The glymphatic system: implications for drugs for central nervous system diseases

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The glymphatic system : implications for drugs for central nervous system diseases. / Lohela, Terhi J.; Lilius, Tuomas O.; Nedergaard, Maiken.

In: Nature Reviews Drug Discovery, Vol. 21, No. 10, 2022, p. 763-779.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Lohela, TJ, Lilius, TO & Nedergaard, M 2022, 'The glymphatic system: implications for drugs for central nervous system diseases', Nature Reviews Drug Discovery, vol. 21, no. 10, pp. 763-779. https://doi.org/10.1038/s41573-022-00500-9

APA

Lohela, T. J., Lilius, T. O., & Nedergaard, M. (2022). The glymphatic system: implications for drugs for central nervous system diseases. Nature Reviews Drug Discovery, 21(10), 763-779. https://doi.org/10.1038/s41573-022-00500-9

Vancouver

Lohela TJ, Lilius TO, Nedergaard M. The glymphatic system: implications for drugs for central nervous system diseases. Nature Reviews Drug Discovery. 2022;21(10):763-779. https://doi.org/10.1038/s41573-022-00500-9

Author

Lohela, Terhi J. ; Lilius, Tuomas O. ; Nedergaard, Maiken. / The glymphatic system : implications for drugs for central nervous system diseases. In: Nature Reviews Drug Discovery. 2022 ; Vol. 21, No. 10. pp. 763-779.

Bibtex

@article{574e7e191eab4913ac45478e082d6e96,
title = "The glymphatic system: implications for drugs for central nervous system diseases",
abstract = "In the past decade, evidence for a fluid clearance pathway in the central nervous system known as the glymphatic system has grown. According to the glymphatic system concept, cerebrospinal fluid flows directionally through the brain and non-selectively clears the interstitium of metabolic waste. Importantly, the glymphatic system may be modulated by particular drugs such as anaesthetics, as well as by non-pharmacological factors such as sleep, and its dysfunction has been implicated in central nervous system disorders such as Alzheimer disease. Although the glymphatic system is best described in rodents, reports using multiple neuroimaging modalities indicate that a similar transport system exists in the human brain. Here, we overview the evidence for the glymphatic system and its role in disease and discuss opportunities to harness the glymphatic system therapeutically; for example, by improving the effectiveness of intrathecally delivered drugs.",
author = "Lohela, {Terhi J.} and Lilius, {Tuomas O.} and Maiken Nedergaard",
note = "Publisher Copyright: {\textcopyright} 2022, Springer Nature Limited.",
year = "2022",
doi = "10.1038/s41573-022-00500-9",
language = "English",
volume = "21",
pages = "763--779",
journal = "Nature Reviews. Drug Discovery",
issn = "1474-1776",
publisher = "nature publishing group",
number = "10",

}

RIS

TY - JOUR

T1 - The glymphatic system

T2 - implications for drugs for central nervous system diseases

AU - Lohela, Terhi J.

AU - Lilius, Tuomas O.

AU - Nedergaard, Maiken

N1 - Publisher Copyright: © 2022, Springer Nature Limited.

PY - 2022

Y1 - 2022

N2 - In the past decade, evidence for a fluid clearance pathway in the central nervous system known as the glymphatic system has grown. According to the glymphatic system concept, cerebrospinal fluid flows directionally through the brain and non-selectively clears the interstitium of metabolic waste. Importantly, the glymphatic system may be modulated by particular drugs such as anaesthetics, as well as by non-pharmacological factors such as sleep, and its dysfunction has been implicated in central nervous system disorders such as Alzheimer disease. Although the glymphatic system is best described in rodents, reports using multiple neuroimaging modalities indicate that a similar transport system exists in the human brain. Here, we overview the evidence for the glymphatic system and its role in disease and discuss opportunities to harness the glymphatic system therapeutically; for example, by improving the effectiveness of intrathecally delivered drugs.

AB - In the past decade, evidence for a fluid clearance pathway in the central nervous system known as the glymphatic system has grown. According to the glymphatic system concept, cerebrospinal fluid flows directionally through the brain and non-selectively clears the interstitium of metabolic waste. Importantly, the glymphatic system may be modulated by particular drugs such as anaesthetics, as well as by non-pharmacological factors such as sleep, and its dysfunction has been implicated in central nervous system disorders such as Alzheimer disease. Although the glymphatic system is best described in rodents, reports using multiple neuroimaging modalities indicate that a similar transport system exists in the human brain. Here, we overview the evidence for the glymphatic system and its role in disease and discuss opportunities to harness the glymphatic system therapeutically; for example, by improving the effectiveness of intrathecally delivered drugs.

U2 - 10.1038/s41573-022-00500-9

DO - 10.1038/s41573-022-00500-9

M3 - Journal article

C2 - 35948785

AN - SCOPUS:85136974117

VL - 21

SP - 763

EP - 779

JO - Nature Reviews. Drug Discovery

JF - Nature Reviews. Drug Discovery

SN - 1474-1776

IS - 10

ER -

ID: 342565307