Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease

Research output: Contribution to journal › Review › Research › peer-review

Standard

Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease. / Khakh, Baljit S.; Beaumont, Vahri; Cachope, Roger; Munoz-Sanjuan, Ignacio; Goldman, Steven A.; Grantyn, Rosemarie.

In: Trends in Neurosciences, Vol. 40, No. 7, 07.2017, p. 422-437.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Khakh, BS, Beaumont, V, Cachope, R, Munoz-Sanjuan, I, Goldman, SA & Grantyn, R 2017, 'Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease', Trends in Neurosciences, vol. 40, no. 7, pp. 422-437. https://doi.org/10.1016/j.tins.2017.05.002

APA

Khakh, B. S., Beaumont, V., Cachope, R., Munoz-Sanjuan, I., Goldman, S. A., & Grantyn, R. (2017). Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease. Trends in Neurosciences, 40(7), 422-437. https://doi.org/10.1016/j.tins.2017.05.002

Vancouver

Khakh BS, Beaumont V, Cachope R, Munoz-Sanjuan I, Goldman SA, Grantyn R. Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease. Trends in Neurosciences. 2017 Jul;40(7):422-437. https://doi.org/10.1016/j.tins.2017.05.002

Author

Khakh, Baljit S. ; Beaumont, Vahri ; Cachope, Roger ; Munoz-Sanjuan, Ignacio ; Goldman, Steven A. ; Grantyn, Rosemarie. / Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease. In: Trends in Neurosciences. 2017 ; Vol. 40, No. 7. pp. 422-437.

Bibtex

@article{9ce9cd8d513242d58967d10aa5214d74,
title = "Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease",
abstract = "Astrocytes are abundant within mature neural circuits and are involved in brain disorders. Here, we summarize our current understanding of astrocytes and Huntington's disease (HD), with a focus on correlative and causative dysfunctions of ion homeostasis, calcium signaling, and neurotransmitter clearance, as well as on the use of transplanted astrocytes to produce therapeutic benefit in mouse models of HD. Overall, the data suggest that astrocyte dysfunction is an important contributor to the onset and progression of some HD symptoms in mice. Additional exploration of astrocytes in HD mouse models and humans is needed and may provide new therapeutic opportunities to explore in conjunction with neuronal rescue and repair strategies.",
keywords = "Journal Article, Review",
author = "Khakh, {Baljit S.} and Vahri Beaumont and Roger Cachope and Ignacio Munoz-Sanjuan and Goldman, {Steven A.} and Rosemarie Grantyn",
note = "Copyright {\textcopyright} 2017 Elsevier Ltd. All rights reserved.",
year = "2017",
month = jul,
doi = "10.1016/j.tins.2017.05.002",
language = "English",
volume = "40",
pages = "422--437",
journal = "Trends in Neurosciences",
issn = "0378-5912",
publisher = "Elsevier Ltd. * Trends Journals",
number = "7",

}

RIS

TY - JOUR

T1 - Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease

AU - Khakh, Baljit S.

AU - Beaumont, Vahri

AU - Cachope, Roger

AU - Munoz-Sanjuan, Ignacio

AU - Goldman, Steven A.

AU - Grantyn, Rosemarie

N1 - Copyright © 2017 Elsevier Ltd. All rights reserved.

PY - 2017/7

Y1 - 2017/7

N2 - Astrocytes are abundant within mature neural circuits and are involved in brain disorders. Here, we summarize our current understanding of astrocytes and Huntington's disease (HD), with a focus on correlative and causative dysfunctions of ion homeostasis, calcium signaling, and neurotransmitter clearance, as well as on the use of transplanted astrocytes to produce therapeutic benefit in mouse models of HD. Overall, the data suggest that astrocyte dysfunction is an important contributor to the onset and progression of some HD symptoms in mice. Additional exploration of astrocytes in HD mouse models and humans is needed and may provide new therapeutic opportunities to explore in conjunction with neuronal rescue and repair strategies.

AB - Astrocytes are abundant within mature neural circuits and are involved in brain disorders. Here, we summarize our current understanding of astrocytes and Huntington's disease (HD), with a focus on correlative and causative dysfunctions of ion homeostasis, calcium signaling, and neurotransmitter clearance, as well as on the use of transplanted astrocytes to produce therapeutic benefit in mouse models of HD. Overall, the data suggest that astrocyte dysfunction is an important contributor to the onset and progression of some HD symptoms in mice. Additional exploration of astrocytes in HD mouse models and humans is needed and may provide new therapeutic opportunities to explore in conjunction with neuronal rescue and repair strategies.

KW - Journal Article

KW - Review

U2 - 10.1016/j.tins.2017.05.002

DO - 10.1016/j.tins.2017.05.002

M3 - Review

C2 - 28578789

VL - 40

SP - 422

EP - 437

JO - Trends in Neurosciences

JF - Trends in Neurosciences

SN - 0378-5912

IS - 7

ER -

ID: 185946358