Glial progenitor cell-based repair of the dysmyelinated brain: Progression to the clinic
Research output: Contribution to journal › Review › Research › peer-review
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Accepted author manuscript, 2.31 MB, PDF document
Demyelinating disorders of the central white matter are among the most prevalent and disabling conditions in neurology. Since myelin-producing oligodendrocytes comprise the principal cell type deficient or lost in these conditions, their replacement by new cells generated from transplanted bipotential oligodendrocyte-astrocyte progenitor cells has emerged as a therapeutic strategy for a variety of primary dysmyelinating diseases. In this review, we summarize the research and clinical considerations supporting current efforts to bring this treatment approach to patients.
Original language | English |
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Journal | Seminars in Cell and Developmental Biology |
Volume | 116 |
Pages (from-to) | 62-70 |
Number of pages | 9 |
ISSN | 1084-9521 |
DOIs | |
Publication status | Published - 2021 |
- EMBRYONIC STEM-CELLS, WHITE-MATTER, HUMAN OLIGODENDROCYTES, BASIC-PROTEIN, MICE, GENERATION, MYELINATE, THERAPY, RESCUE, CNS
Research areas
ID: 275123731