The glymphatic system: Current understanding and modeling

Research output: Contribution to journal › Review › Research › peer-review

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The glymphatic system : Current understanding and modeling. / Bohr, Tomas; Hjorth, Poul G.; Holst, Sebastian C.; Hrabětová, Sabina; Kiviniemi, Vesa; Lilius, Tuomas; Lundgaard, Iben; Mardal, Kent Andre; Martens, Erik A.; Mori, Yuki; Nägerl, U. Valentin; Nicholson, Charles; Tannenbaum, Allen; Thomas, John H.; Tithof, Jeffrey; Benveniste, Helene; Iliff, Jeffrey J.; Kelley, Douglas H.; Nedergaard, Maiken.

In: iScience, Vol. 25, No. 9, 104987, 2022.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Bohr, T, Hjorth, PG, Holst, SC, Hrabětová, S, Kiviniemi, V, Lilius, T, Lundgaard, I, Mardal, KA, Martens, EA, Mori, Y, Nägerl, UV, Nicholson, C, Tannenbaum, A, Thomas, JH, Tithof, J, Benveniste, H, Iliff, JJ, Kelley, DH & Nedergaard, M 2022, 'The glymphatic system: Current understanding and modeling', iScience, vol. 25, no. 9, 104987. https://doi.org/10.1016/j.isci.2022.104987

APA

Bohr, T., Hjorth, P. G., Holst, S. C., Hrabětová, S., Kiviniemi, V., Lilius, T., Lundgaard, I., Mardal, K. A., Martens, E. A., Mori, Y., Nägerl, U. V., Nicholson, C., Tannenbaum, A., Thomas, J. H., Tithof, J., Benveniste, H., Iliff, J. J., Kelley, D. H., & Nedergaard, M. (2022). The glymphatic system: Current understanding and modeling. iScience, 25(9), [104987]. https://doi.org/10.1016/j.isci.2022.104987

Vancouver

Bohr T, Hjorth PG, Holst SC, Hrabětová S, Kiviniemi V, Lilius T et al. The glymphatic system: Current understanding and modeling. iScience. 2022;25(9). 104987. https://doi.org/10.1016/j.isci.2022.104987

Author

Bohr, Tomas ; Hjorth, Poul G. ; Holst, Sebastian C. ; Hrabětová, Sabina ; Kiviniemi, Vesa ; Lilius, Tuomas ; Lundgaard, Iben ; Mardal, Kent Andre ; Martens, Erik A. ; Mori, Yuki ; Nägerl, U. Valentin ; Nicholson, Charles ; Tannenbaum, Allen ; Thomas, John H. ; Tithof, Jeffrey ; Benveniste, Helene ; Iliff, Jeffrey J. ; Kelley, Douglas H. ; Nedergaard, Maiken. / The glymphatic system : Current understanding and modeling. In: iScience. 2022 ; Vol. 25, No. 9.

Bibtex

@article{d9d8b8b906f948fc8e6edf8442c4fc8e,
title = "The glymphatic system: Current understanding and modeling",
abstract = "We review theoretical and numerical models of the glymphatic system, which circulates cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models enable hypothesis development and predictions of transport, with clinical applications including drug delivery, stroke, cardiac arrest, and neurodegenerative disorders like Alzheimer's disease. We sort existing models into broad categories by anatomical function: Perivascular flow, transport in brain parenchyma, interfaces to perivascular spaces, efflux routes, and links to neuronal activity. Needs and opportunities for future work are highlighted wherever possible; new models, expanded models, and novel experiments to inform models could all have tremendous value for advancing the field.",
keywords = "Neuroanatomy, Neuroscience, Systems biology",
author = "Tomas Bohr and Hjorth, {Poul G.} and Holst, {Sebastian C.} and Sabina Hrab{\v e}tov{\'a} and Vesa Kiviniemi and Tuomas Lilius and Iben Lundgaard and Mardal, {Kent Andre} and Martens, {Erik A.} and Yuki Mori and N{\"a}gerl, {U. Valentin} and Charles Nicholson and Allen Tannenbaum and Thomas, {John H.} and Jeffrey Tithof and Helene Benveniste and Iliff, {Jeffrey J.} and Kelley, {Douglas H.} and Maiken Nedergaard",
note = "Publisher Copyright: {\textcopyright} 2022 The Author(s)",
year = "2022",
doi = "10.1016/j.isci.2022.104987",
language = "English",
volume = "25",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier",
number = "9",

}

RIS

TY - JOUR

T1 - The glymphatic system

T2 - Current understanding and modeling

AU - Bohr, Tomas

AU - Hjorth, Poul G.

AU - Holst, Sebastian C.

AU - Hrabětová, Sabina

AU - Kiviniemi, Vesa

AU - Lilius, Tuomas

AU - Lundgaard, Iben

AU - Mardal, Kent Andre

AU - Martens, Erik A.

AU - Mori, Yuki

AU - Nägerl, U. Valentin

AU - Nicholson, Charles

AU - Tannenbaum, Allen

AU - Thomas, John H.

AU - Tithof, Jeffrey

AU - Benveniste, Helene

AU - Iliff, Jeffrey J.

AU - Kelley, Douglas H.

AU - Nedergaard, Maiken

N1 - Publisher Copyright: © 2022 The Author(s)

PY - 2022

Y1 - 2022

N2 - We review theoretical and numerical models of the glymphatic system, which circulates cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models enable hypothesis development and predictions of transport, with clinical applications including drug delivery, stroke, cardiac arrest, and neurodegenerative disorders like Alzheimer's disease. We sort existing models into broad categories by anatomical function: Perivascular flow, transport in brain parenchyma, interfaces to perivascular spaces, efflux routes, and links to neuronal activity. Needs and opportunities for future work are highlighted wherever possible; new models, expanded models, and novel experiments to inform models could all have tremendous value for advancing the field.

AB - We review theoretical and numerical models of the glymphatic system, which circulates cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models enable hypothesis development and predictions of transport, with clinical applications including drug delivery, stroke, cardiac arrest, and neurodegenerative disorders like Alzheimer's disease. We sort existing models into broad categories by anatomical function: Perivascular flow, transport in brain parenchyma, interfaces to perivascular spaces, efflux routes, and links to neuronal activity. Needs and opportunities for future work are highlighted wherever possible; new models, expanded models, and novel experiments to inform models could all have tremendous value for advancing the field.

KW - Neuroanatomy

KW - Neuroscience

KW - Systems biology

U2 - 10.1016/j.isci.2022.104987

DO - 10.1016/j.isci.2022.104987

M3 - Review

C2 - 36093063

AN - SCOPUS:85137084204

VL - 25

JO - iScience

JF - iScience

SN - 2589-0042

IS - 9

M1 - 104987

ER -

ID: 319648723