Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease
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Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease. / Fox, Ira J; Daley, George Q; Goldman, Steven A; Huard, Johnny; Kamp, Timothy J; Trucco, Massimo.
In: Science (New York, N.Y.), Vol. 345, No. 6199, 1247391, 22.08.2014, p. 1-12.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease
AU - Fox, Ira J
AU - Daley, George Q
AU - Goldman, Steven A
AU - Huard, Johnny
AU - Kamp, Timothy J
AU - Trucco, Massimo
N1 - Copyright © 2014, American Association for the Advancement of Science.
PY - 2014/8/22
Y1 - 2014/8/22
N2 - Pluripotent stem cells (PSCs) directed to various cell fates holds promise as source material for treating numerous disorders. The availability of precisely differentiated PSC-derived cells will dramatically affect blood component and hematopoietic stem cell therapies and should facilitate treatment of diabetes, some forms of liver disease and neurologic disorders, retinal diseases, and possibly heart disease. Although an unlimited supply of specific cell types is needed, other barriers must be overcome. This review of the state of cell therapies highlights important challenges. Successful cell transplantation will require optimizing the best cell type and site for engraftment, overcoming limitations to cell migration and tissue integration, and occasionally needing to control immunologic reactivity, as well as a number of other challenges. Collaboration among scientists, clinicians, and industry is critical for generating new stem cell-based therapies.
AB - Pluripotent stem cells (PSCs) directed to various cell fates holds promise as source material for treating numerous disorders. The availability of precisely differentiated PSC-derived cells will dramatically affect blood component and hematopoietic stem cell therapies and should facilitate treatment of diabetes, some forms of liver disease and neurologic disorders, retinal diseases, and possibly heart disease. Although an unlimited supply of specific cell types is needed, other barriers must be overcome. This review of the state of cell therapies highlights important challenges. Successful cell transplantation will require optimizing the best cell type and site for engraftment, overcoming limitations to cell migration and tissue integration, and occasionally needing to control immunologic reactivity, as well as a number of other challenges. Collaboration among scientists, clinicians, and industry is critical for generating new stem cell-based therapies.
KW - Cell Differentiation
KW - Cell- and Tissue-Based Therapy
KW - Heart Diseases
KW - Humans
KW - Muscular Diseases
KW - Nervous System Diseases
KW - Pancreatic Diseases
KW - Pluripotent Stem Cells
KW - Regeneration
KW - Regenerative Medicine
U2 - 10.1126/science.1247391
DO - 10.1126/science.1247391
M3 - Review
C2 - 25146295
VL - 345
SP - 1
EP - 12
JO - Science
JF - Science
SN - 0036-8075
IS - 6199
M1 - 1247391
ER -
ID: 128373857