewResearchpeer-review

  22. Published

    Inverse correlation of fluctuations of cerebral blood and water concentrations in humans

    Borchardt, V., Korhonen, V., Helakari, H., Nedergaard, Maiken, Myllylä, T. & Kiviniemi, V., 2021, In: European Physical Journal Plus. 136, 5, 497.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Probing the polarity of spontaneous perisomatic GABAergic synaptic transmission in the mouse CA3 circuit in vivo

    Dubanet, O., Da Silva, A. F. G., Frick, A., Hirase, Hajime, Beyeler, A. & Leinekugel, X., 2021, In: Cell Reports. 36, 2, 19 p., 109381.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    RIF1 and KAP1 differentially regulate the choice of inactive versus active X chromosomes

    Enervald, E., Powell, L. M., Boteva, L., Foti, R., Blanes Ruiz, N., Kibar, G., Piszczek, A., Cavaleri, F., Vingron, M., Cerase, A. & Buonomo, S. B. C., 2021, In: EMBO Journal. 40, 22, 16 p., e105862 .

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Reactive astrocyte nomenclature, definitions, and future directions

    Escartin, C., Galea, E., Lakatos, A., O'Callaghan, J. P., Petzold, G. C., Serrano-Pozo, A., Steinhauser, C., Volterra, A., Carmignoto, G., Agarwal, A., Allen, N. J., Araque, A., Barbeito, L., Barzilai, A., Bergles, D. E., Bonvento, G., Butt, A. M., Chen, W-T., Cohen-Salmon, M., Cunningham, C. & 61 others, Deneen, B., De Strooper, B., Diaz-Castro, B., Farina, C., Freeman, M., Gallo, V., Goldman, J. E., Goldman, Steven Alan, Gotz, M., Gutierrez, A., Haydon, P. G., Heiland, D. H., Hol, E. M., Holt, M. G., Iino, M., Kastanenka, K. V., Kettenmann, H., Khakh, B. S., Koizumi, S., Lee, C. J., Liddelow, S. A., MacVicar, B. A., Magistretti, P., Messing, A., Mishra, A., Molofsky, A. V., Murai, K. K., Norris, C. M., Okada, S., Oliet, S. H. R., Oliveira, J. F., Panatier, A., Parpura, V., Pekna, M., Pekny, M., Pellerin, L., Perea, G., Perez-Nievas, B. G., Pfrieger, F. W., Poskanzer, K. E., Quintana, F. J., Ransohoff, R. M., Riquelme-Perez, M., Robel, S., Rose, C. R., Rothstein, J. D., Rouach, N., Rowitch, D. H., Semyanov, A., Sirko, S., Sontheimer, H., Swanson, R. A., Vitorica, J., Wanner, I., Wood, L. B., Wu, J., Zheng, B., Zimmer, E. R., Zorec, R., Sofroniew, M. V. & Verkhratsky, A., 2021, In: Nature Neuroscience. 24, p. 312–325 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Glial progenitor cell-based repair of the dysmyelinated brain: Progression to the clinic

    Goldman, Steven Alan, Mariani, J. N. & Madsen, P. M., 2021, In: Seminars in Cell and Developmental Biology. 116, p. 62-70 9 p.

    Research output: Contribution to journalReviewResearchpeer-review

  27. Published

    CSF space volumetry using 3D-CISS in Aqp4-deficient mice – quantitative analysis and technical advances

    Gomolka, Ryszard Stefan, Nedergaard, Maiken & Mori, Yuki, 2021, Book of Abstracts ESMRMB 2021 Online 38th Annual Scientific Meeting 7-9 October 2021. Springer, Vol. 34. p. S95-6 2 p. (Magnetic Resonance Materials in Physics, Biology, and Medicine; No. 34).

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

  28. Published

    The glymphatic system: A novel component of fundamental neurobiology

    Hablitz, L. M. & Nedergaard, Maiken, 2021, In: Journal of Neuroscience. 41, 37, p. 7698-7711 14 p.

    Research output: Contribution to journalReviewResearchpeer-review

  29. Published

    The continued need for animals to advance brain research

    Homberg, J. R., Adan, R. A. H., Alenina, N., Asiminas, A., Bader, M., Beckers, T., Begg, D. P., Blokland, A., Burger, M. E., van Dijk, G., Eisel, U. L. M., Elgersma, Y., Englitz, B., Fernandez-Ruiz, A., Fitzsimons, C. P., van Dam, A-M., Gass, P., Grandjean, J., Havekes, R., Henckens, M. J. A. G. & 54 others, Herden, C., Hut, R. A., Jarrett, W., Jeffrey, K., Jezova, D., Kalsbeek, A., Kamermans, M., Kas, M. J., Kasri, N. N., Kiliaan, A. J., Kolk, S. M., Korosi, A., Korte, S. M., Kozicz, T., Kushner, S. A., Leech, K., Leech, K., Lesscher, H., Lucassen, P. J., Luthi, A., Ma, L., Mallien, A. S., Meerlo, P., Mejias, J. F., Meye, F. J., Mitchell, A. S., Mul, J. D., Olcese, U., Gonzalez, A. O., Oliver, J. D. A., Pasqualetti, M., Pennartz, C. A., Popik, P., Prickaerts, J., de la Prida, L. M., Ribeiro, S., Roozendaal, B., Rossato, J. I., Salari, A., Schoemaker, R. G., Smit, A. B., Takeuchi, T., van der Veen, R., Smidt, M. P., V. Vyazovskiy, V., Wiesmann, M., Wierenga, C. J., Williams, B., Willuhn, I., Woehr, M., Wolvekamp, M., van der Zee, E. A., Genzel, L. & Vanderschuren, L. J. M. J., 2021, In: Neuron. 109, 15, p. 2374-2379 6 p.

    Research output: Contribution to journalEditorialResearchpeer-review

  30. Published

    ISSCR guidelines for the transfer of human pluripotent stem cells and their direct derivatives into animal hosts

    Hyun, I., Clayton, E. W., Cong, Y., Fujita, M., Goldman, Steven Alan, Hill, L. R., Monserrat, N., Nakauchi, H., Pedersen, R. A., Rooke, H. M., Takahashi, J. & Knoblich, J. A., 2021, In: Stem Cell Reports. 16, 6, p. 1409-1415 7 p.

    Research output: Contribution to journalReviewResearchpeer-review

  31. Published

    Transient Astrocytic Gq Signaling Underlies Remote Memory Enhancement

    Iwai, Y., Ozawa, K., Yahagi, K., Mishima, Tsuneko, Akther, S., Vo, C. T., Lee, Ashley Bomin, Tanaka, M., Itohara, S. & Hirase, Hajime, 2021, In: Frontiers in Neural Circuits. 15, 16 p., 658343.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Donor cell memory confers a metastable state of directly converted cells

    Kim, K. P., Li, C., Bunina, D., Jeong, H. W., Ghelman, J., Yoon, J., Shin, B., Park, H., Han, D. W., Zaugg, J. B., Kim, J., Kuhlmann, T., Adams, R. H., Noh, K. M., Goldman, Steven Alan & Schöler, H. R., 2021, In: Cell Stem Cell. 28, 7, p. 1291-1306.e10 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Introducing the special issue on “Proteins and Circuits in Memory”

    Kjærgaard, M., Petersen, Nicolas Caesar, Sørensen, Jakob Balslev & Takeuchi, T., 2021, In: European Journal of Neuroscience. 54, 8, p. 6691-6695 5 p.

    Research output: Contribution to journalEditorialResearchpeer-review

  34. Published

    NREM sleep upregulates human brain pulsation detected by Ultrafast Magnetic Resonance Encephalography

    Larsen, S. M. U., Holst, S. C., Olsen, A. S., Zilstorff, D. B., Pleinert, S., Kiviniemi, V., Jennum, Poul, Nedergaard, Maiken & Knudsen, Gitte Moos, 2021, In: European Neuropsychopharmacology. 53, p. S361-S362 3 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  35. Published

    Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes

    Li, J., Pan, L., Pembroke, W. G., Rexach, J. E., Godoy, M. I., Condro, M. C., Alvarado, A. G., Harteni, M., Chen, Y., Stiles, L., Chen, A. Y., Wanner, I. B., Yang, X., Goldman, Steven Alan, Geschwind, D. H., Kornblum, H. I. & Zhang, Y., 2021, p. E172-E173. 2 p.

    Research output: Contribution to conferencePosterResearchpeer-review

  36. Published

    Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes

    Li, J., Pan, L., Godoy, M., Pembroke, W. G., Rexach, J. E., Condro, M. C., Alvarado, A. G., Harteni, M., Chen, Y., Stiles, L., Chen, A. Y., Wanner, I. B., Yang, X., Goldman, Steven Alan, Geschwind, D. H., Kornblum, H. & Zhang, Y., 2021, In: Nature Communications. 12, 1, 20 p., 3958.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Development of the entorhinal cortex occurs via parallel lamination during neurogenesis

    Liu, Y., Bergmann, T., Mori, Yuki, Peralvo Vidal, Juan Miguel, Pihl, M., Vasistha, Navneet A, Thomsen, Preben Dybdahl, Seemann, Ernst Stefan, Gorodkin, Jan, Hyttel, P., Khodosevich, Konstantin, Witter, M. P. & Hall, Vanessa Jane, 2021, In: Frontiers in Neuroanatomy. 15, 19 p., 663667.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update

    Lovell-Badge, R., Anthony, E., Barker, R. A., Bubela, T., Brivanlou, A. H., Carpenter, M., Charo, R. A., Clark, A., Clayton, E., Cong, Y., Daley, G. Q., Fu, J., Fujita, M., Greenfield, A., Goldman, S. A., Hill, L., Hyun, I., Isasi, R., Kahn, J., Kato, K. & 27 others, Kim, J. S., Kimmelman, J., Knoblich, J. A., Mathews, D., Montserrat, N., Mosher, J., Munsie, M., Nakauchi, H., Naldini, L., Naughton, G., Niakan, K., Ogbogu, U., Pedersen, R., Rivron, N., Rooke, H., Rossant, J., Round, J., Saitou, M., Sipp, D., Steffann, J., Sugarman, J., Surani, A., Takahashi, J., Tang, F., Turner, L., Zettler, P. J. & Zhai, X., 2021, In: Stem Cell Reports. 16, 6, p. 1398-1408 11 p.

    Research output: Contribution to journalReviewResearchpeer-review

  39. Published

    The Glymphatic System (En)during Inflammation

    Mogensen, F. L., Delle, Christine & Nedergaard, Maiken, 2021, In: International Journal of Molecular Sciences. 22, 14, 20 p., 7491.

    Research output: Contribution to journalReviewResearchpeer-review

  40. Published

    Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization

    Monai, H., Koketsu, S., Shinohara, Y., Ueki, T., Kusk, P., Hauglund, Natalie Linea, Samson, A. J., Nedergaard, Maiken & Hirase, Hajime, 2021, In: Scientific Reports. 11, 1, 8150.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Lung megakaryocytes are immune modulatory cells

    Pariser, D. N., Hilt, Z. T., Ture, S. K., Blick-Nitko, S. K., Looney, M. R., Cleary, S. J., Roman-Pagan, E., Saunders, J., Georas, S. N., Veazey, J., Madere, F., Santos, L. T., Arne, A., Huynh, N. P. T., Livada, A. C., Guerrero-Martin, S. M., Lyons, C., Metcalf-Pate, K. A., McGrath, K. E., Palis, J. & 1 others, Morrell, C. N., 2021, In: Journal of Clinical Investigation. 131, 1, e137377.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Human iPSC-derived neural precursor cells differentiate into multiple cell types to delay disease progression following transplantation into YAC128 Huntington's disease mouse model

    Park, H. J., Jeon, J., Choi, J., Kim, J. Y., Kim, H. S., Huh, J. Y., Goldman, Steven Alan & Song, J., 2021, In: Cell Proliferation. 54, 8, 16 p., e13082.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Changes in visual processing during progression of Tau accumulation and neurodegeneration in a mouse model of human tauopathy

    Parka, A., Nedergaard, Maiken, Sotty, F. & Laursen, B., 2021, In: Investigative Ophthalmology & Visual Science. 62, 8, 3 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  44. Published

    DNase treatment prevents CSF block in early experimental pneumococcal meningitis

    Pavan, C., L R Xavier, Anna , Ramos, M., Fisher, J., Kritsilis, M., Linder, A., Bentzer, P., Nedergaard, Maiken & Lundgaard, I., 2021, In: Annals of Neurology. 90, 4, p. 653-669 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Bulk flow of cerebrospinal fluid observed in periarterial spaces is not an artifact of injection

    Raghunandan, A., Ladron-De-guevara, A., Tithof, J., Mestre, H., Du, T., Nedergaard, Maiken, Thomas, J. H. & Kelley, D. H., 2021, In: eLife. 10, 15 p., e65958.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Twists and turns of ocular glymphatic clearance – new study reveals surprising findings in glaucoma

    Rangroo Thrane, V., Hynnekleiv, L., Wang, X., Thrane, A. S., Krohn, J. & Nedergaard, Maiken, 2021, In: Acta Ophthalmologica. 99, 2, p. e283-e284 2 p.

    Research output: Contribution to journalLetterResearchpeer-review

  47. Published

    Cell Therapy for Huntington's Disease: Learning from Failure

    Rosser, A. E., Busse, M., Badin, R. A., Canals, J. M., Wheelock, V., Perrier, A. L., Gray, W., Thompson, L. & Goldman, Steven Alan, 2021, In: Movement Disorders. 36, 3, p. 787-788 2 p.

    Research output: Contribution to journalLetterResearchpeer-review

  48. Published

    Mapping of CSF transport using high spatiotemporal resolution dynamic contrast-enhanced MRI in mice: Effect of anesthesia

    Stanton, E. H., Persson, N. D. Å., Gomolka, Ryszard Stefan, Lilius, T., Sigurðsson, B., Lee, H., L R Xavier, Anna , Benveniste, H., Nedergaard, Maiken & Mori, Yuki, 2021, In: Magnetic Resonance in Medicine. 85, 6, p. 3326-3342 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Measuring Shape Relations Using r-Parallel Sets

    Stephensen, Hans Jacob Teglbjærg, Svane, A. M., Villanueva, C. B., Goldman, Steven Alan & Sporring, Jon, 2021, In: Journal of Mathematical Imaging and Vision. 63, p. 1069–1083 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    The Ser19Stop single nucleotide polymorphism (SNP) of human PHYHIPL affects the cerebellum in mice

    Sugimoto, H., Horii, T., Hirota, J. N., Sano, Y., Shinoda, Y., Konno, A., Hirai, H., Ishizaki, Y., Hirase, Hajime, Hatada, I., Furuichi, T. & Sadakata, T., 2021, In: Molecular Brain. 14, 1, 9 p., 52.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Astroglia in Neuropsychiatric Disorders

    Verkhratsky, A., 2021, In: Neuroendocrinology. 111, Supplement 1, p. 4 1 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  52. Published

    Reply to: Rethink the classical view of cerebrospinal fluid production

    Wardlaw, J. M., Benveniste, H., Nedergaard, Maiken, Zlokovic, B. V., Charpak, S., Smith, K. J. & Black, S. E., 2021, In: Nature Reviews Neurology. 17, 9, p. 590-591

    Research output: Contribution to journalLetterResearchpeer-review