The role of glial pathology in Huntington's disease
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
This review will focus on the contribution of glial pathology to HD, particularly so with regard to diseased glial progenitor cells and their derived astrocytes and oligodendrocytes. It will briefly discuss the body of data identifying the contribution of glial dysfunction to disease phenotype in rodent models of HD, and will then focus on recent studies of cell-intrinsic glial transcriptional dysregulation in HD. The review will emphasize recent studies of diseased human cells and humanized models of HD glial pathology, and on the contributions of that glial pathology to neuronal and synaptic dysfunction in HD.
Original language | English |
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Title of host publication | Huntington's Disease : Pathogenic Mechanisms and Implications for Therapeutics |
Number of pages | 15 |
Publisher | Elsevier |
Publication date | 2024 |
Pages | 337-351 |
Chapter | 14 |
ISBN (Print) | 9780323956734 |
ISBN (Electronic) | 9780323956727 |
DOIs | |
Publication status | Published - 2024 |
Bibliographical note
Publisher Copyright:
© 2024 Elsevier Inc. All rights reserved.
- Astrocytes, Glia, hESC, Huntington's disease, Myelin, OLIG2, Oligodendrocytes, Stem cell, TCF7L2
Research areas
ID: 388544940