Transient Astrocytic Gq Signaling Underlies Remote Memory Enhancement

Research output: Contribution to journal › Journal article › Research › peer-review

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Transient Astrocytic Gq Signaling Underlies Remote Memory Enhancement. / Iwai, Youichi; Ozawa, Katsuya; Yahagi, Kazuko; Mishima, Tsuneko; Akther, Sonam; Vo, Camilla Trang; Lee, Ashley Bomin; Tanaka, Mika; Itohara, Shigeyoshi; Hirase, Hajime.

In: Frontiers in Neural Circuits, Vol. 15, 658343, 2021.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Iwai, Y, Ozawa, K, Yahagi, K, Mishima, T, Akther, S, Vo, CT, Lee, AB, Tanaka, M, Itohara, S & Hirase, H 2021, 'Transient Astrocytic Gq Signaling Underlies Remote Memory Enhancement', Frontiers in Neural Circuits, vol. 15, 658343. https://doi.org/10.3389/fncir.2021.658343

APA

Iwai, Y., Ozawa, K., Yahagi, K., Mishima, T., Akther, S., Vo, C. T., Lee, A. B., Tanaka, M., Itohara, S., & Hirase, H. (2021). Transient Astrocytic Gq Signaling Underlies Remote Memory Enhancement. Frontiers in Neural Circuits, 15, [658343]. https://doi.org/10.3389/fncir.2021.658343

Vancouver

Iwai Y, Ozawa K, Yahagi K, Mishima T, Akther S, Vo CT et al. Transient Astrocytic Gq Signaling Underlies Remote Memory Enhancement. Frontiers in Neural Circuits. 2021;15. 658343. https://doi.org/10.3389/fncir.2021.658343

Author

Iwai, Youichi ; Ozawa, Katsuya ; Yahagi, Kazuko ; Mishima, Tsuneko ; Akther, Sonam ; Vo, Camilla Trang ; Lee, Ashley Bomin ; Tanaka, Mika ; Itohara, Shigeyoshi ; Hirase, Hajime. / Transient Astrocytic Gq Signaling Underlies Remote Memory Enhancement. In: Frontiers in Neural Circuits. 2021 ; Vol. 15.

Bibtex

@article{1123bf40a88941809a022257340eb3bd,
title = "Transient Astrocytic Gq Signaling Underlies Remote Memory Enhancement",
abstract = "Astrocytes elicit transient Ca2+ elevations induced by G protein-coupled receptors (GPCRs), yet their role in vivo remains unknown. To address this, transgenic mice with astrocytic expression of the optogenetic Gq-type GPCR, Optoα1AR, were established, in which transient Ca2+ elevations similar to those in wild type mice were induced by brief blue light illumination. Activation of cortical astrocytes resulted in an adenosine A1 receptor-dependent inhibition of neuronal activity. Moreover, sensory stimulation with astrocytic activation induced long-term depression of sensory evoked response. At the behavioral level, repeated astrocytic activation in the anterior cortex gradually affected novel open field exploratory behavior, and remote memory was enhanced in a novel object recognition task. These effects were blocked by A1 receptor antagonism. Together, we demonstrate that GPCR-triggered Ca2+ elevation in cortical astrocytes has causal impacts on neuronal activity and behavior.",
keywords = "astrocytes, Ca signaling, G protein-coupled receptor, memory, OptoA1AR, optogenetic activation",
author = "Youichi Iwai and Katsuya Ozawa and Kazuko Yahagi and Tsuneko Mishima and Sonam Akther and Vo, {Camilla Trang} and Lee, {Ashley Bomin} and Mika Tanaka and Shigeyoshi Itohara and Hajime Hirase",
year = "2021",
doi = "10.3389/fncir.2021.658343",
language = "English",
volume = "15",
journal = "Frontiers in Neural Circuits",
issn = "1662-5110",
publisher = "Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - Transient Astrocytic Gq Signaling Underlies Remote Memory Enhancement

AU - Iwai, Youichi

AU - Ozawa, Katsuya

AU - Yahagi, Kazuko

AU - Mishima, Tsuneko

AU - Akther, Sonam

AU - Vo, Camilla Trang

AU - Lee, Ashley Bomin

AU - Tanaka, Mika

AU - Itohara, Shigeyoshi

AU - Hirase, Hajime

PY - 2021

Y1 - 2021

N2 - Astrocytes elicit transient Ca2+ elevations induced by G protein-coupled receptors (GPCRs), yet their role in vivo remains unknown. To address this, transgenic mice with astrocytic expression of the optogenetic Gq-type GPCR, Optoα1AR, were established, in which transient Ca2+ elevations similar to those in wild type mice were induced by brief blue light illumination. Activation of cortical astrocytes resulted in an adenosine A1 receptor-dependent inhibition of neuronal activity. Moreover, sensory stimulation with astrocytic activation induced long-term depression of sensory evoked response. At the behavioral level, repeated astrocytic activation in the anterior cortex gradually affected novel open field exploratory behavior, and remote memory was enhanced in a novel object recognition task. These effects were blocked by A1 receptor antagonism. Together, we demonstrate that GPCR-triggered Ca2+ elevation in cortical astrocytes has causal impacts on neuronal activity and behavior.

AB - Astrocytes elicit transient Ca2+ elevations induced by G protein-coupled receptors (GPCRs), yet their role in vivo remains unknown. To address this, transgenic mice with astrocytic expression of the optogenetic Gq-type GPCR, Optoα1AR, were established, in which transient Ca2+ elevations similar to those in wild type mice were induced by brief blue light illumination. Activation of cortical astrocytes resulted in an adenosine A1 receptor-dependent inhibition of neuronal activity. Moreover, sensory stimulation with astrocytic activation induced long-term depression of sensory evoked response. At the behavioral level, repeated astrocytic activation in the anterior cortex gradually affected novel open field exploratory behavior, and remote memory was enhanced in a novel object recognition task. These effects were blocked by A1 receptor antagonism. Together, we demonstrate that GPCR-triggered Ca2+ elevation in cortical astrocytes has causal impacts on neuronal activity and behavior.

KW - astrocytes

KW - Ca signaling

KW - G protein-coupled receptor

KW - memory

KW - OptoA1AR

KW - optogenetic activation

U2 - 10.3389/fncir.2021.658343

DO - 10.3389/fncir.2021.658343

M3 - Journal article

C2 - 33828463

AN - SCOPUS:85103645083

VL - 15

JO - Frontiers in Neural Circuits

JF - Frontiers in Neural Circuits

SN - 1662-5110

M1 - 658343

ER -

ID: 260516592