The Glymphatic System and Pain

Research output: Contribution to journal › Journal article › Research › peer-review

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The Glymphatic System and Pain. / Goldman, Nanna; Hablitz, Lauren M.; Mori, Yuki; Nedergaard, Maiken.

In: Medical Acupuncture, Vol. 32, No. 6, 2020, p. 373-376.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Goldman, N, Hablitz, LM, Mori, Y & Nedergaard, M 2020, 'The Glymphatic System and Pain', Medical Acupuncture, vol. 32, no. 6, pp. 373-376. https://doi.org/10.1089/acu.2020.1489

APA

Goldman, N., Hablitz, L. M., Mori, Y., & Nedergaard, M. (2020). The Glymphatic System and Pain. Medical Acupuncture, 32(6), 373-376. https://doi.org/10.1089/acu.2020.1489

Vancouver

Goldman N, Hablitz LM, Mori Y, Nedergaard M. The Glymphatic System and Pain. Medical Acupuncture. 2020;32(6):373-376. https://doi.org/10.1089/acu.2020.1489

Author

Goldman, Nanna ; Hablitz, Lauren M. ; Mori, Yuki ; Nedergaard, Maiken. / The Glymphatic System and Pain. In: Medical Acupuncture. 2020 ; Vol. 32, No. 6. pp. 373-376.

Bibtex

@article{f2846877f2264cf5b76a2f53832cbbfa,
title = "The Glymphatic System and Pain",
abstract = "The glymphatic system is network of perivascular spaces through which cerebrospinal fluid and interstitial fluid can move through the brain, clearing metabolic waste, such as amyloid beta, lactate and more, from the parenchyma. This cleaning system is regulated by sleep and norepinephrine, with increased levels of norepinephrine during wakefulness inhibiting fluid movement. Norepinephrine is also essential for transition from acute to chronic pain, and sufferers of chronic neuropathic pain frequently present with sleep disruption. These connections among glymphatic clearance, sleep, and pain are very intriguing, and might lead to nonpharmaceutical interventions for pain treatment. This short perspective provides a rationale for the hypothesis that mind-body interventions - such as acupuncture - can reduce norepinephrine and increase glymphatic function, ultimately relieving chronic neuropathic pain.",
keywords = "acupuncture, chronic neuropathic pain, glymphatic, neuroinflammation, norepinephrine",
author = "Nanna Goldman and Hablitz, {Lauren M.} and Yuki Mori and Maiken Nedergaard",
year = "2020",
doi = "10.1089/acu.2020.1489",
language = "English",
volume = "32",
pages = "373--376",
journal = "Medical Acupuncture",
issn = "1933-6586",
publisher = "Mary Ann Liebert Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - The Glymphatic System and Pain

AU - Goldman, Nanna

AU - Hablitz, Lauren M.

AU - Mori, Yuki

AU - Nedergaard, Maiken

PY - 2020

Y1 - 2020

N2 - The glymphatic system is network of perivascular spaces through which cerebrospinal fluid and interstitial fluid can move through the brain, clearing metabolic waste, such as amyloid beta, lactate and more, from the parenchyma. This cleaning system is regulated by sleep and norepinephrine, with increased levels of norepinephrine during wakefulness inhibiting fluid movement. Norepinephrine is also essential for transition from acute to chronic pain, and sufferers of chronic neuropathic pain frequently present with sleep disruption. These connections among glymphatic clearance, sleep, and pain are very intriguing, and might lead to nonpharmaceutical interventions for pain treatment. This short perspective provides a rationale for the hypothesis that mind-body interventions - such as acupuncture - can reduce norepinephrine and increase glymphatic function, ultimately relieving chronic neuropathic pain.

AB - The glymphatic system is network of perivascular spaces through which cerebrospinal fluid and interstitial fluid can move through the brain, clearing metabolic waste, such as amyloid beta, lactate and more, from the parenchyma. This cleaning system is regulated by sleep and norepinephrine, with increased levels of norepinephrine during wakefulness inhibiting fluid movement. Norepinephrine is also essential for transition from acute to chronic pain, and sufferers of chronic neuropathic pain frequently present with sleep disruption. These connections among glymphatic clearance, sleep, and pain are very intriguing, and might lead to nonpharmaceutical interventions for pain treatment. This short perspective provides a rationale for the hypothesis that mind-body interventions - such as acupuncture - can reduce norepinephrine and increase glymphatic function, ultimately relieving chronic neuropathic pain.

KW - acupuncture

KW - chronic neuropathic pain

KW - glymphatic

KW - neuroinflammation

KW - norepinephrine

U2 - 10.1089/acu.2020.1489

DO - 10.1089/acu.2020.1489

M3 - Journal article

C2 - 33362890

AN - SCOPUS:85098081795

VL - 32

SP - 373

EP - 376

JO - Medical Acupuncture

JF - Medical Acupuncture

SN - 1933-6586

IS - 6

ER -

ID: 253780047