The homeostatic astroglia emerges from evolutionary specialization of neural cells

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The homeostatic astroglia emerges from evolutionary specialization of neural cells. / Verkhratsky, Alexei; Nedergaard, Maiken.

In: Royal Society of London. Philosophical Transactions B. Biological Sciences, Vol. 371, No. 1700, 20150428, 05.08.2016, p. 1-11.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Verkhratsky, A & Nedergaard, M 2016, 'The homeostatic astroglia emerges from evolutionary specialization of neural cells', Royal Society of London. Philosophical Transactions B. Biological Sciences, vol. 371, no. 1700, 20150428, pp. 1-11. https://doi.org/10.1098/rstb.2015.0428

APA

Verkhratsky, A., & Nedergaard, M. (2016). The homeostatic astroglia emerges from evolutionary specialization of neural cells. Royal Society of London. Philosophical Transactions B. Biological Sciences, 371(1700), 1-11. [20150428]. https://doi.org/10.1098/rstb.2015.0428

Vancouver

Verkhratsky A, Nedergaard M. The homeostatic astroglia emerges from evolutionary specialization of neural cells. Royal Society of London. Philosophical Transactions B. Biological Sciences. 2016 Aug 5;371(1700):1-11. 20150428. https://doi.org/10.1098/rstb.2015.0428

Author

Verkhratsky, Alexei ; Nedergaard, Maiken. / The homeostatic astroglia emerges from evolutionary specialization of neural cells. In: Royal Society of London. Philosophical Transactions B. Biological Sciences. 2016 ; Vol. 371, No. 1700. pp. 1-11.

Bibtex

@article{115f8583284f4b81ab4f71a5acfcfe46,
title = "The homeostatic astroglia emerges from evolutionary specialization of neural cells",
abstract = "Evolution of the nervous system progressed through cellular diversification and specialization of functions. Conceptually, the nervous system is composed from electrically excitable neuronal networks connected with chemical synapses and non-excitable glial cells that provide for homeostasis and defence. Astrocytes are integrated into neural networks through multipartite synapses; astroglial perisynaptic processes closely enwrap synaptic contacts and control homeostasis of the synaptic cleft, supply neurons with glutamate and GABA obligatory precursor glutamine and contribute to synaptic plasticity, learning and memory. In neuropathology, astrocytes may undergo reactive remodelling or degeneration; to a large extent, astroglial reactions define progression of the pathology and neurological outcome.This article is part of the themed issue 'Evolution brings Ca(2+) and ATP together to control life and death'.",
keywords = "Journal Article, Review",
author = "Alexei Verkhratsky and Maiken Nedergaard",
note = "{\textcopyright} 2016 The Author(s).",
year = "2016",
month = aug,
day = "5",
doi = "10.1098/rstb.2015.0428",
language = "English",
volume = "371",
pages = "1--11",
journal = "Philosophical Transactions of the Royal Society B: Biological Sciences",
issn = "0962-8436",
publisher = "The/Royal Society",
number = "1700",

}

RIS

TY - JOUR

T1 - The homeostatic astroglia emerges from evolutionary specialization of neural cells

AU - Verkhratsky, Alexei

AU - Nedergaard, Maiken

N1 - © 2016 The Author(s).

PY - 2016/8/5

Y1 - 2016/8/5

N2 - Evolution of the nervous system progressed through cellular diversification and specialization of functions. Conceptually, the nervous system is composed from electrically excitable neuronal networks connected with chemical synapses and non-excitable glial cells that provide for homeostasis and defence. Astrocytes are integrated into neural networks through multipartite synapses; astroglial perisynaptic processes closely enwrap synaptic contacts and control homeostasis of the synaptic cleft, supply neurons with glutamate and GABA obligatory precursor glutamine and contribute to synaptic plasticity, learning and memory. In neuropathology, astrocytes may undergo reactive remodelling or degeneration; to a large extent, astroglial reactions define progression of the pathology and neurological outcome.This article is part of the themed issue 'Evolution brings Ca(2+) and ATP together to control life and death'.

AB - Evolution of the nervous system progressed through cellular diversification and specialization of functions. Conceptually, the nervous system is composed from electrically excitable neuronal networks connected with chemical synapses and non-excitable glial cells that provide for homeostasis and defence. Astrocytes are integrated into neural networks through multipartite synapses; astroglial perisynaptic processes closely enwrap synaptic contacts and control homeostasis of the synaptic cleft, supply neurons with glutamate and GABA obligatory precursor glutamine and contribute to synaptic plasticity, learning and memory. In neuropathology, astrocytes may undergo reactive remodelling or degeneration; to a large extent, astroglial reactions define progression of the pathology and neurological outcome.This article is part of the themed issue 'Evolution brings Ca(2+) and ATP together to control life and death'.

KW - Journal Article

KW - Review

U2 - 10.1098/rstb.2015.0428

DO - 10.1098/rstb.2015.0428

M3 - Journal article

C2 - 27377722

VL - 371

SP - 1

EP - 11

JO - Philosophical Transactions of the Royal Society B: Biological Sciences

JF - Philosophical Transactions of the Royal Society B: Biological Sciences

SN - 0962-8436

IS - 1700

M1 - 20150428

ER -

ID: 164971726