The role of glial pathology in Huntington's disease

Center for Translational Neuromedicine

The role of glial pathology in Huntington's disease

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Standard

The role of glial pathology in Huntington's disease. / Goldman, Steven A.

Huntington's Disease: Pathogenic Mechanisms and Implications for Therapeutics. Elsevier, 2024. p. 337-351.

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Harvard

Goldman, SA 2024, The role of glial pathology in Huntington's disease. in Huntington's Disease: Pathogenic Mechanisms and Implications for Therapeutics. Elsevier, pp. 337-351. https://doi.org/10.1016/B978-0-323-95672-7.00020-0

APA

Goldman, S. A. (2024). The role of glial pathology in Huntington's disease. In Huntington's Disease: Pathogenic Mechanisms and Implications for Therapeutics (pp. 337-351). Elsevier. https://doi.org/10.1016/B978-0-323-95672-7.00020-0

Vancouver

Goldman SA. The role of glial pathology in Huntington's disease. In Huntington's Disease: Pathogenic Mechanisms and Implications for Therapeutics. Elsevier. 2024. p. 337-351 https://doi.org/10.1016/B978-0-323-95672-7.00020-0

Author

Goldman, Steven A. / The role of glial pathology in Huntington's disease. Huntington's Disease: Pathogenic Mechanisms and Implications for Therapeutics. Elsevier, 2024. pp. 337-351

Bibtex

@inbook{51eaf60a7e094ced9746c6bd1cb9253e,

title = "The role of glial pathology in Huntington's disease",

abstract = "This review will focus on the contribution of glial pathology to HD, particularly so with regard to diseased glial progenitor cells and their derived astrocytes and oligodendrocytes. It will briefly discuss the body of data identifying the contribution of glial dysfunction to disease phenotype in rodent models of HD, and will then focus on recent studies of cell-intrinsic glial transcriptional dysregulation in HD. The review will emphasize recent studies of diseased human cells and humanized models of HD glial pathology, and on the contributions of that glial pathology to neuronal and synaptic dysfunction in HD.",

keywords = "Astrocytes, Glia, hESC, Huntington's disease, Myelin, OLIG2, Oligodendrocytes, Stem cell, TCF7L2",

author = "Goldman, {Steven A.}",

year = "2024",

doi = "10.1016/B978-0-323-95672-7.00020-0",

language = "English",

isbn = "9780323956734",

pages = "337--351",

booktitle = "Huntington's Disease",

publisher = "Elsevier",

}

RIS

TY - CHAP

T1 - The role of glial pathology in Huntington's disease

AU - Goldman, Steven A.

PY - 2024

Y1 - 2024

N2 - This review will focus on the contribution of glial pathology to HD, particularly so with regard to diseased glial progenitor cells and their derived astrocytes and oligodendrocytes. It will briefly discuss the body of data identifying the contribution of glial dysfunction to disease phenotype in rodent models of HD, and will then focus on recent studies of cell-intrinsic glial transcriptional dysregulation in HD. The review will emphasize recent studies of diseased human cells and humanized models of HD glial pathology, and on the contributions of that glial pathology to neuronal and synaptic dysfunction in HD.

AB - This review will focus on the contribution of glial pathology to HD, particularly so with regard to diseased glial progenitor cells and their derived astrocytes and oligodendrocytes. It will briefly discuss the body of data identifying the contribution of glial dysfunction to disease phenotype in rodent models of HD, and will then focus on recent studies of cell-intrinsic glial transcriptional dysregulation in HD. The review will emphasize recent studies of diseased human cells and humanized models of HD glial pathology, and on the contributions of that glial pathology to neuronal and synaptic dysfunction in HD.

KW - Astrocytes

KW - Glia

KW - hESC

KW - Huntington's disease

KW - Myelin

KW - OLIG2

KW - Oligodendrocytes

KW - Stem cell

KW - TCF7L2

U2 - 10.1016/B978-0-323-95672-7.00020-0

DO - 10.1016/B978-0-323-95672-7.00020-0

M3 - Book chapter

AN - SCOPUS:85189580978

SN - 9780323956734

SP - 337

EP - 351

BT - Huntington's Disease

PB - Elsevier

ER -

ID: 388544940