All publications for Maiken Nedergaard, M.D., D.M.Sc. and Nedergaard Lab

(Updated Feb 1 2019)


Monai H, Wang X, Yahagi K, Lou N, Mestre H, Xu Q, Abe Y, Yasui M, Iwai Y, Nedergaard M, Hirase H. (2019) Adrenergic receptor antagonism induces neuroprotection and facilitates recovery from acute ischemic stroke. Proc Natl Acad Sci USA. 116(22):11010-11019. PMC6561179

Lilius TO, Blomqvist K, Hauglund NL, Liu G, Staeger FF, Baerentzen S, Du T, Ahlstrom F, Backman JT, Kalso EA, Rauhala PV, Nedergaard M. (2019) Dexmedetomidine glyphatic brain delivery of intrathecally adminstered drugs. J Control Release. 304:29-38. PMID31067483

Munk AS, Wang W, Bèchet NB, Eltanahy AM, Cheng AX, Sigurdsson B, Benraiss A, Mä MA, Kress BT, Kelley DH, Betsholtz C, Møllgård K, Meissner A, Nedergaard M, Lundgaard (2019) PDGF-B Is Required for Development of the Glymphatic System. Cell Rep. 26(11):2955-2969. PMC6447074

Ramos M, Burdom Bechet N, Battistella R, Pavan C, Xavier ALR, Nedergaard M, Lundgaard I. (2019) Cisterna Magna Injection in Rats to Study Glymphatic Function. Methods Mol Biol. 1938: 97-104. PMID30617975

Koundal S, Liu X, Sanggaard S, Mortensen K, Wardlaw J, Nedergaard M, Benveniste H, Lee H. (2019) Brain Morphometry and Longitudinal Relaxation Time of Spontaneously Hypertensive Rats (SHRs) in Early and Intermediate Stages of Hypertension Investigated by 3D VFA-SPGR MRI. Neuroscience. 404:14-26. PMID30690138

Sweeney MD, Montagne A, Sagare AP, Nation DA, Schneider LS, Chui HC, Harrington MG, Pa J, Law M, Wang DJJ, Jacobs RE, Doubal FN, Ramirez J, Black SE, Nedergaard M, Benveniste H, Dichgans M, Iadecola C, Love S, Bath PM, Markus HS, Salman RA, Allan SM, Quinn TJ, Kalaria RN, Werring DJ, Carare RO, Touyz RM, Williams SCR, Moskowitz MA, Katusic ZS, Lutz SE, Lazarov O, Minshall RD, Rehman J, Davis TP, Wellington CL, González HM, Yuan C, Lockhart SN, Hughes TM, Chen CLH, Sachdev P, O'Brien JT, Skoog I, Pantoni L, Gustafson DR, Biessels GJ, Wallin A, Smith EE, Mok V, Wong A, Passmore P, Barkof F, Muller M, Breteler MMB, Román GC, Hamel E, Seshadri S, Gottesman RF, van Buchem MA, Arvanitakis Z, Schneider JA, Drewes LR, Hachinski V, Finch CE, Toga AW, Wardlaw JM, Zlokovic BV. (2019)  Vascular dysfunction-The disregarded partner of Alzheimer's diseaseAlzheimers Dement. 15(1): 158-167. PMC6338083

Hablitz LM, Vinitsky HS, Sun Q, Staeger FF, Sigurdsson B, Mortensen KN, Lilius TO, Nedergaard M. (2019) Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia. Sci Adv. 5(2):eaav5447. PMC6392807

Cai R, Pan C, Ghasemigharagoz A, Todorov MI, Forstera B, Zhao S, Bhatia HS, Parra-Damas A, Mrowka L, Theodourou D, Rempfler M, Xavier ALR, Kress BT, Benakis C, Steinke H, Liebscher S, Bechmann I, Liesz A, Menze B, Kerschensteiner M, Nedergaard M, Erurk A. (2019) Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull-meninges connections. Nat Neurosci. 22:317-327. PMID30598527


Mestre H, Hablitz LM, Xavier AL, Feng W, Zou W, Pu T, Monai H, Murlidharan G, Castellanos Rivera RM, Simon MJ, Pike MM, Pla V, Du T, Kress BT, Wang X, Plog BA, Thrane AS, Lundgaard I, Abe Y, Yasui M, Thomas JH, Xiao M, Hirase H, Asokan A, Iliff JJ and Nedergaard M. (2018) Aquaporin-4-dependent glymphatic solute transport in the rodent brain. eLife. 7. PMC6307855

Kananen J, Tuovinen T, Ansakorpi H, Rytky S, Helakari H, Huotari N, Raitamaa L, Raatikainen V, Rasila A, Borchardt V, Korhonen V, LeVan P, Nedergaard M, Kiviniemi V. (2018) Altered physiological brain variation in drug-resistant epilepsy.  Brain and Behav. 8(9):e01090. PMC6160661

Plog, B.A., Mestre, H., Genaro, O., Sweeney, A., Kenney, H., Cove, A., Dholakia, K., Tithof, J., Nevins, T.D., Lundgaard, I., Du, T, Kelley, DH, Nedergaard, M. (2018) Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain. JCI insight, PMC6237481

Mestre, H., Tithof, J., Du, T., Sog, W., Peng, W., Sweeney, A., Olveda, G., Thomas, J., Nedergaard, M., and Kelley, D.H. (2018) Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension. Nature Comm, PMC6242982

Rasmussen MK, Mestre H, Nedergaard M. (2018) The glymphatic pathway in neurological disorders. Lancet Neurol. 17(11): 1016-1024.PMID30353860

Xavier ALR; Hauglund NL, von Holstein-Rathlou S, Li Q, Sanggaard S, Lou N, Lundgaard I, Nedergaard M. (2018) Cannuala Implantation into the Cisterna Magna of Rodents. J Vis Exp. (135). PMID29889209

Aalling NN, Nedergaard M, DiNuzzo M. (2018) Cerebral Metabolic Changes During Sleep. Current Neurol Neurosci Rep. 18(9):57. PMID30014344

Obara-Michlewska M, Ding F, Popek M, Verkhratsky A, Nedergaard M, Zielinska M, Albrecht J. (2018) Interstitial ion homeostasis and acid-base balance are maintained in oedematous brain of mice with acute toxic liver failure. Neurochem Int. pii: S0197-0186(18)30020-2. PMID29772253

Brown R, Benveniste H, Black SE, Charpak S, Dichgans M, Joutel A, Nedergaard M, Smith KJ, Zlokovic BV, Wardlaw JM. (2018) Understanding the role of the perivascular space in cerebral small vessel disease. Cardiovasc Res. 114(11):1462-1473. PMID29726891

Horsburgh K, Wardlaw JM, van Agtmael T, Allan SM, Ashford MLJ, Bath PM, Brown R, Berwick J, Cader MZ, Carare RO, Davis JB, Duncombe J, Farr TD, Fowler JH, Goense J, Granata A, Hall CN, Hainsworth AH, Harvey A, Hawkes CA, Joutel A, Kalaria RN, Kehoe PG, Lawrence CB, Lockhart A, Love S, Macleod MR, Macrae IM, Markus HS, McCabe C, McColl BW, Meakin PJ, Miller A, Nedergaard M, O'Sullivan M, Quinn TJ, Rajani R, Saksida LM, Smith C, Smith KJ, Touyz RM, Trueman RC, Wang T, Williams A, Williams SCR, Work LM. (2018) Small vessels, dementia and chronic diseases- molecular mechanisms and pathophysiology. Clin Sci (Lond). 132(8): 851-868. PMID29712883

Von Holstein-Rathlou S, Petersen NC, Nedergaard M. (2018) Voluntary running enhances glymphatic influx in awake behaving, young mice. Neurosci Lett. 662:253-258. PMC5696653

Plog BA, Nedergaard M. (2018) The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future. Annu Review Pathology.13: 379-394. PMC5803388

Lundgaard I, Wang W, Eberhardt A, Vinitsky HS, Reeves BC, Peng S, Lou N, Hussain R, Nedergaard M. (2018) Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function. Scientific reports. 8(1):2246. PMC5797082

Smith NA, Kress BT, Lu Y, Chandler-Militello D, Benraiss B, Nedergaard M. (2018) Fluorescent Ca2+ indicators directly inhibit the Na, K-ATPase and disrupt cellular functions. Science Signaling. 11(515). PMID29382785

Verkhratsky A, Nedergaard M. (2018) Physiology of Astroglia. Physiolological Reviews. 98(1): 239-389. PMC6050349


Plog BA, Nedergaard M. (2017) The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future. Annual Review of Pathology. [Epub ahead of print] PMID29195051

Holstein-Rathlou S, Petersen NC, Nedergaard M. (2017) Voluntary running enhances glymphatic influx in awake behaving, young mice. Neurosci Letters. 662C: 253-258. PMC5696653

DiNuzzo M, Nedergaard M. (2017) Brain energetics during the sleep-wake cycle. Current Opinion in Neurobiology. 47: 65-72. PMC5732842

Benveniste H, Lee H, Ding F, Sun Q, Al-Bizri E, Makaryus R, Probst S, Nedergaard M, Stein EA, Lu H. (2017) Anesthesia with Dexmedetomidine and Low-dose Isoflurane Increase Solute Transport via the Glymphatic Pathway in Rat Brain When Compared with High-dose Isoflurane. Anesthesiology. 127(6): 976-988. PMC5685871

Louveau H, Plog BA, Antila S, Alitalo K, Nedergaard M, Kipnis J. (2017) Understanding the function of the glymphatic system and meningeal lymphatics. Journal of Clin Invest. 127(9):3210-3219. PMID28862640

Oberheim Bush NA, Nedergaard M. (2017) Do evolutionary changes in astrocytes contribute to the computational power of the hominid brain? Neurochem Res. 42(9): 2577-2587. PMID28822066

Jiang Q, Zhang L, Ding G, Davoodi-Bojd E, Li Q, Li L, Sandry N, Nedergaard M, Chopp M, Zhang Z. (2017) Impairment of the glymphatic system after diabetes. Journal of Cereb Blood Flow Metab 37, 1326-1337. PMC5453454

Mestre H, Kostrikov S, Mehta RI, Nedergaard M. (2017) Perivascular spaces, glymphatic dysfunction, and small vessel disease. Clinical Science. 1-18. PMC5567781

Windrem MS, Osipovitch M, Liu Z, Bates J, Chandler-Militello D, Zou L, Munir J, Schanz S, McCoy K, Miller RH, Wang S, Nedergaard M, Findling RL, Tesar PJ, Goldman SA. (2017) Human iPSC glial mouse chimeras reveal glial contributions to schizophrenia. Cell Stem Cell. 21(2): 195-208. PMC5576346

Lee H, Mortensen K, Sanggaard S, Koch P, Brunner H, Quistorff B, Nedergaard M, Benveniste H. (2017) Quantitative Gd-DOTA uptake from cerebrospinal fluid into rat brain using 3D VFA-SPGR at 9.4T. Magnetic Resonance in Medicine. 79(3): 1568-1578. PMC5736474

Ratner V, Gao Y, Lee H, Elkin R, Nedergaard M, Benveniste H, Tannenbaum A. (2017) Cerebrospinal and Interstitial Fluid Transport via the Glymphatic Pathway Modeled by Optimal Transport. Neuoimage. (152) 530-537. PMC5490081

Achariyar TM, Li B, Peng W, Verghese PB, Shi Y, McConnell E, Benraiss A, Kasper T, Song W, Takano T, Holtzman DM, Nedergaard M, Deane R. (2017) Erratum to: Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation. Molecular Neurodegen. 12(1):3. PMC5234150

Sun W, Cornwell A, Li J, Peng S, Osorio MJ, Wang S, Benraiss A, Lou N, Goldman SA, Nedergaard M. (2017) SOX9 is an astrocyte-specific nuclear marker in the adult brain outside the neurogenic regions. J Neurosci.37(17): 4493-4507. PMC5413187

de Leon MJ, Li Y, Okamura N, Tsui WH, Saint Louis LA, Glodzik L, Osorio RS, Fortea J, Butler T, Pirraglia E, Fossati S, Kim HJ, Carare RO, Nedergaard M, Benveniste H, Rusinek H. (2017) CSF clearance in Alzheimer Disease measured with dynamic PET. J Nucl Med. 58(9):1471-1476 PMC5577629

Kjaerby C, Rasmussen R, Andersen M, Nedergaard M. (2017) Does Global Astrocytic Calcium Signaling Participate in Awake Brain State Transitions and Neuronal Circuit Function? Neurochem Res 42(6): 1810-1822. PMC5451293

Wang M, Nedergaard M, Iliff J. (2017) Focal solute trapping and global glymphatic pathway impairment in a murine model of microinfarcts. J Neurosci. 37(11):2870-2877. PMC5354332


Cotrina ML, Lou N, Tome-Garcia J, Goldman J, Nedergaard M. (2016) Direct comparison of microglial dynamics and inflammatory profile in photothrombotic and arterial occlusion evoked in stroke. Neuroscience. 343:483-494. PMC5523105

Achariyar TM, Li B, Peng W, Verghese PB, Shi Y, McConnell E, Benraiss A, Kasper T, Song W, Takana T, Holtzman DM, Nedergaard M, Deane R. (2016) Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation. Mol Neurodegener. 11(1):74. PMC5146863

Bosetti F, Galis ZS, Charette M, Cipolla MJ, et. al. (2016) “Small Blood Vessels: Big Health Problems?”: Scientific Recommendations of the National Institutes of Health Workshop. J Amer Heart Assoc. 5(11). Pii: e004389. PMC5210346

Xie L, Kang H, Nedergaard M. (2016) A Novel Model of Transient Occlusion of the Middle Cerebral Artery in Awake Mice. J Nat. Sci. 2(2). pii: e176. PMC5074053

Wang F, Wang X, Shapiro LA, Cotrina ML, Liu W, Wang EW, Gu S, Wang W, He X, Nedergaard M, Huang JH. (2016) NKCC1 up-regulation contributes to early post-traumatic seizures and increases post-traumatic seizure susceptibility. Brain Struct Funct 222(3):1543-1556. PMC5368191

Wei HS, Kang H, Rasheed ID, Zhou S, Lou N, Gershteyn A, McConnell ED, Wang Y, Richardson KE, Palmer AF, Xu C, Wan J, Nedergaard M. (2016) Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation. Neuron. 91(4): 851-62. PMC5405863

Lundgaard I, Lon Lu M, Yang E, Peng W, Mestre H, Hitomi E, Deane R, Nedergaard M. (2016) Glymphatic clearance controls state-dependent changes in brain lactate concentration. Journal of Cereb Blood Flow and Metab. 37(6):2112-2124. PMC5464705

Rasmusen R, Nedergaard M, Petersen NC. (2016) Sulforhodamine 101, a widely used astrocyte marker, can induce cortical seizure-like activity at concentrations commonly used. Sci Report. 6:30433. PMC4960645

Verkhratsky A, Nedergaard M. (2016) The homeostatic astroglia emerges from evolutionary specialization of neural cells. Philosophical transactions of the Royal Society of London, Series B, Biological Sciences. 371(1700) PMC4938028

Benraiss A, Wang S, Herrlinger S, Li X, Chandler-Militello D, Mauceri J, Burm H, Toner M, Osipovich M, Xu Q, Ding F, Kang N, Curtin PC, Brunner D, Windrem MS, Munoz-Sanjuan I, Nedergaard M, Goldman SA. (2016) Human glia can both induce and rescue aspects of disease phenotype in Huntington disease. Nature Communications, 7-11758. PMC4899632

Peng W, Achariyar TM, Li B, Liao Y, Mestre H, Hitomi E, Regan S, Kasper T, Peng S, Ding F, Benviniste H, Nedergaard M, Deane R. (2016) Suppression of glymphatic fluid transport in a mouse model of Alzheimer’s disease. Neurobiol Dis. (93)215-25. PMC4980916

Nedergaard M, Goldman SA. (2016) Brain Drain: An internal plumbing system rids the brain of toxic wastes. Sleep is when this cleanup ritual occurs. Scientific American. 44-49. PMC5347443

Ding F, O'Donnell J, Xu Q, Kang N, Goldman N, Nedergaard M. (2016) Changes in the composition of brain interstitial ions control the sleep-wake cycle. Science. 352(6285):550-5. PMC5441687

Lou N, Takano T, Pei Y, Xavier AL, Goldman SA, Nedergaard M. (2016) Purinergic receptor P2RY12-dependent microglial closure of the injured blood-brain barrier. Proc Natl Acad Sci U S A. 113(4): 1074-9. PMC4743790


Ratner V, Zhu L, Kolesov I, Nedergaard M, Benveniste H, Tannenbaum A. (2015) Optimal-mass-transfer-based estimation of glymphatic transport in living brain. Proc SPIE Int. Soc. Opt. Eng. 9413. pii: 94131J. PMC4752194

Kiviniemi V, Wang X, Korhonen V, Keinanen T, Tuovinen T, Autio J, LeVan P, Keilholz S, Zang YF, Hennig J, Nedergaard M. (2015) Ultra-fast magnetic resonance encephalography of physiological brain activity - Glymphatic pulsation mechanisms? J Cereb Blood Flow Metab. 36(6): 1033-45. PMC4908626

Xavier AL, Lima FR, Nedergaard M, Menezes JR. (2015) Ontogeny of CX3CR1-EGFP expressing cells unveil microglia as an integral component of the postnatal subventricular zone. Front Cell Neurosci. 9:37. PMC4330885

Jessen NA, Munk AS, Lundgaard I, Nedergaard M. (2015) The Glymphatic System: A Beginner's Guide. Neurochem Res. 40(12): 2583-99. PMC4636982

Plog BA, Nedergaard M. (2015) Why have we not yet developed a simple blood test for TBI? Expert Rev Neurother. 15(5):465-8. PMID25821902

McConnell ED, Wei HS, Reitz KM, Kang H, Takano T, Vates GE, Nedergaard M. (2015) Cerebral microcirculatory failure after subarachnoid hemorrhage is reversed by hyaluronidase. J Cereb Blood Flow Metab. 36(9): 1537-52. PMC5012515

Makaryus R, Lee H, Feng T, Park JH, Nedergaard M, Jacob Z, Enikolopov G, Benveniste H. (2015) Brain maturation in neonatal rodents is impeded by sevoflurane anesthesia. Anesthesiology. 123(3): 557-68. PMC4543401

Liu X, Wang C, Fujita T, Malmstrom HS, Nedergaard M, Ren YF, Dirksen RT. (2015) External Dentin Stimulation Induces ATP Release in Human Teeth. J Dental Res 94(9) 1259-1266. PMC4547316

Thrane A, Thrane VR, Plog BA, Nedergaard M. (2015) Filtering the muddied waters of brain edema. Trends in Neurosci (38)6. 333-335. PMID26008121

Sreetama SC, Takano T, Nedergaard M, Simon SM, Jaiswal JK. (2015) Injured astrocytes are repaired by Synaptotagmin XI-regulated lysosome exocytosis. Cell Death Differ 1-12. PMC4986631

Xavier RAL, Kress BT, Goldman SA, Menezes L, Nedergaard M. (2015) A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone. J Neurosci 35(34):11848-61. PMC4549398

Iliff JJ, Goldman, SA, and Nedergaard M. (2015) Implications of the discovery of brain lymphatic pathways. Lancet Neurol. 14(10):977-9. PMC4655610

Benveniste H, Hof PR, Nedergaard M, Bechter K. (2015) Modern Cerebrospinal Fluid Flow Research and Heinrich Quincke’s Seminal 1872 Paper on the Distribution of Cinnabar in Freely Moving Animals. J Comp Neurol. 523(12):1748-55. PMC4472498

Lee H, Xie L, Yu M, Kang H, Feng T, Deane R, Logan J, Nedergaard M, and Benveniste H. (2015) The Effect of Body Posture on Brain Glymphatic Transport. J Neurosci 35, 11034-11044. PMC4524974

Lundgaard I, Li B, Xie L, Kang H, Sanggaard S, Haswell JDR, Sun W, Goldman S, Blekot S, Nielsen M, Takano T, Deane R, Nedergaard M. (2015) Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism. Nature Commu. 6:6807. PMC4410436

Plog BA, Dashnaw ML, Hitomi E, Peng W, Liao Y, Lou N, Deane R, Nedergaard M. (2015) Biomarkers of traumatic injury are transported from brain to blood via the glymphatic system. J Neurosci 35(2):518-26. PMC4293408

Fujita T, Chen MJ, Li B, Smith NA, Peng WG, Sun W, Toner MJ, Kress BT, Wang L, Benraiss A, Takano T, Wang S, Nedergaard M. (2015) Neuronal Transgene Expression in Dominant-Negative SNARE Mice. J Neurosci 34(50):16594-604. PMC4261088

Haydon PG, Nedergaard M. (2015) How do astrocytes participate in neural plasticity? Cold Spring Harbor perspectives in biology 7(3): a020438. PMC4355266

Snyder HM, Corriveau RA, Craft S, Nedergaard M. (2015) Vascular contributions to cognitive impairment and dementia including Alzheimer's disease. Alzheimers Dement. 11(6): 710-7. PMC4731036


Xavier AL, Menezes JR, Goldman SA, Nedergaard M. (2014) Fine-tuning the central nervous system: microglial modelling of cells and synapses. Philosophical transactions of the Royal Society of London Series B, Biological sciences 369(1654): 20130593. PMC4173279

Verkhratsky A, Nedergaard M. (2014) Astroglial cradle in the life of the synapse. Philosophical transactions of the Royal Society of London Series B, Biological sciences 369(1654): 20130595. PMC4173281

Tong J, Ren Y, Wang X, Nedergaard M. (2014) Assessment of Nogo-66 receptor 1 function in vivo after spinal cord injury. Neurosurgery 5(1): 51-60. PMC4062593

Thrane AS, Rangroo Thrane V, Nedergaard M. (2014) Drowning stars: reassessing the role of astrocytes in brain edema. Trends in neurosciences 37(11): 620-8. PMC4253572

Takano T, He W, Han X, Nedergaard M. (2014) Rapid manifestation of reactive astrogliosis in acute hippocampal brain slices. Glia 62(1): 78-95. PMC4097059

Plog BA, Moll KM, Kang H, Nedergaard M. (2014) A novel technique for morphometric quantification of subarachnoid hemorrhage-induced microglia activation. Journal of neuroscience methods; 229: 44-52. PMC4077584

Petraglia AL, Plog BA, Dayawansa S, Nedergaard M. (2014) The pathophysiology underlying repetitive mild traumatic brain injury in a novel mouse model of chronic traumatic encephalopathy. Surgical neurology international 5: 184. PMC4287910

Petraglia AL, Plog BA, Dayawansa S, Nedergaard M, Wang J. (2014) The spectrum of neurobehavioral sequelae after repetitive mild traumatic brain injury: a novel mouse model of chronic traumatic encephalopathy. Journal of neurotrauma A novel technique for morphometric quantification of subarachnoid (13): 1211-24. PMC4082360

Larsen BR, Assentoft M, Cotrina ML, Hua SZ, Nedergaard M, Kaila K, Voipio J, Macaulay N. (2014) Contributions of the Na(+) /K(+) - ATPase, NKCC1, and Kir4.1 to hippocampal K(+) clearance and volume responses. Glia 62, 608-22. PMC4302754

Lundgaard I, Osorio MJ, Kress BT, Sanggaard S, Nedergaard M. (2014) White matter astrocytes in health and disease. Neuroscience 276: 161-73. PMC4016995

Kress BT, Iliff JJ, Xia M, Nedergaard M. (2014) Impairment of paravascular clearance pathways in the aging brain. Annals of neurology 76(6): 845-61. PMC4245362

Iliff JJ, Chen MJ, Plog BA, Nedergaard M. (2014) Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury. The Journal of neuroscience : the official journal of the Society for Neuroscience 34(49): 16180-93. PMC4252540

Chen G, Park CK, Xie RG, Berta T, Nedergaard M, Ji RR. (2014) Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice. Brain 137(Pt 8): 2193-209. PMC4107738

Fujita T, Chen MJ, Li B, et al. (2014) Neuronal transgene expression in dominant-negative SNARE mice. J Neuroscience 34(50): 16594-604. PMC4261088

Cotrina ML, Chen M, Han X, Nedergaard M. (2014) Effects of traumatic brain injury on reactive astrogliosis and seizures in mouse models of Alexander disease. Brain research 1582: 211-9. PMC4164594

Fields RD, Araque A, Johansen-Berg H, Nedergaard M. (2014) Glial biology in learning and cognition. The Neuroscientist; 20(5): 426-31. PMC4161624


Iliff JJ, Wang M, Zeppenfeld DM, Venkaraman A, Plog BA, Liao Y, Deane R, Nedergaard M. (2013) Cerebral arterial pulsation drives paravascular cerebrospinal fluid-intestitial exchange in the murine brain. J Neurosci 33(46):18190-9. PMC3866416

Wang F, Smith NA, Xu Q, Goldman S, Peng W, Huang JH, Takano T, Nedergaard M. (2013) Photolysis of caged Ca2+ , but not receptor -mediated Ca2+ signaling triggers astrocytic glutamate release. J Neurosci 33: 17414-12. PMC3812507

Bekar LK, Nedergaard M. (2013) Is potassium a ubiquitous mediator of vasodilation in the central nervous system? Biophys J 105(10):2238-9. PMC3838730

Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Thiyagarajan M, O’Donnell J, Christensen DJ, Nicholson C, Iliff JJ, Takano T, Deane R, Nedergaard M. (2013) Sleep Drives Metabolite Clearance from the Adult Brain. Science 342(6156):373-7. PMC3880190

Ding F, O’Donnell J, Thrane AS, Zeppenfeld Z, Kang H, Xie L, Wang F, Nedergaard M. (2013) α1- adrenergic receptors mediate coordinated Ca2+ signaling of cortical astrocytes in awake, behaving mice. Cell Calcium 54(6):387-94. PMC3858490

Rangroo Thrane V, Thrane AS, Plog BA, Thiyagarajan M, Iliff JJ, Deane R, Nagelhus EA, Nedergaard M. (2013) Paravascular microcirculation facilitates rapid lipid transport and astrocyte signalling in the brain. Sci Rep 3:2582. PMC3761080

Ren Z, Chen X, Yang J, Kress BT, Tong J, Liu H, Takano T, Zhao Y, Nedergaard M. (2013) Improved axonal regeneration after spinal cord injury in mice with conditioned deletion of ephrin B2 under the GFAP promoter. Neuroscience 241:89-99. PMC3892957

Langevin HM, Fujita T, Bouffard NA, Takano T, Koptiuch C, Badger GJ, Nedergaard M. (2013) Fibroblast cytoskeletal remodeling induced by tissue stretch involves ATP signaling.J Cell Physiol 228(9):1922-6. PMC3874839

Goldman N, Chandler-Militello D, Langevin HM, Nedergaard M, Takano T. (2013) Purine receptor mediated actin cytoskeleton remodeling of human fibroblasts. Cell Calcium 53(4):297-301. PMC3601548

Thrane AS, Takano T, Rangroo Thrane V, Wang F, Peng W, Ottersen OP, Nedergaard M, Nagelhus EA. (2013) In vivo NADH fluorescence imaging indicates effect of aquaporin-4 deletion on oxygen microdistribution in cortical spreading depression. J Cereb Blood Flow Metab 33(7):996-9. PMC3705443

Yang L, Kress BT, Weber HJ, Thiyagarajan M, Wang B, Deane R, Benveniste H, Iliff JJ, Nedergaard M. (2013) Evaluating glymphatic pathway function utilizing clinically relevantintrathecal infusion of CSF Tracer. J Transl Med 11(1):107. PMC3665671

Ji RR, Berta T, Nedergaard M. (2013) Glia and pain: Is chronic pain a gliopathy? Pain pii: S0304-3959(13)00330-8. PMC3858488

Nedergaard M. (2013) Neuroscience. Garbage truck of the brain. Science 340(6140):1529-30. PMC3749839

Benraiss A, Toner MJ, Xu Q, Bruel-Jungerman E, Rogers EH, Wang F, Economides AN, Davidson BL, Kageyama R, Nedergaard M, Goldman SA. (2013) Sustained Mobilization of Endogenous Neural Progenitors Delays Disease Progression in a Transgenic Model of Huntington's disease. Cell Stem Cell12(6):787-99. PMC4051319

Han X, Chen M, Wang F, Windrem M, Wang S, Schanz S, Xu Q, Oberheim NA, Bekar L, Betstadt S, Silva AJ, Takano T, Goldman SA, Nedergaard M. (2013) Forebrain Engraftment by Human Glial Progenitor Cells Enhances Synaptic Plasticity and Learning in Adult Mice. Cell Stem Cell 12(3):342-53. PMC3700554

Langevin HM, Nedergaard M; Howe A. (2013) Cellular control of connective tissue matrix tension. J Cell Biochem 114(8):1714-9. PMC3746739

Ren Z, Iliff JJ, Yang L, Yang J, Chen X, Chen MJ, Giese RN, Wang B, Shi X, Nedergaard M. (2013) 'Hit & Run' model of closed-skull traumatic brain injury (TBI) reveals complex patterns of post-traumatic AQP4 dysregulation. J. Cereb Blood Flow Metab 33(6):834-45. PMC3677112

Iliff JJ, Lee H, Yu M, Feng T, Logan J, Nedergaard M, Benveniste H. (2013) Brain-wide paravascular pathway for cerebrospinal-interstitial fluid exchange visualized by contrast enhanced MRI. J Clin Invest 123(3):1299-309. PMC3582150

Iliff JJ, Nedergaard M. (2013) Is there a cerebral lymphatic system? Stroke 44(6 Suppl1):S93-5. PMC3699410

Sun W, McConnell E, Pare JF, Xu Q, Chen M, Lovatt D, Han X, Smith Y, Nedergaard M. (2013) Glutamate-dependent neuroglial calcium signaling differs between young and adult brain. Science 339:197-200. PMC356900

Rangroo Thrane V, Thrane AS, Wang F, Cotrina ML, Smith NA, Chen M, Xu Q, Kang N, Fujita T, Nagelhus EA, Nedergaard M, et al. (2013) Ammonia triggers neuronal disinhibition and seizures by impairing astrocyte potassium buffering. Nature medicine 19, 1643-1648. PMC3899396

Verkhratsky A, Pankratov Y, Lalo U, Nedergaard M. (2012) P2X receptors in neuroglia. Wiley Interdiscip Rev Membr Transp Signal 1(2). PMC3859444

Wang M, Iliff J, Liao Y, Chen MJ, Shinseki M, Venkataraman V, Nedergaard M. (2012) Cognitive deficits and delayed neuronal loss in a mouse model of multiple microinfarcts. J Neurosci 32:17948-60. PMC3541041

Iliff JJ, Nedergaard M. (2012) A link between Glial Ca (2+) signaling and hypoxia in aging? J Cereb Blood Flow Metab 33(2):170. PMC3564207

Bennett MV, Garré JM, Orellana JA, Bukauskas FF, Nedergaard M, Sáez JC. (2012) Connexin and pannexin hemichannels in inflammatory responses of glia and neurons. Brain Res 1487:3-15. PMC3627726

Cotrina ML, Nedergaard M. (2012) Brain connexins in demyelinating diseases: therapeutic potential of glial targets. Brain Res 1487:61-8. PMC3506183

Bekar LK, Wei HS, Nedergaard M. (2012) The locus coeruleus-norepinephrine network optimizes coupling of cerebral blood volume with oxygen demand. J Cereb Blood Flow Metab 32:2135-45. PMC3519408

Takano T, Chen X, Luo F, Fujita T, Ren Z, Goldman N, Zhao Y, Markman JD, Nedergaard M. (2012) Traditional acupuncture triggers a local increase in adenosine in human subjects. J Pain 13:1215-23. PMC3587733

Enger R, Gundersen GA, Haj-Yasein NN, Eilert-Olsen M, Thoren AE, Vindedal GF, Petersen PH, Skare Ø, Nedergaard M, Ottersen OP, Nagelhus EA. (2012) Molecular scaffolds underpinning macroglial polarization: an analysis of retinal Müller cells and brain astrocytes in mouse. Glia 60(12):2018-26. PMC4306326

Thrane AS, Rangroo Thrane V, Zeppenfeld D, Lou N, Xu Q, Nagelhus EA, Nedergaard M. (2012) General anesthesia selectively disrupts astrocyte calcium signaling in the awake mouse cortex. Proc Natl Acad Sci U.S.A. 109:18974-9. PMC3503159

Chen MJ, Kress B, Han X, Moll K, Peng W, Ji RR, Nedergaard M. (2012) Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury. Glia 60:1660-70. PMC3604747

O'Donnell J, Zeppenfeld D, McConnell E, Pena S, Nedergaard M. (2012) Norepinephrine: a neuromodulator that boosts the function of multiple cell types to optimize CNS performance. Neurochem Res 37:2496-512. PMC3548657

Goldman SA, Nedergaard M, Windrem MS. (2012) Glial Progenitor cell-based treatment and modeling of neurological disease. Science 338:491-5. PMC3548656

Rangroo Thrane V, Thrane AS, Chanag J, Alleluia V, Nagelhus EA, Nedergaard M. (2012) Real-time analysis of microglial activation and motility in hepatic and hyperammonemic encephalopathy. Neuroscience 220:247-55. PMC3593111

Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gunderson GA, Benveniste H, Vates GE, Deane R, Goldman SA, Nagelhus EA, Nedergaard M. (2012) A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci Transl Med 4:147ra111. PMC3551275

Nedergaard M, Verkhratsky A. (2012) Artifact versus reality—how astrocytes contribute to synaptic events. Glia 60:1013-23. PMC3340515

Wang F, Xu Q, Wang W, Takano T, Nedergaard M. (2012) Bergmann glia modulate cerebellar Purkinje cell bistability via Ca2+-dependent K+ uptake. Proc Natl Acad Sci U.S.A. 109:7911-6. PMC3356677

Lovatt D, Xu Q, Liu W, Takano T, Smith NA, Schnermann J, Tieu K, Nedergaard M. (2012) Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity. Proc Natl Acad Sci U.S.A. 109:6265-70. PMC3341061

Messing A, Brenner M, Feany MB, Nedergaard M, Goldman JE. (2012) Alexander Disease. J Neurosc 32:5017–5023. PMC3336214

Verkhratsky A, Sofroniew MV, Messing A, DeLanerolle NC, Rempe D, Rodríguez J, Nedergaard M. (2012) Neurological diseases as primary gliopathies: a reassessment of neurocentrism. ANS Neuro 4. PMC3320215

Wang F, Smith NA, Xu Q, Fujita T, Baba A, Matsuda T, Takano T, Bekar L, Nedergaard M. (2012) Astrocytes modulate neural network activity by Ca²+-dependent uptake of extracellular K+. Sci. Signal 5:ra26. PMC3515082

Huang C, Han X, Li X, Lam E, Peng W, Lou N, Torres A, Yang M, Mauricio Garre J, Tian GF, Bennett MV, Nedergaard M, Takano T. (2012) Critical role of connexin 43 in secondary expansion of traumatic spinal cord injury. J. Neurosci 32:3333-8. PMC3569730

Torres A, Xu Q, Wang F, Fujita T, Dobrowski R, Willecke K, Takano T, Nedergaard M. (2012) Extracellular Ca2+ acts as a mediator of communication from neurons to glia. Sci Signal 5:ra8. PMC3548660

Fujita T, Williams EK, Jensen TK, Smith NA, Takano T, Tieu K, Nedergaard M. (2012) Cultured astrocytes do not release adenosine during hypoxic conditions. J Cereb Blood Flow Metab 32:e1-7. PMC3323303

Oberheim NA, Goldman SA, Nedergaard M. (2012) Heterogeneity of astrocytic form and function. Methods Mol Biol 814:23-45. PMC3506190


Christensen DJ, Nedergaard M. (2011) Two-photon in vivo imaging of cells. Pediatric Nephrology 26:1483-9. PMID21404099

Thrane AS, Rappold PM, Fujita T, Torres A, Bekar LK, Takano T, Peng W, Wang F, Thrane VR, Enger R, Haj-Yasein NN, Skare Ø, Holen T, Klungland A, Ottersen OP, Nedergaard M, Nagelhus EA. (2011) Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema. Proc Natl Acad Sci U.S.A. 108:846-51. PMC3021020

Kasischke KA, Labmert EM, Panepento B, Sun A, Gelbard HA, Burgess RW, Foster TH, Nedergaard M. (2011) Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regions. J Cereb Blood Flow Metab 31:68-81. PMC3049466


Hertz L, Lovatt D, Goldman SA, Nedergaard M. (2010) Adrenoceptors in brain: cellular gene expression and effects on astrocytic metabolism and [Ca2+]. Neurochem Int 57:411-20. PMC2934885

Kimelberg HK, Nedergaard M. (2010) Functions of astrocytes and their potential as therapeutic targets. Neurotherapeutics 7:338-353. PMC2982258

Rempe DA, Nedergaard M. (2010) Targeting glia for treatment of neurological disease. Neurotherapeutics 7:335-7. PMC5084296

Kang J, Kang N, Yu Y, Zhang J, Petersen N, Tian GF, Nedergaard M. (2010) Sulforhodamine 101 induces long-term potentiation of intrinsic excitability and synaptic efficacy in hippocampal CA1 pyramidal neurons. Neuroscience 169:1601-9. PMC2918738

Vates GE, Takano T, Zlokovic B, Nedergaard M. (2010) Pericyte constriction after stroke: the jury is still out. Nature Med 16:959. PMID20823870

Goldman N, Chen M, Fujita T, Xu Q, Peng W, Liu W, Jensen TK, Pei Y, Wang F, Han X, Chen JF, Schnermann J, Takano T, Bekar L, Tieu K, Nedergaard M. (2010) Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture. Nat Neurosci 13:883-8. PMC3467968

Zhang S, Li B, Lovatt D, Xu J, Song D, Goldman SA, Nedergaard M, Hertz L, Peng L. (2010) 5-HT2B receptors are expressed on astrocytes from brain and in culture and are a chronic target for all five conventional 'serotonin-specific reuptake inhibitors'. Neuron Glia Biol 6:113-25. PMID20846463

Nedergaard M, Verkhratsky A. (2010) Calcium dyshomeostasis and pathological calcium signaling in neurological diseases. Cell Calcium 47:101-2. PMC3268371


Nedergaard M, Rodriguez JJ, Verkhratsky A. (2009) Glial calcium and diseases of the nervous system. Cell Calcium 47:140-9. PMID20045186

Rempe DA, Takano T, Nedergaard M. (2009) TR(I)Pping towards treatment for ischemia. Nat Neurosci 12:1215-6. PMID19783978

Peng W, Cotrina ML, Han X, Yu H, Bekar L, Blum L, Takano T, Tian GF, Goldman SA, Nedergaard M. (2009) Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury. Proc Natl Acad Sci U.S.A. 106:12489-12493. PMC2718350

Cotrina ML, Nedergaard M. (2009) Physiological and pathological functions of P2X7 receptor in the spinal cord. Purinergic Signal 5:223-32. PMC2686828

Oberheim N, Takano T, Han X, He W, Lin J, Wang F, Xu Q, Wyatt J, Pilcher W, Ojemann JG, Ransom BR, Goldman SA, Nedergaard M. (2009) Uniquely hominid features of adult human astrocytes. J Neuroscience 29:3276-3287. PMC2819812

Takano T, Oberheim N, Cotrina ML, Nedergaard M. (2009) Astrocytes and ischemic injury. Stroke 40:S8-S12. PMC2653262

Hedley-Whyte ET, Goldman JE, Nedergaard M, Friedman A, Han X, Schmidt RE, Powers JM. (2009) Hyaline protoplasmic astrocytopathy of neocortex. J Neuropathol Exp Neurol 68:136-147. PMID19151628

Takano T, Nedergaard M. (2009) Deciphering migraine. J Clin Invest 119:16-19. PMC2613455

Wang X, Takano T, Nedergaard M. (2009) Astrocytic calcium signaling: mechanism and implications for functional brain imaging. Methods Mol Biol 489:93-109. PMC3638986


Bekar LK, He W, Nedergaard M. (2008) Locus coeruleus α-adrenergic-mediated activation of cortical astrocytes in vivo. Cerebral Cortex 18:2789-95. PMC2583159

Cotrina ML, Lin JH, Nedergaard M. (2008) Adhesive properties of Connexin hemichannels. Glia 56: 1791-8. PMC2577568

Windrem MS, Schanz SJ, Guo M, Tian GF, Washco V, Stanwood N, Rasband M, Roy NS, Nedergaard M, Havton LA, Wang S, Goldman SA. (2008) Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse. Cell Stem Cell 2:553-65. PMC3358921

Xu H, Hu F, Sado Y, Ninomiya Y, Borza DB, Ungvari Z, Lagamma EF, Csiszar A, Nedergaard M, Ballabh P. (2008) Maturational changes in laminin, fibronectin, collagen IV, and perlecan in germinal matrix, cortex, and white matter and effect of betamethasone. J Neurosci Res 86:1482-500. PMID18214989

Kang J, Kang N, Lovatt D, Torres A, Zhao Z, Lin J, Nedergaard M. (2008) Connexin 43 hemichannels are permeable to ATP J Neurosci 28:4701-11. PMC3638995

Oberheim NA, Tian GT, Han X, Peng W, Takano T, Ransom B, Nedergaard M. (2008) Loss of astrocytic domain organization in the epileptic brain. J Neurosci 28:3264-76. PMID18367594

Lin JH, Lou N, Kang N, Takano T, Hu F, Han X, Xu Q, Lovatt D, Torres A, Willecke K, Yang J, Kang J, Nedergaard M. (2008) A central role of connexin 43 in hypoxic preconditioning. J Neurosci 28:681-695. PMID18199768

Neuwelt E, Abbott NJ, Abrey L, Banks WA, Blakley B, Davis T, Engelhardt B, Grammas P, Nedergaard M, Nutt J, Pardridge W, Rosenberg GA, Smith Q, Drewes LR. (2008) Strategies to advance translational research into brain barriers. Lancet Neurol 7:84-96. PMID18093565

Bekar L, Libionka W, Tian GF, Xu Q, Torres A, Wang X, Lovatt D, Williams E, Takano T, Schnermann J, Bakos R, Nedergaard M. (2008) Adenosine is crucial for deep brain stimulation-mediated attenuation of tremor. Nat Med 14:75-80. PMID18157140


Lovatt D, Sonnewald U, Waagepetersen HS, Schousboe A, He W, Lin JHC, Han X, Takano T, Wang S, Sim F, Goldman SA, Nedergaard M. (2007) The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex. J Neurosci 27:12255-66. PMID17989291

Iadecola C, Nedergaard M. (2007) Glial regulation of the cerebral microvasculature. Nat Neurosci 10:1369-76. PMID17965657

Braun A, Xu H, Hu F, Kockherlakota P, Siegel D, Chander P, Ungvari Z, Csiszar A, Nedergaard M, Ballabh P. (2007) Paucity of pericytes in germinal matrix vasculature of premature infants. J Neurosci 27:12012-24. PMID17978043

Jaiswal JK, Fix M, Takano T, Nedergaard M, Simon SM. (2007) Resolving vesicle fushion from lysis to monitor calcium-triggered lysosomal exocytosis in astrocytes. Proc Natl Acad Sci U.S.A. 104:14151-6. PMC1955787

Takano T, Tian GF, Han X, Peng W, Lou N, Lovatt D, Hansen A, Kasischke K, Nedergaard M. (2007) Cortical spreading depression causes and coincides with tissue hypoxia. Nat Neurosci 10:754-62. PMID17468748

Takano T, Nedergaard M. (2007) DM-nitrophen provides physiologically significant increases of intracellular [Ca2+] in the presence of Mg2+. Cell Calcium 41:503-4. PMID17055047

Ballabh P, Xu H, Braun A, Smith K, Rivera A, Lou N, Ungvari Z, Goldman SA, Csiszar A, Nedergaard M. (2007) Angiogenic inhibition reduces germinal matrix hemorrhage. Nat Med 13:477-85. PMID17401377

Takano T, Han X, Deane R, Zlokovic B, Nedergaard M. (2007) Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer’s disease. Ann N Y Acad Sci 1097:40-50. PMID17413008

Lin JH-C, Takano T, Arcuino G, Wang X, Hu F, Darzynkiewicz Z, Nunes M, Goldman SA, Nedergaard M. (2007) Purinergic signaling regulates neural progenitor cell expansion and neurogenesis. Dev Biology 302:356-66. PMC1924912


Oberheim NA, Wang X, Goldman SA, Nedergaard M. (2006) Astrocytic complexity distinguishes the human brain. Trends Neurosci 29:547-53. PMID16938356

Tian GF, Takano T, Wang X, Lin JH, Bekar L, Nedergaard M. (2006)Imaging of cortical astrocytes using 2-photon laser scanning microscopy in the intact mouse brain.  Advanced Drug Delivery 58:773-87. PMID170445697

Wang X, Lou N, Xu Q, Tian GF, Peng WG, Han X, Takano T, Nedergaard M. (2006) Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo. Nat. Neurosci 9:816-823. PMID16699507

El-Khoury N, Braun A, Hu F, Pandey M, Nedergaard M, Lagamma EF, Ballabh P. (2006) Astrocyte end-feet in germinal matrix, cerebral cortex, and white matter in developing infants. Pediatr Res 59:673-679. PMID16627880

Anderson CM, Nedergaard M. (2006) Emerging challenges of assigning P2X7 receptor function and immunoreactivity in neurons. Trends Neurosci 29:257-62. PMID16564580

Takano T, Tian GF, Peng W, Lou N, Libionka W, Han X, Nedergaard M. (2006) Astrocyte-mediated control of cerebral blood flow. Nat Neurosci 9:260-267. PMID16388306


Singh Roy N, Takano T, Xuing L, Kang J, Nedergaard M, Goldman SA. (2005) Enhancer-specified GFP-based FACS purification of human spinal motor neurons from embryonic stem cells. Exp Neurol 196:224-234. PMID16198339

Kang N, Xu J, Xu Q. Nedergaard M, Kang J. (2005) Astrocytic glutamate release-induced transient depolarization and epileptiform discharges in hippocampal CA1 pyramidal neurons. J Neurophysiol 94:4121-4130. PMID16162834

Takano T, Kang J, Jaiswal JK, Simon SM, Lin JH, Yu Y, Li Y, Yang J, Dienel G, Zielke HR, Nedergaard M. (2005) Receptor-mediated glutamate release from volume sensitive channels in astrocytes. Proc Natl Acad Sci U.S.A. 102:16466-16471. PMC1283436

Ballabh P, Hu F, Kumarasiri M, Braun A, Nedergaard M. (2005) Development of tight junction molecules in blood vessels of germinal matrix, cerebral cortex, and white matter. Pediatr Res 58:791-798. PMID16189211

Tian GF, Azmi H, Takano T, Xu Q, Peng W, Lin J, Oberheim N, Lou N, Zielke HR, Kang J, Nedergaard M. (2005) An astrocytic basis of epilepsy. Nat Med 11:973-981. PMC1850946

Nedergaard M, Dirnagl U. (2005) Role of glial cells in cerebral ischemia. Glia 50:281-286. PMID15846807

Xu J, Kang N, Jiang L, Nedergaard M, Kang J. (2005) Activity-dependent long-term potentiation of intrinsic excitability in hippocampal CA1 pyramidal neurons. J Neurosci 25:1750-1760. PMID15716411

Liu QS, Xu Q, Kang J, Nedergaard M. (2005) Astrocyte activation of metabotropic glutamate receptors modulates hippocampal inhibitory synaptic transmission. Neuron Glia Biology 1:307-316. PMC1474019


Kang N, Jiang L, He W, Xu J, Nedergaard M, Kang J. (2004) Presynaptic inactivation of action potentials and postsynaptic inhibition of GABAA currents contribute to KA-induced disinhibition in CA1 pyramidal neurons. J Neurophysiol 92:873-82. PMID14999044

Wang X, Arcuino G, Takano T, Lin J, Peng WG, Wan P, Li P, Xu Q, Liu QS, Goldman SA, Nedergaard M. (2004) P2X7 receptor inhibition improves recovery after spinal cord injury. Nat Med 10:821-7. PMID15258577

Ballabh P, Braun A, Nedergaard M. (2004) Anatomic analysis of blood vessels in germinal matrix, cerebral cortex, and white matter in developing infants. Pediatric Res 56:117-24. PMID15128918

Ballabh P, Braun A, Nedergaard M. (2004) The blood-brain barrier: an overview, structure, regulation, and clinical implications. Neurobiol Dis 16:1-13. PMID15207256

Liu QS, Xu Q, Arcuino G, Kang J, Nedergaard M. (2004) Astrocyte-mediated activation of neuronal kainate receptors. Proc Natl Acad Sci U.S.A. 101:3172-7. PMC365762

Roy NS, Takano T, Keyoung HM, Windrem M, Rashbaum WK, Alonso ML, Kang J, Peng W, Carpenter MK, Lin J, Nedergaard M, Goldman SA. (2004) Telomerase immortalization of neuronally restricted progenitor cells derived from the human fetal spinal cord. Nat Biotechnol 22:297-305. PMID14990951

Simard M, Nedergaard M. (2004) The neurobiology of glia in the context of water and ion homeostasis. Neuroscience 129:877-96. PMID15561405


Simard M, Arcuino GA, Takano T, Liu Q-S, Nedergaard M. (2003) Signaling at the gliovascular interface. J Neurosci 23:9254-9262. PMID14534260

Nedergaard M, Ransom B, Goldman SA. (2003) New roles for astrocytes: Redefining the functional architecture of the brain. Trends Neurosci 26:523-530. PMID14522144

Ransom B, Behar T, Nedergaard M. (2003) New roles for astrocytes (stars at last). Trends Neurosci 26:520-522. PMID14522143

Anderson C, Nedergaard M. (2003) Astrocyte-mediated control of cerebral microcirculation. Trends Neurosci 26:340-344. PMID12850427

Nunes MC, Roy NS, Keyoung HM, Goodman RR, McKhann G II, Jiang L, Kang J, Nedergaard M, Goldman SA. (2003) Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain. Nat Med 9:439-447. PMID12627226

Lin JH-C, Yang J, Gao Q, Takano T, Wang X, Willecke K, Nedergaard M. (2003) Connexin mediates gap injuction-independent resistance to cellular injury. J Neurosci 23:430-441. PMID12533603


Nedergaard M, Takano T, Hansen AJ. (2002) Beyond the role of glutamate as a neurotransmitter. Nat Rev Neurosci 3:748-755. PMID12209123

Goldman SA, Nedergaard M. (2002) Erythropoitin strikes a new cord. Nat Med 8:785-7. PMID12152030

Arcuino G, Lin JH, Takano T, Liu C, Jiang L, Gao Q, Kang J, Nedergaard M. (2002) Intercellular calcium signaling mediated by point source burst release of ATP. Proc Natl Acad Sci 99:9840-9845. PMC125036

Lin JH, Takano T, Cotrina ML, Arcuino G, Kang J, Liu S, Gao Q, Jiang L, Li F, Lichtenberg-Frate H, Haubrich S, Willecke K, Goldman SA, Nedergaard M. (2002) Connexin 43 mediates the adhesivity and invasiveness of malignant glioma cells. J. Neurosci 22:4302-11. PMID12040035

Cotrina ML, Nedergaard M. (2002) Astrocytes in the aging brain. J. Neurosci Res 67:1-10. PMID11754075


Takano T, Lin JH, Arcuino G, Gao Q, Yang J, Nedergaard M. (2001) Glutamate release promotes growth of malignant gliomas. Nature Medicine 7:1010-1015. PMID11533703

Cotrina ML, Gao Q, Lin J, Nedergaard M. (2001) Expression and function of astrocytic gap junctions in aging. Brain Res 901:55-61. PMID11368950

Jiang L, Xu J, Nedergaard M, Kang J. (2001) A kainate receptor increases the efficacy of GABAergic synapses. Neuron 30:503-513. PMID11395010


Zhang W, Couldwell WT, Song H, Takano T, Lin JH, Nedergaard M. (2000) Tamoxifen-induced enhancement of calcium signaling in glioma and MCF-7 breast cancer cells. Cancer Res 60:5395-5400. PMID11034078

Cotrina M, Nedergaard M. (2000) ATP as a messenger in astrocyte-neuronal communication. The Neuroscientist 6:120-126.

Cotrina ML, Lin J H, López-García JC, Naus CC, Nedergaard M. (2000) ATP-mediated glia signaling. J. Neurosci 20:2835-44. PMID10751435

Martins-Ferreira H, Nedergaard M, Nicholson C. (2000) Perspectives on spreading depression. Brain research. Brain Res Reviews 32:215-34. PMID10751672

Jiang L, Sun S, Nedergaard M, Kang J. (2000) Paired-pulse modulation at individual GABAergic synapses in rat hippocampus. J Physiol 523 Pt 2: 425-439. PMC2269802

Roy NS, Wang S, Jiang L, Kang J, Benraiss A, Harrison-Restelli C, Fraser RA, Couldwell WT, Kawaguchi A, Okano H, Nedergaard M, Goldman SA. (2000) In vitro neurogenesis byisolated from the adult human hippocampus. Nature Medicine 6:271-277. PMID10700228

Roy NS, Benraiss A, Wang S, Fraser RA, Goodman R, Couldwell WT, Nedergaard M, Kawaguchi A, Okano H, Goldman SA. (2000) Promoter-targeted selection and isolation of neural progenitor cells from the adult human ventricular zone. J Neurosci Res 59:321-331. PMID10679767

Grafstein B, Liu S, Cotrina M, Goldman SA, Nedergaard M. (2000) Meningeal cells can communicate with astrocytes by calcium signaling. Ann Neurol 47:18-25.


Simard M, Couldwell WT, Zhang W, Song H, Liu S, Cotrina ML, Goldman SA, Nedergaard M. (1999) Glucocorticoids - potent modulators of astrocytic signaling. Glia 28:1-12.

Zhang W, Couldwell WT, Simard MF, Song H, Lin JH-C, Nedergaard M. (1999) Direct gap junction communication between malignant glioma cells and astrocytes. Cancer Res 59. PMID10213512

Williams S, Leventhal C, Lemmon V, Nedergaard M, Goldman SA. (1999) Estrogen promotes the initial migration and inception of NgCAM-dependent calcium-signaling by new neurons of the adult songbird brain. Molec Cell Neurosci 13:41-55. PMID10049530


Cotrina ML, Lin JH, Alves-Rodrigues A, Liu S, Li J, Azmi-Ghadimi H, Kang J, Naus CCG, Nedergaard M. (1998) Connexins regulate calcium signaling by controlling of ATP release. Proc Natl Acad Sci USA. 95:15735-15740. PMC28113

Kang J, Jiang L, Goldman SA, Nedergaard M. (1998) Astrocyte-mediated potentiation of inhibitory synaptic transmission. Nature Neurosci 1:683-692. PMID10196584

Cotrina ML, Lin JHC, Nedergaard M. (1998) Cytoskeletal assembly and ATP release regulate astrocytic calcium signaling. J. Neurosci 18:8794-8804. PMID9786986

Lin JHC, Weigel W, Cotrina ML, Liu S, Bueno E, Hansen AJ, Hansen TW, Goldman S, Nedergaard M. (1998) Gap junction-mediated propagation and amplification of cell injury. Nature Neurosci 1:494-500. PMID10196547

Pincus DW, Goodman RR, Fraser RA, Nedergaard M, Goldman SA. (1998) Neural stem and progenitor cells: a strategy for gene therapy and brain repair. Neurosurgery 42:858-867.

Cotrina ML, Kang J, Lin H-C, Bueno E, Hansen TW, He L, Liu Y, Nedergaard M. (1998) Astrocytic gap junctions remain open during ischemic conditions. J. Neurosci 18:2520-2537. PMID9502812

Pincus DW, Keyoung HM, Harrison-Restelli C, Goodman R, Fraser RA, Edgar M, Sakakibara S, Okano H, Nedergaard M, Goldman SA. (1998) Fibroblast growth factor-2/brain-derived neurotrophic factor-associated maturation of new neurons generated from adult human subependymal cells. Ann Neurol 42:576-585.


Goldman SA, Nedergaard M, Crystal RG, Fraser RA, Goodman R, Harrison-Restelli C, Jiang J, Keyoung HM, Leventhal C, Pincus DW, Shahar A, Wang S. (1997) Neural precursors and neuronal production in the adult mammalian forebrain. Annals of the New York Academy of Sciences 835:30-55. PMID9616760

Rawanduzy A, Hansen A, Hansen TW, Nedergaard M. (1997) Effective reduction of infarct volume by gap junction blockade in a rodent model of stroke. J. Neurosurg 87:916-920. PMID9384404

Wang Z, Tymianski M, Nedergaard M. (1997) Impact of cytoplasmic calcium buffering on the spatial and temporal characteristics of intercellular calcium signals in astrocytes. J. Neurosci 17:7359-7371. PMID9295382

Rawanduzy A, Hansen A, Hansen TW, Nedergaard M. (1997) Effective reduction of infarct volume by gap junction blockade in a rodent model of stroke. Neurosurgical Focus 2:E1; discussion 1 p following E1. PMID9384404

Pincus DW, Harrison-Restelli C, Barry J, Goodman RR, Fraser RA, Nedergaard M, Goldman SA. (1997) In vitro neurogenesis by adult human epileptic temporal neocortex. Clinical neurosurgery 44:17-25.


Nedergaard M. (1996) Spreading depression as a contributor to ischemic brain damage. Adv Neurol 71:75-83; discussion 83-4.

Goldman SA, Williams S, Barami K, Lemmon V, Nedergaard M. (1996) Transient coupling of Ng-CAM expression to calcium-signaling Ng CAM-dependent calcium signaling during migration of new neurons in the adult songbird. Mol. Cell Neurosci 7:29-45. PMID8812057


Nedergaard M, Cooper AJL, Goldman SA. (1995) Gap junctions are required for the propagation of spreading depression. J. Neurobiol 28:433-444.

Nedergaard M. (1995) Intracellular Ca2+ transients evoked by lactic acid in cultured mammalian neurons. Am. J. Physiol 268:R506-513. PMID7864248


Kirschenbaum B, Nedergaard M, Bahramian K, Fraser R, Preuss A, Goldman SA. (1994) In vitro neuronal production and differentiation by precursor cells derived from the adult human forebrain. Cerebral Cortex 4:576-589.

Makar TK, Nedergaard M, Preuss A, Hertz L, Cooper A. (1994) Glutamine transaminase K and omega-amidase activities in primary cultures of astrocytes and neurons and in embryonic chick forebrain: marked induction of brain glutamine transaminase K at time of hatching. J Neurochem 62. PMID8158144

Nedergaard M. (1994) Direct signaling from astrocytes to neurons in cultures of mammalian brain cells. Science 263:1768-1771. PMID8134839

Makar TK, Nedergaard M, Preuss A, Gelbard S, Cooper A. (1994) Vitamin E, ascorbate, glutathione, glutathione disulfide, and enzymes of glutathione metabolism in cultures of chick astrocytes and neurons: evidence that astrocytes play an important role in antioxidative processes in the brain. J. Neurochem 62:45-53. PMID7903354


Nedergaard M, Goldman SA. (1993) Carrier-mediated transport of lactic acid in cultured neurons and astrocytes. Am. J. Physiol 265:R282-R289. PMID8368382

Nedergaard M, Hansen AJ. (1993) Characterization of cortical depolarizations evoked in focal cerebral ischemia. J. Cereb. Blood Flow Metab 13:568-574. PMID8314912


Goldman SA, Nedergaard M. (1992) Newly generated neurons of the adult songbird brain become functionally active in long-term culture. Dev. Brain Res 68:217-223.


Nedergaard M, Goldman SA, Desai S, Pulsinelli WA. (1991) Acid-induced death in neurons and glia. J. Neurosci 11:2489-2497. PMID1869926

Nedergaard M, Kraig RP, Tanabe J, Pulsinelli WA. (1991) Dynamics of interstitial and intracellular pH in the evolving brain infarct. Am. J. Phys 260:R581-R588. PMC30622631


Nedergaard M, Desai S, Pulsinelli W. (1990) Dicarboxy dichlorofluorescein: a new fluorescent probe for measuring acidic intracellular pH. Anal. Biochem 187:109-114. PMID2372106

Jakobsen J, Nedergaard M, Aarslew-Jensen M, Diemer NH. (1990) Regional brain glucose metabolism and blood flow in streptozotozin-induced diabetic rats. Diabetes 39:437-440. PMID2318347


Nedergaard M, Diemer NH. (1988) Experimental cerebral ischemia: barbiturate resistant increase in regional glucose utilization. J. Cereb. Blood Flow Metab 8:763-766. PMID3417802

Hansen AJ, Nedergaard M. (1988) Brain ion homeostasis in cerebral ischemia. Neurochemical Pathology 9:195-209.

Nedergaard M, Hansen AJ. (1988) Spreading depression is not associated with neuronal injury in the normal rat brain. Brain Research 449:395-398.

Sillesen H, Nedergaard M, Schroeder T, Buchardt Hansen HJ. (1988) Middle cerebral artery occlusion in presence of low perfusion pressure increases infarct size in rats. Neurological Res. 10:61-63.

Nedergaard M. (1988) Mechanisms of brain damage in focal cerebral ischemia. Acta Neurol. Scand 77:81-101. PMID3284272

Nedergaard M, Jakobsen J, Diemer NH. (1988) Autoradiographic determination of cerebral glucose content, blood flow, and glucose utilization, in focal ischemia of the rat brain: influence of the plasma glucose concentration. J. Cereb. Blood Flow Metab 8:100-108. PMID3339100


Nedergaard M, Gjedde A, Diemer NH. (1987) Hyperglycaemia protects against neuronal injury around experimental brain infarcts. Neurological Res 9:241-244.

Nedergaard M. (1987) Transient focal ischemia in hyperglycemic rats is associated with increased cerebral infarction. Brain Res 408:79-85. PMID3594232

Nedergaard M. (1987) Neuronal injury in the infarct border: a neuropathological study in the rat. Acta Neuropathol 73:267-274.

Nedergaard M, Diemer NH. (1987) Focal ischemia of the rat brain, with special reference to the influence of the plasma glucose concentration. Acta Neuropath 73:131-137.


Nedergaard M, Vorstrup S, Astrup J. (1986) Cell density in the border zone around old small human brain infarcts. Stroke 17:1129-1137. PMID3810711

Nedergaard M, Astrup J. (1986) Infarct rim: effect of hyperglycemia on direct current potential and [14C] 2-deoxyglucose phosphorylation. J. Cereb. Blood Flow Metab 6:607-615. PMID3760045

Nedergaard M, Gjedde A, Diemer NH. (1986) Focal ischemia of the rat brain: autoradiographic determination of cerebral glucose utilization, glucose content, and blood flow. J. Cereb. Blood Flow Metab 6:414-424. PMID3733901


Nedergaard M, Astrup J, Klinken L. (1984) Cell density and cortex thickness in the border zone surrounding old infarcts in the human brain. Stroke 15:1033-1039. PMID6209831


Nedergaard M, Klinken L, Paulson OB. (1983) Secondary brain stem hemorrhage in stroke. Stroke 14:501-505.

Nedergaard M, Egeberg J, Kromann H. (1983) Irradiation protects against pancreatic islet degeneration and hyperglycaemia following streptozocin treatment of mice. Diabetologia 24:382-386.


Kromann H, Cristy M, Lernmark A, Nedergaard M, Nerup J. (1982) The low dose streptozotozin murine model of type 1 (insulin dependent) diabetes mellitus: studies in vivo and in vitro of the modulating effect of sex hormones. Diabetologia 22:194-198.