Remyelination in the Central Nervous System
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Remyelination in the Central Nervous System. / Franklin, Robin J.M.; Bodini, Benedetta; Goldman, Steven A.
In: Cold Spring Harbor perspectives in biology, Vol. 16, No. 3, a041371, 2024.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Remyelination in the Central Nervous System
AU - Franklin, Robin J.M.
AU - Bodini, Benedetta
AU - Goldman, Steven A.
N1 - Publisher Copyright: © 2024 Cold Spring Harbor Laboratory Press; all rights reserved.
PY - 2024
Y1 - 2024
N2 - The inability of the mammalian central nervous system (CNS) to undergo spontaneous regeneration has long been regarded as a central tenet of neurobiology. However, while this is largely true of the neuronal elements of the adult mammalian CNS, save for discrete populations of granule neurons, the same is not true of its glial elements. In particular, the loss of oligodendrocytes, which results in demyelination, triggers a spontaneous and often highly efficient regenerative response, remyelination, in which new oligodendrocytes are generated and myelin sheaths are restored to denuded axons. Yet remyelination in humans is not without limitation, and a variety of demyelinating conditions are associated with sustained and disabling myelin loss. In this work, we will (1) review the biology of remyelination, including the cells and signals involved; (2) describe when remyelination occurs and when and why it fails, including the consequences of its failure; and (3) discuss approaches for therapeutically enhancing remyelination in demyelinating diseases of both children and adults, both by stimulating endogenous oligodendrocyte progenitor cells and by transplanting these cells into demyelinated brain.
AB - The inability of the mammalian central nervous system (CNS) to undergo spontaneous regeneration has long been regarded as a central tenet of neurobiology. However, while this is largely true of the neuronal elements of the adult mammalian CNS, save for discrete populations of granule neurons, the same is not true of its glial elements. In particular, the loss of oligodendrocytes, which results in demyelination, triggers a spontaneous and often highly efficient regenerative response, remyelination, in which new oligodendrocytes are generated and myelin sheaths are restored to denuded axons. Yet remyelination in humans is not without limitation, and a variety of demyelinating conditions are associated with sustained and disabling myelin loss. In this work, we will (1) review the biology of remyelination, including the cells and signals involved; (2) describe when remyelination occurs and when and why it fails, including the consequences of its failure; and (3) discuss approaches for therapeutically enhancing remyelination in demyelinating diseases of both children and adults, both by stimulating endogenous oligodendrocyte progenitor cells and by transplanting these cells into demyelinated brain.
U2 - 10.1101/cshperspect.a041371
DO - 10.1101/cshperspect.a041371
M3 - Journal article
C2 - 38316552
AN - SCOPUS:85186489652
VL - 16
JO - Cold Spring Harbor Perspectives in Biology
JF - Cold Spring Harbor Perspectives in Biology
SN - 1943-0264
IS - 3
M1 - a041371
ER -
ID: 385231108