The Glymphatic System (En)during Inflammation

Research output: Contribution to journal › Review › Research › peer-review

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The Glymphatic System (En)during Inflammation. / Mogensen, Frida Lind-Holm; Delle, Christine; Nedergaard, Maiken.

In: International Journal of Molecular Sciences, Vol. 22, No. 14, 7491, 2021.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Mogensen, FL-H, Delle, C & Nedergaard, M 2021, 'The Glymphatic System (En)during Inflammation', International Journal of Molecular Sciences, vol. 22, no. 14, 7491. https://doi.org/10.3390/ijms22147491

APA

Mogensen, F. L-H., Delle, C., & Nedergaard, M. (2021). The Glymphatic System (En)during Inflammation. International Journal of Molecular Sciences, 22(14), [7491]. https://doi.org/10.3390/ijms22147491

Vancouver

Mogensen FL-H, Delle C, Nedergaard M. The Glymphatic System (En)during Inflammation. International Journal of Molecular Sciences. 2021;22(14). 7491. https://doi.org/10.3390/ijms22147491

Author

Mogensen, Frida Lind-Holm ; Delle, Christine ; Nedergaard, Maiken. / The Glymphatic System (En)during Inflammation. In: International Journal of Molecular Sciences. 2021 ; Vol. 22, No. 14.

Bibtex

@article{49e4f0f43eec43fa843114c9bf6c2a85,
title = "The Glymphatic System (En)during Inflammation",
abstract = "The glymphatic system is a fluid-transport system that accesses all regions of the brain. It facilitates the exchange of cerebrospinal fluid and interstitial fluid and clears waste from the metabolically active brain. Astrocytic endfeet and their dense expression of the aquaporin-4 water channels promote fluid exchange between the perivascular spaces and the neuropil. Cerebrospinal and interstitial fluids are together transported back to the vascular compartment by meningeal and cervical lymphatic vessels. Multiple lines of work show that neurological diseases in general impair glymphatic fluid transport. Insofar as the glymphatic system plays a pseudo-lymphatic role in the central nervous system, it is poised to play a role in neuroinflammation. In this review, we discuss how the association of the glymphatic system with the meningeal lymphatic vessel calls for a renewal of established concepts on the CNS as an immune-privileged site. We also discuss potential approaches to target the glymphatic system to combat neuroinflammation.",
keywords = "glymphatic system, astrocytes, glia limitans, AQP4, ocular glymphatic system, inflammation, immune privilege, CSF, ISF, immune surveillance, EXPERIMENTAL RETINAL-DETACHMENT, BLOOD-BRAIN-BARRIER, NEUROMYELITIS-OPTICA, IMMUNE-SYSTEM, CHOROID-PLEXUS, T-CELLS, EXTRACELLULAR FLUID, COGNITIVE DEFICITS, INTERSTITIAL FLUID, CERVICAL LYMPH",
author = "Mogensen, {Frida Lind-Holm} and Christine Delle and Maiken Nedergaard",
year = "2021",
doi = "10.3390/ijms22147491",
language = "English",
volume = "22",
journal = "International Journal of Molecular Sciences (Online)",
issn = "1661-6596",
publisher = "MDPI AG",
number = "14",

}

RIS

TY - JOUR

T1 - The Glymphatic System (En)during Inflammation

AU - Mogensen, Frida Lind-Holm

AU - Delle, Christine

AU - Nedergaard, Maiken

PY - 2021

Y1 - 2021

N2 - The glymphatic system is a fluid-transport system that accesses all regions of the brain. It facilitates the exchange of cerebrospinal fluid and interstitial fluid and clears waste from the metabolically active brain. Astrocytic endfeet and their dense expression of the aquaporin-4 water channels promote fluid exchange between the perivascular spaces and the neuropil. Cerebrospinal and interstitial fluids are together transported back to the vascular compartment by meningeal and cervical lymphatic vessels. Multiple lines of work show that neurological diseases in general impair glymphatic fluid transport. Insofar as the glymphatic system plays a pseudo-lymphatic role in the central nervous system, it is poised to play a role in neuroinflammation. In this review, we discuss how the association of the glymphatic system with the meningeal lymphatic vessel calls for a renewal of established concepts on the CNS as an immune-privileged site. We also discuss potential approaches to target the glymphatic system to combat neuroinflammation.

AB - The glymphatic system is a fluid-transport system that accesses all regions of the brain. It facilitates the exchange of cerebrospinal fluid and interstitial fluid and clears waste from the metabolically active brain. Astrocytic endfeet and their dense expression of the aquaporin-4 water channels promote fluid exchange between the perivascular spaces and the neuropil. Cerebrospinal and interstitial fluids are together transported back to the vascular compartment by meningeal and cervical lymphatic vessels. Multiple lines of work show that neurological diseases in general impair glymphatic fluid transport. Insofar as the glymphatic system plays a pseudo-lymphatic role in the central nervous system, it is poised to play a role in neuroinflammation. In this review, we discuss how the association of the glymphatic system with the meningeal lymphatic vessel calls for a renewal of established concepts on the CNS as an immune-privileged site. We also discuss potential approaches to target the glymphatic system to combat neuroinflammation.

KW - glymphatic system

KW - astrocytes

KW - glia limitans

KW - AQP4

KW - ocular glymphatic system

KW - inflammation

KW - immune privilege

KW - CSF

KW - ISF

KW - immune surveillance

KW - EXPERIMENTAL RETINAL-DETACHMENT

KW - BLOOD-BRAIN-BARRIER

KW - NEUROMYELITIS-OPTICA

KW - IMMUNE-SYSTEM

KW - CHOROID-PLEXUS

KW - T-CELLS

KW - EXTRACELLULAR FLUID

KW - COGNITIVE DEFICITS

KW - INTERSTITIAL FLUID

KW - CERVICAL LYMPH

U2 - 10.3390/ijms22147491

DO - 10.3390/ijms22147491

M3 - Review

C2 - 34299111

VL - 22

JO - International Journal of Molecular Sciences (Online)

JF - International Journal of Molecular Sciences (Online)

SN - 1661-6596

IS - 14

M1 - 7491

ER -

ID: 275266248