The Center for Basic and Translational Neuroscience focuses on the development of new approaches for understanding and treating neurological disease, with an emphasis on glial cell biology.
The Goldman Lab – Division of Cell and Gene Therapy – uses cell and gene therapy approaches to mobilize endogenous neural stem and progenitor cells of the adult brain, as a means of structural repair. Stem cell isolation and genomics analysis, as well as advanced imaging and transplant strategies are pursued for both biological assessment and therapeutic modeling. Disease targets include the myelin disorders, in particular multiple sclerosis and the leukodystrophies, and those neurodegenerative and psychiatric disorders that have significant glial pathology, such as Huntington disease and schizophrenia. In addition, glial cell tumors are studied, from the standpoint of dysregulated signaling by glial progenitors.
The Nedergaard Lab – Division of Glial Disease and Therapeutics – focuses on understanding the role of astrocytes in higher information processing, as well as in the perception of pain, reaction to acute injury, and the sleep-wake cycle. In addition, the group is intensively investigating the glymphatic system, as both a contributor to and therapeutic target in small vessel disease and neurodegenerative diseases. To these ends, the group combines advanced imaging (multiphoton imaging, 9.4T MRI, CT-PET, and real-time macroscopy) together with electrophysiological approaches (CoEG, extracellular ion concentrations, patch clamp) in studies of awake behaving mice.
RECENT PUBLICATIONS (2016)
Liang Q. et al. Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy Cell Stem Cell. 19, 663-671. 2016 Nov 03.
Bosetti F et al. "Small Blood Vessels: Big Health Problems?": Scientific Recommendations of the National Institutes of Health Workshop. Journal of American Heart Association, 2016 nov 04.
Wang F. et al. "NKCC1 up-regulation contributes to early post-traumatic seizures and increased post-traumatic seizure susceptibility." Brain structure & function. 2016 Sep 1; Epub 2016 Sep 01.
Osorio MJ, Goldman SA. "Glial progenitor cell-based treatment of the childhood leukodystrophies." Experimental neurology. 2016 Sep; 283(Pt B):476-88. Epub 2016 May 08.
Wang Y. et al. "3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice." Nature medicine. 2016 Sep; 22(9):1050-5. Epub 2016 Aug 22.
McConnell ED et al. "Cerebral microcirculatory failure after subarachnoid hemorrhage is reversed by hyaluronidase." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2016 Sep; 36(9):1537-52. Epub 2015 Oct 14.
Peng W. et al. "Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease." Neurobiology of disease. 2016 Sep; 93:215-25. Epub 2016 May 24.
Wei HS. et al. "Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation." Neuron. 2016 Aug 17; 91(4):851-62. Epub 2016 Aug 04.
Verkhratsky A, Nedergaard M. "The homeostatic astroglia emerges from evolutionary specialization of neural cells." Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 2016 Aug 5; 371(1700)
Liang Q. et al. "Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy." Cell stem cell. 2016 Aug 9; Epub 2016 Aug 09.
Lundgaard I. et al. "Glymphatic clearance controls state-dependent changes in brain lactate concentration." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2016 Aug 1; Epub 2016 Aug 01.