About the Center – University of Copenhagen

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About the Center for Basic and Translational Neuroscience

Leadership

The heads of the Center for Basic and Translational Neuroscience are Professor Maiken Nedergaard and Professor Steve Goldman.

Professor Steve Goldman


Professor Steve Goldman is internationally recognized for his innovative work using glia progenitors to repair myelin in models of several demyelinating diseases, including MS.
Read about Steve Goldman and see publications.

Professor Maiken Nedergaard


Professor Maiken Nedergaard is known around the world due to her recent research published in Science showing how sleep rids the brain of some of the proteins connected to dementia. 
Read about Maiken Nedergaard and see publications.

New Approaches for Treating Neurological Diseases

The Center for Basic and Translational Neuroscience focuses on the development of new approaches for treating neurological diseases, primarily using cell and gene therapy. Our emphasis is on using these technologies to mobilize endogenous stem and progenitor cells of the adult brain and spinal cord, as a means of structural repair. In addition, stem cell isolation and genomics analysis, as well as advanced imaging and transplant strategies are also pursued, both for biological assessment and therapeutic modeling. Our disease targets are those attributable to dysfunction or loss of single cell types; for instance, demyelinating disease is studied as a potential target for oligodendrocyte progenitor cell delivery, while Huntington’s Disease is studied as a potential beneficiary of medium spiny neuronal replacement from endogenous stem cells. Conversely, gliomas and gliomagenesis are studied from the standpoint of dysregulated signaling by endogenous glial progenitors. The principal groups in the Center include Dr. Goldman’s, whose division focuses on neural stem and glial progenitor biology, and Dr. Nedergaard’s, whose division focuses on astrocytic physiology and pathology, as well as on cerebral blood flow and its glial regulation.

Funding

The center is funded by a 80 million DKK grant from the Novo Nordisk Foundation. The goal is to accelerate the process of bringing the newest research from the lab and into the treatment of patients.

Research Overview

Division of Cell and Gene Therapy (Goldman Lab)


Focus on cell replacement, tumorigenesis, and myelin disease

Division of Glial Therapeutics (Nedergaard Lab)


Focus on sleep, stroke and traumatic brain and spinal cord injury