The Brain's Glymphatic System

Center for Translational Neuromedicine

The Brain's Glymphatic System: Current Controversies

Research output: Contribution to journal › Review › Research › peer-review

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The Brain's Glymphatic System : Current Controversies. / Mestre, Humberto; Mori, Yuki; Nedergaard, Maiken.

In: Trends in Neurosciences, Vol. 43, No. 7, 2020, p. 458-466.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Mestre, H, Mori, Y & Nedergaard, M 2020, 'The Brain's Glymphatic System: Current Controversies', Trends in Neurosciences, vol. 43, no. 7, pp. 458-466. https://doi.org/10.1016/j.tins.2020.04.003

APA

Mestre, H., Mori, Y., & Nedergaard, M. (2020). The Brain's Glymphatic System: Current Controversies. Trends in Neurosciences, 43(7), 458-466. https://doi.org/10.1016/j.tins.2020.04.003

Vancouver

Mestre H, Mori Y, Nedergaard M. The Brain's Glymphatic System: Current Controversies. Trends in Neurosciences. 2020;43(7):458-466. https://doi.org/10.1016/j.tins.2020.04.003

Author

Mestre, Humberto ; Mori, Yuki ; Nedergaard, Maiken. / The Brain's Glymphatic System : Current Controversies. In: Trends in Neurosciences. 2020 ; Vol. 43, No. 7. pp. 458-466.

Bibtex

@article{9d0169a1b0bd46e6906fbdfe927eb187,

title = "The Brain's Glymphatic System: Current Controversies",

abstract = "The glymphatic concept along with the discovery of meningeal lymphatic vessels have, in recent years, highlighted that fluid is directionally transported within the central nervous system (CNS). Imaging studies, as well as manipulations of fluid transport, point to a key role of the glymphatic–lymphatic system in clearance of amyloid-β and other proteins. As such, the glymphatic–lymphatic system represents a new target in combating neurodegenerative diseases. Not unexpectedly, introduction of a new plumbing system in the brain has stirred controversies. This opinion article will highlight what we know about the brain's fluid transport systems, where experimental data are lacking, and what is still debated.",

keywords = "amyloid-β, aquaporin-4, brain clearance, cerebrospinal fluid, glymphatic system, meningeal lymphatics, perivascular spaces",

author = "Humberto Mestre and Yuki Mori and Maiken Nedergaard",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s)",

year = "2020",

doi = "10.1016/j.tins.2020.04.003",

language = "English",

volume = "43",

pages = "458--466",

journal = "Trends in Neurosciences",

issn = "0378-5912",

publisher = "Elsevier Ltd. * Trends Journals",

number = "7",

}

RIS

TY - JOUR

T1 - The Brain's Glymphatic System

T2 - Current Controversies

AU - Mestre, Humberto

AU - Mori, Yuki

AU - Nedergaard, Maiken

PY - 2020

Y1 - 2020

N2 - The glymphatic concept along with the discovery of meningeal lymphatic vessels have, in recent years, highlighted that fluid is directionally transported within the central nervous system (CNS). Imaging studies, as well as manipulations of fluid transport, point to a key role of the glymphatic–lymphatic system in clearance of amyloid-β and other proteins. As such, the glymphatic–lymphatic system represents a new target in combating neurodegenerative diseases. Not unexpectedly, introduction of a new plumbing system in the brain has stirred controversies. This opinion article will highlight what we know about the brain's fluid transport systems, where experimental data are lacking, and what is still debated.

AB - The glymphatic concept along with the discovery of meningeal lymphatic vessels have, in recent years, highlighted that fluid is directionally transported within the central nervous system (CNS). Imaging studies, as well as manipulations of fluid transport, point to a key role of the glymphatic–lymphatic system in clearance of amyloid-β and other proteins. As such, the glymphatic–lymphatic system represents a new target in combating neurodegenerative diseases. Not unexpectedly, introduction of a new plumbing system in the brain has stirred controversies. This opinion article will highlight what we know about the brain's fluid transport systems, where experimental data are lacking, and what is still debated.

KW - amyloid-β

KW - aquaporin-4

KW - brain clearance

KW - cerebrospinal fluid

KW - glymphatic system

KW - meningeal lymphatics

KW - perivascular spaces

U2 - 10.1016/j.tins.2020.04.003

DO - 10.1016/j.tins.2020.04.003

M3 - Review

C2 - 32423764

AN - SCOPUS:85084601804

VL - 43

SP - 458

EP - 466

JO - Trends in Neurosciences

JF - Trends in Neurosciences

SN - 0378-5912

IS - 7

ER -

ID: 269518530