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About the Center for Basic and Translational Neuroscience
The heads of the Center for Basic and Translational Neuroscience are Professor Maiken Nedergaard and Professor Steve Goldman.
Professor Steve Goldman is internationally recognized for his innovative work using glia progenitors to repair myelin in models of several demyelinating diseases, including MS.
Professor Maiken Nedergaard is known around the world due to her recent research published in Science showing how sleep rids the brain of some of the proteins connected to dementia.
New Approaches for Treating Neurological Diseases
The Center for Basic and Translational Neuroscience focuses on the development of new approaches for treating neurological diseases, primarily using cell and gene therapy. Our emphasis is on using these technologies to mobilize endogenous stem and progenitor cells of the adult brain and spinal cord, as a means of structural repair. In addition, stem cell isolation and genomics analysis, as well as advanced imaging and transplant strategies are also pursued, both for biological assessment and therapeutic modeling. Our disease targets are those attributable to dysfunction or loss of single cell types; for instance, demyelinating disease is studied as a potential target for oligodendrocyte progenitor cell delivery, while Huntington’s Disease is studied as a potential beneficiary of medium spiny neuronal replacement from endogenous stem cells. Conversely, gliomas and gliomagenesis are studied from the standpoint of dysregulated signaling by endogenous glial progenitors. The principal groups in the Center include Dr. Goldman’s, whose division focuses on neural stem and glial progenitor biology, and Dr. Nedergaard’s, whose division focuses on astrocytic physiology and pathology, as well as on cerebral blood flow and its glial regulation.
The center is funded by a 80 million DKK grant from the Novo Nordisk Foundation. The goal is to accelerate the process of bringing the newest research from the lab and into the treatment of patients.
Focus on cell replacement, tumorigenesis, and myelin disease
- Developing an Atlas of Gene Expression by Human Neural Stem and Progenitor Cells
- Transcriptional and Pathway Regulation of Human Glial Tumor Stem Cells
- Transcriptional Events in Remyelination by Human Oligodendrocyte Progenitors
- Inducing Endogenous Progenitors as a Means of Treatment in Huntington’s Disease
- Use of hiPSC and hESC-derived Neural Progenitors for Modeling Neuropsychiatric Disease
- Glial Progenitor-based Cell Therapy in Myelin Disease
Focus on sleep, stroke and traumatic brain and spinal cord injury
- Neuro-glia Interactions
- Glymphatic System
- Evolutionary Changes of Astrocytes
- Functional Hyperemia and the Contribution of Astrocytes to the Regulation of Cerebral Blood Flow
- Glial Responses to Traumatic Brain Injury, Stroke, the Role of Gliosis
- Spinal Cord Injury
- Chronic Pain