The Brain's Glymphatic System: Current Controversies
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- The Brain’s Glymphatic System. Current Controversies
Final published version, 1.96 MB, PDF document
The glymphatic concept along with the discovery of meningeal lymphatic vessels have, in recent years, highlighted that fluid is directionally transported within the central nervous system (CNS). Imaging studies, as well as manipulations of fluid transport, point to a key role of the glymphatic–lymphatic system in clearance of amyloid-β and other proteins. As such, the glymphatic–lymphatic system represents a new target in combating neurodegenerative diseases. Not unexpectedly, introduction of a new plumbing system in the brain has stirred controversies. This opinion article will highlight what we know about the brain's fluid transport systems, where experimental data are lacking, and what is still debated.
Original language | English |
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Journal | Trends in Neurosciences |
Volume | 43 |
Issue number | 7 |
Pages (from-to) | 458-466 |
Number of pages | 9 |
ISSN | 0166-2236 |
DOIs | |
Publication status | Published - 2020 |
Bibliographical note
Publisher Copyright:
© 2020 The Author(s)
- amyloid-β, aquaporin-4, brain clearance, cerebrospinal fluid, glymphatic system, meningeal lymphatics, perivascular spaces
Research areas
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