Glial progenitor cell-based repair of the dysmyelinated brain: Progression to the clinic

Research output: Contribution to journal › Review › Research › peer-review

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Glial progenitor cell-based repair of the dysmyelinated brain : Progression to the clinic. / Goldman, Steven A.; Mariani, John N.; Madsen, Pernille M.

In: Seminars in Cell and Developmental Biology, Vol. 116, 2021, p. 62-70.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Goldman, SA, Mariani, JN & Madsen, PM 2021, 'Glial progenitor cell-based repair of the dysmyelinated brain: Progression to the clinic', Seminars in Cell and Developmental Biology, vol. 116, pp. 62-70. https://doi.org/10.1016/j.semcdb.2020.12.004

APA

Goldman, S. A., Mariani, J. N., & Madsen, P. M. (2021). Glial progenitor cell-based repair of the dysmyelinated brain: Progression to the clinic. Seminars in Cell and Developmental Biology, 116, 62-70. https://doi.org/10.1016/j.semcdb.2020.12.004

Vancouver

Goldman SA, Mariani JN, Madsen PM. Glial progenitor cell-based repair of the dysmyelinated brain: Progression to the clinic. Seminars in Cell and Developmental Biology. 2021;116:62-70. https://doi.org/10.1016/j.semcdb.2020.12.004

Author

Goldman, Steven A. ; Mariani, John N. ; Madsen, Pernille M. / Glial progenitor cell-based repair of the dysmyelinated brain : Progression to the clinic. In: Seminars in Cell and Developmental Biology. 2021 ; Vol. 116. pp. 62-70.

Bibtex

@article{31bf2283aed0413fba6ddc1b4fb4dab9,
title = "Glial progenitor cell-based repair of the dysmyelinated brain: Progression to the clinic",
abstract = "Demyelinating disorders of the central white matter are among the most prevalent and disabling conditions in neurology. Since myelin-producing oligodendrocytes comprise the principal cell type deficient or lost in these conditions, their replacement by new cells generated from transplanted bipotential oligodendrocyte-astrocyte progenitor cells has emerged as a therapeutic strategy for a variety of primary dysmyelinating diseases. In this review, we summarize the research and clinical considerations supporting current efforts to bring this treatment approach to patients.",
keywords = "EMBRYONIC STEM-CELLS, WHITE-MATTER, HUMAN OLIGODENDROCYTES, BASIC-PROTEIN, MICE, GENERATION, MYELINATE, THERAPY, RESCUE, CNS",
author = "Goldman, {Steven A.} and Mariani, {John N.} and Madsen, {Pernille M.}",
year = "2021",
doi = "10.1016/j.semcdb.2020.12.004",
language = "English",
volume = "116",
pages = "62--70",
journal = "Seminars in Cell and Developmental Biology",
issn = "1084-9521",
publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - Glial progenitor cell-based repair of the dysmyelinated brain

T2 - Progression to the clinic

AU - Goldman, Steven A.

AU - Mariani, John N.

AU - Madsen, Pernille M.

PY - 2021

Y1 - 2021

N2 - Demyelinating disorders of the central white matter are among the most prevalent and disabling conditions in neurology. Since myelin-producing oligodendrocytes comprise the principal cell type deficient or lost in these conditions, their replacement by new cells generated from transplanted bipotential oligodendrocyte-astrocyte progenitor cells has emerged as a therapeutic strategy for a variety of primary dysmyelinating diseases. In this review, we summarize the research and clinical considerations supporting current efforts to bring this treatment approach to patients.

AB - Demyelinating disorders of the central white matter are among the most prevalent and disabling conditions in neurology. Since myelin-producing oligodendrocytes comprise the principal cell type deficient or lost in these conditions, their replacement by new cells generated from transplanted bipotential oligodendrocyte-astrocyte progenitor cells has emerged as a therapeutic strategy for a variety of primary dysmyelinating diseases. In this review, we summarize the research and clinical considerations supporting current efforts to bring this treatment approach to patients.

KW - EMBRYONIC STEM-CELLS

KW - WHITE-MATTER

KW - HUMAN OLIGODENDROCYTES

KW - BASIC-PROTEIN

KW - MICE

KW - GENERATION

KW - MYELINATE

KW - THERAPY

KW - RESCUE

KW - CNS

U2 - 10.1016/j.semcdb.2020.12.004

DO - 10.1016/j.semcdb.2020.12.004

M3 - Review

C2 - 33414060

VL - 116

SP - 62

EP - 70

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

SN - 1084-9521

ER -

ID: 275123731