Validation of ultrasonography for measurement of cartilage thickness in the equine carpus
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Validation of ultrasonography for measurement of cartilage thickness in the equine carpus. / Andersen, Camilla; Griffin, John F.; Jacobsen, Stine; Østergaard, Stine; Walters, Marie; Mori, Yuki; Lindegaard, Casper.
In: Veterinary Radiology & Ultrasound, Vol. 63, No. 4, 2022, p. 478-489.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Validation of ultrasonography for measurement of cartilage thickness in the equine carpus
AU - Andersen, Camilla
AU - Griffin, John F.
AU - Jacobsen, Stine
AU - Østergaard, Stine
AU - Walters, Marie
AU - Mori, Yuki
AU - Lindegaard, Casper
PY - 2022
Y1 - 2022
N2 - Articular cartilage thinning is an important hallmark of osteoarthritis (OA), and ultrasonography (US) is a clinically accessible tool potentially suitable for repeated evaluation. The aim of the present prospective methods comparison study was to validate US as a tool for measuring cartilage thickness in the carpus of the horse. Eight Standardbred trotters underwent US examination with 9 and 15 MHz linear transducers. Six anatomical locations in the radiocarpal joint (RCJ) and middle carpal joint (MCJ) were examined. The same joints were assessed by ultrahigh field (9.4 Tesla) magnetic resonance imaging (MRI) and histology. Associations between measurements obtained by the different modalities were assessed by ANOVA, Deming regression, Pearson correlation and Bland-Altman plots. Histologically assessed total cartilage thickness (the noncalcified cartilage (NCC) plus the calcified cartilage zone (CCZ)) overestimated thickness compared to MRI (P < 0.01) and US (P < 0.01). US 15 MHz had substantial agreement with MRI and NCC histology, and repeatability was acceptable (coefficient of variation = 8.6-17.9%) when used for assessment of cartilage thickness in the RCJ. In contrast, 9 MHz US showed poorer agreement with MRI and NCC histology, as it overestimated the thickness of thin cartilage and underestimated the thickness of thicker cartilage in the RCJ and MCJ. Moreover, repeatability was suboptimal (coefficient of variation = 10.4-26.3%). A 15 MHz transducer US is recommended for detecting changes in RCJ cartilage thickness or monitoring development over time, and it has the potential for noninvasive assessment of cartilage health in horses.
AB - Articular cartilage thinning is an important hallmark of osteoarthritis (OA), and ultrasonography (US) is a clinically accessible tool potentially suitable for repeated evaluation. The aim of the present prospective methods comparison study was to validate US as a tool for measuring cartilage thickness in the carpus of the horse. Eight Standardbred trotters underwent US examination with 9 and 15 MHz linear transducers. Six anatomical locations in the radiocarpal joint (RCJ) and middle carpal joint (MCJ) were examined. The same joints were assessed by ultrahigh field (9.4 Tesla) magnetic resonance imaging (MRI) and histology. Associations between measurements obtained by the different modalities were assessed by ANOVA, Deming regression, Pearson correlation and Bland-Altman plots. Histologically assessed total cartilage thickness (the noncalcified cartilage (NCC) plus the calcified cartilage zone (CCZ)) overestimated thickness compared to MRI (P < 0.01) and US (P < 0.01). US 15 MHz had substantial agreement with MRI and NCC histology, and repeatability was acceptable (coefficient of variation = 8.6-17.9%) when used for assessment of cartilage thickness in the RCJ. In contrast, 9 MHz US showed poorer agreement with MRI and NCC histology, as it overestimated the thickness of thin cartilage and underestimated the thickness of thicker cartilage in the RCJ and MCJ. Moreover, repeatability was suboptimal (coefficient of variation = 10.4-26.3%). A 15 MHz transducer US is recommended for detecting changes in RCJ cartilage thickness or monitoring development over time, and it has the potential for noninvasive assessment of cartilage health in horses.
KW - front knee
KW - histopathology
KW - horse
KW - orthopedic
KW - ultrasound
KW - ARTICULAR-CARTILAGE
KW - ULTRASOUND
KW - OSTEOARTHRITIS
KW - DAMAGE
U2 - 10.1111/vru.13085
DO - 10.1111/vru.13085
M3 - Journal article
C2 - 35347811
VL - 63
SP - 478
EP - 489
JO - Veterinary Radiology
JF - Veterinary Radiology
SN - 1058-8183
IS - 4
ER -
ID: 302199061