Surface periarterial spaces of the mouse brain are open, not porous

Research output: Contribution to journal › Journal article › Research › peer-review

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Surface periarterial spaces of the mouse brain are open, not porous. / Min Rivas, Fatima; Liu, Jia; Martell, Benjamin C.; Du, Ting; Mestre, Humberto; Nedergaard, Maiken; Tithof, Jeffrey; Thomas, John H.; Kelley, Douglas H.

In: Journal of the Royal Society, Interface, Vol. 17, No. 172, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Min Rivas, F, Liu, J, Martell, BC, Du, T, Mestre, H, Nedergaard, M, Tithof, J, Thomas, JH & Kelley, DH 2020, 'Surface periarterial spaces of the mouse brain are open, not porous', Journal of the Royal Society, Interface, vol. 17, no. 172. https://doi.org/10.1098/rsif.2020.0593

APA

Min Rivas, F., Liu, J., Martell, B. C., Du, T., Mestre, H., Nedergaard, M., Tithof, J., Thomas, J. H., & Kelley, D. H. (2020). Surface periarterial spaces of the mouse brain are open, not porous. Journal of the Royal Society, Interface, 17(172). https://doi.org/10.1098/rsif.2020.0593

Vancouver

Min Rivas F, Liu J, Martell BC, Du T, Mestre H, Nedergaard M et al. Surface periarterial spaces of the mouse brain are open, not porous. Journal of the Royal Society, Interface. 2020;17(172). https://doi.org/10.1098/rsif.2020.0593

Author

Min Rivas, Fatima ; Liu, Jia ; Martell, Benjamin C. ; Du, Ting ; Mestre, Humberto ; Nedergaard, Maiken ; Tithof, Jeffrey ; Thomas, John H. ; Kelley, Douglas H. / Surface periarterial spaces of the mouse brain are open, not porous. In: Journal of the Royal Society, Interface. 2020 ; Vol. 17, No. 172.

Bibtex

@article{f31a7f5a176543e999b64758605e816e,
title = "Surface periarterial spaces of the mouse brain are open, not porous",
abstract = "Fluid-dynamic models of the flow of cerebrospinal fluid in the brain have treated the perivascular spaces either as open (without internal solid obstacles) or as porous. Here, we present experimental evidence that pial (surface) periarterial spaces in mice are essentially open. (1) Paths of particles in the perivascular spaces are smooth, as expected for viscous flow in an open vessel, not diffusive, as expected for flow in a porous medium. (2) Time-averaged velocity profiles in periarterial spaces agree closely with theoretical profiles for viscous flow in realistic models, but not with the nearly uniform profiles expected for porous medium. Because these spaces are open, they have much lower hydraulic resistance than if they were porous. To demonstrate, we compute hydraulic resistance for realistic periarterial spaces, both open and porous, and show that the resistance of the porous spaces are greater, typically by a factor of a hundred or more. The open nature of these periarterial spaces allows significantly greater flow rates and more efficient removal of metabolic waste products.",
keywords = "brain clearance system, cerebrospinal fluid, fluid dynamics, glymphatic system, hydraulic network models, perivascular spaces",
author = "{Min Rivas}, Fatima and Jia Liu and Martell, {Benjamin C.} and Ting Du and Humberto Mestre and Maiken Nedergaard and Jeffrey Tithof and Thomas, {John H.} and Kelley, {Douglas H.}",
year = "2020",
doi = "10.1098/rsif.2020.0593",
language = "English",
volume = "17",
journal = "Journal of the Royal Society. Interface",
issn = "1742-5689",
publisher = "The/Royal Society",
number = "172",

}

RIS

TY - JOUR

T1 - Surface periarterial spaces of the mouse brain are open, not porous

AU - Min Rivas, Fatima

AU - Liu, Jia

AU - Martell, Benjamin C.

AU - Du, Ting

AU - Mestre, Humberto

AU - Nedergaard, Maiken

AU - Tithof, Jeffrey

AU - Thomas, John H.

AU - Kelley, Douglas H.

PY - 2020

Y1 - 2020

N2 - Fluid-dynamic models of the flow of cerebrospinal fluid in the brain have treated the perivascular spaces either as open (without internal solid obstacles) or as porous. Here, we present experimental evidence that pial (surface) periarterial spaces in mice are essentially open. (1) Paths of particles in the perivascular spaces are smooth, as expected for viscous flow in an open vessel, not diffusive, as expected for flow in a porous medium. (2) Time-averaged velocity profiles in periarterial spaces agree closely with theoretical profiles for viscous flow in realistic models, but not with the nearly uniform profiles expected for porous medium. Because these spaces are open, they have much lower hydraulic resistance than if they were porous. To demonstrate, we compute hydraulic resistance for realistic periarterial spaces, both open and porous, and show that the resistance of the porous spaces are greater, typically by a factor of a hundred or more. The open nature of these periarterial spaces allows significantly greater flow rates and more efficient removal of metabolic waste products.

AB - Fluid-dynamic models of the flow of cerebrospinal fluid in the brain have treated the perivascular spaces either as open (without internal solid obstacles) or as porous. Here, we present experimental evidence that pial (surface) periarterial spaces in mice are essentially open. (1) Paths of particles in the perivascular spaces are smooth, as expected for viscous flow in an open vessel, not diffusive, as expected for flow in a porous medium. (2) Time-averaged velocity profiles in periarterial spaces agree closely with theoretical profiles for viscous flow in realistic models, but not with the nearly uniform profiles expected for porous medium. Because these spaces are open, they have much lower hydraulic resistance than if they were porous. To demonstrate, we compute hydraulic resistance for realistic periarterial spaces, both open and porous, and show that the resistance of the porous spaces are greater, typically by a factor of a hundred or more. The open nature of these periarterial spaces allows significantly greater flow rates and more efficient removal of metabolic waste products.

KW - brain clearance system

KW - cerebrospinal fluid

KW - fluid dynamics

KW - glymphatic system

KW - hydraulic network models

KW - perivascular spaces

U2 - 10.1098/rsif.2020.0593

DO - 10.1098/rsif.2020.0593

M3 - Journal article

C2 - 33171075

AN - SCOPUS:85095541159

VL - 17

JO - Journal of the Royal Society. Interface

JF - Journal of the Royal Society. Interface

SN - 1742-5689

IS - 172

ER -

ID: 252549868