Reactive astrocyte nomenclature, definitions, and future directions

Research output: Contribution to journal › Journal article › Research › peer-review

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Reactive astrocyte nomenclature, definitions, and future directions. / Escartin, Carole; Galea, Elena; Lakatos, Andras; O'Callaghan, James P.; Petzold, Gabor C.; Serrano-Pozo, Alberto; Steinhauser, Christian; Volterra, Andrea; Carmignoto, Giorgio; Agarwal, Amit; Allen, Nicola J.; Araque, Alfonso; Barbeito, Luis; Barzilai, Ari; Bergles, Dwight E.; Bonvento, Gilles; Butt, Arthur M.; Chen, Wei-Ting; Cohen-Salmon, Martine; Cunningham, Colm; Deneen, Benjamin; De Strooper, Bart; Diaz-Castro, Blanca; Farina, Cinthia; Freeman, Marc; Gallo, Vittorio; Goldman, James E.; Goldman, Steven A.; Gotz, Magdalena; Gutierrez, Antonia; Haydon, Philip G.; Heiland, Dieter H.; Hol, Elly M.; Holt, Matthew G.; Iino, Masamitsu; Kastanenka, Ksenia V.; Kettenmann, Helmut; Khakh, Baljit S.; Koizumi, Schuichi; Lee, C. Justin; Liddelow, Shane A.; MacVicar, Brian A.; Magistretti, Pierre; Messing, Albee; Mishra, Anusha; Molofsky, Anna V.; Murai, Keith K.; Norris, Christopher M.; Okada, Seiji; Oliet, Stephane H. R.; Oliveira, Joao F.; Panatier, Aude; Parpura, Vladimir; Pekna, Marcela; Pekny, Milos; Pellerin, Luc; Perea, Gertrudis; Perez-Nievas, Beatriz G.; Pfrieger, Frank W.; Poskanzer, Kira E.; Quintana, Francisco J.; Ransohoff, Richard M.; Riquelme-Perez, Miriam; Robel, Stefanie; Rose, Christine R.; Rothstein, Jeffrey D.; Rouach, Nathalie; Rowitch, David H.; Semyanov, Alexey; Sirko, Swetlana; Sontheimer, Harald; Swanson, Raymond A.; Vitorica, Javier; Wanner, Ina-Beate; Wood, Levi B.; Wu, Jiaqian; Zheng, Binhai; Zimmer, Eduardo R.; Zorec, Robert; Sofroniew, Michael V.; Verkhratsky, Alexei.

In: Nature Neuroscience, Vol. 24, 2021, p. 312–325.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Escartin, C, Galea, E, Lakatos, A, O'Callaghan, JP, Petzold, GC, Serrano-Pozo, A, Steinhauser, C, Volterra, A, Carmignoto, G, Agarwal, A, Allen, NJ, Araque, A, Barbeito, L, Barzilai, A, Bergles, DE, Bonvento, G, Butt, AM, Chen, W-T, Cohen-Salmon, M, Cunningham, C, Deneen, B, De Strooper, B, Diaz-Castro, B, Farina, C, Freeman, M, Gallo, V, Goldman, JE, Goldman, SA, Gotz, M, Gutierrez, A, Haydon, PG, Heiland, DH, Hol, EM, Holt, MG, Iino, M, Kastanenka, KV, Kettenmann, H, Khakh, BS, Koizumi, S, Lee, CJ, Liddelow, SA, MacVicar, BA, Magistretti, P, Messing, A, Mishra, A, Molofsky, AV, Murai, KK, Norris, CM, Okada, S, Oliet, SHR, Oliveira, JF, Panatier, A, Parpura, V, Pekna, M, Pekny, M, Pellerin, L, Perea, G, Perez-Nievas, BG, Pfrieger, FW, Poskanzer, KE, Quintana, FJ, Ransohoff, RM, Riquelme-Perez, M, Robel, S, Rose, CR, Rothstein, JD, Rouach, N, Rowitch, DH, Semyanov, A, Sirko, S, Sontheimer, H, Swanson, RA, Vitorica, J, Wanner, I-B, Wood, LB, Wu, J, Zheng, B, Zimmer, ER, Zorec, R, Sofroniew, MV & Verkhratsky, A 2021, 'Reactive astrocyte nomenclature, definitions, and future directions', Nature Neuroscience, vol. 24, pp. 312–325. https://doi.org/10.1038/s41593-020-00783-4

APA

Escartin, C., Galea, E., Lakatos, A., O'Callaghan, J. P., Petzold, G. C., Serrano-Pozo, A., Steinhauser, C., Volterra, A., Carmignoto, G., Agarwal, A., Allen, N. J., Araque, A., Barbeito, L., Barzilai, A., Bergles, D. E., Bonvento, G., Butt, A. M., Chen, W-T., Cohen-Salmon, M., ... Verkhratsky, A. (2021). Reactive astrocyte nomenclature, definitions, and future directions. Nature Neuroscience, 24, 312–325. https://doi.org/10.1038/s41593-020-00783-4

Vancouver

Escartin C, Galea E, Lakatos A, O'Callaghan JP, Petzold GC, Serrano-Pozo A et al. Reactive astrocyte nomenclature, definitions, and future directions. Nature Neuroscience. 2021;24:312–325. https://doi.org/10.1038/s41593-020-00783-4

Author

Escartin, Carole ; Galea, Elena ; Lakatos, Andras ; O'Callaghan, James P. ; Petzold, Gabor C. ; Serrano-Pozo, Alberto ; Steinhauser, Christian ; Volterra, Andrea ; Carmignoto, Giorgio ; Agarwal, Amit ; Allen, Nicola J. ; Araque, Alfonso ; Barbeito, Luis ; Barzilai, Ari ; Bergles, Dwight E. ; Bonvento, Gilles ; Butt, Arthur M. ; Chen, Wei-Ting ; Cohen-Salmon, Martine ; Cunningham, Colm ; Deneen, Benjamin ; De Strooper, Bart ; Diaz-Castro, Blanca ; Farina, Cinthia ; Freeman, Marc ; Gallo, Vittorio ; Goldman, James E. ; Goldman, Steven A. ; Gotz, Magdalena ; Gutierrez, Antonia ; Haydon, Philip G. ; Heiland, Dieter H. ; Hol, Elly M. ; Holt, Matthew G. ; Iino, Masamitsu ; Kastanenka, Ksenia V. ; Kettenmann, Helmut ; Khakh, Baljit S. ; Koizumi, Schuichi ; Lee, C. Justin ; Liddelow, Shane A. ; MacVicar, Brian A. ; Magistretti, Pierre ; Messing, Albee ; Mishra, Anusha ; Molofsky, Anna V. ; Murai, Keith K. ; Norris, Christopher M. ; Okada, Seiji ; Oliet, Stephane H. R. ; Oliveira, Joao F. ; Panatier, Aude ; Parpura, Vladimir ; Pekna, Marcela ; Pekny, Milos ; Pellerin, Luc ; Perea, Gertrudis ; Perez-Nievas, Beatriz G. ; Pfrieger, Frank W. ; Poskanzer, Kira E. ; Quintana, Francisco J. ; Ransohoff, Richard M. ; Riquelme-Perez, Miriam ; Robel, Stefanie ; Rose, Christine R. ; Rothstein, Jeffrey D. ; Rouach, Nathalie ; Rowitch, David H. ; Semyanov, Alexey ; Sirko, Swetlana ; Sontheimer, Harald ; Swanson, Raymond A. ; Vitorica, Javier ; Wanner, Ina-Beate ; Wood, Levi B. ; Wu, Jiaqian ; Zheng, Binhai ; Zimmer, Eduardo R. ; Zorec, Robert ; Sofroniew, Michael V. ; Verkhratsky, Alexei. / Reactive astrocyte nomenclature, definitions, and future directions. In: Nature Neuroscience. 2021 ; Vol. 24. pp. 312–325.

Bibtex

@article{a85c1ee6f90a4be1b995e0bc176e3722,
title = "Reactive astrocyte nomenclature, definitions, and future directions",
abstract = "Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was first described over a century ago, uncertainties and controversies remain regarding the contribution of reactive astrocytes to CNS diseases, repair, and aging. It is also unclear whether fixed categories of reactive astrocytes exist and, if so, how to identify them. We point out the shortcomings of binary divisions of reactive astrocytes into good-vs-bad, neurotoxic-vs-neuroprotective or A1-vs-A2. We advocate, instead, that research on reactive astrocytes include assessment of multiple molecular and functional parameters-preferably in vivo-plus multivariate statistics and determination of impact on pathological hallmarks in relevant models. These guidelines may spur the discovery of astrocyte-based biomarkers as well as astrocyte-targeting therapies that abrogate detrimental actions of reactive astrocytes, potentiate their neuro- and glioprotective actions, and restore or augment their homeostatic, modulatory, and defensive functions.Good-bad binary classifications fail to describe reactive astrocytes in CNS disorders. Here, 81 researchers reach consensus on widespread misconceptions and provide definitions and recommendations for future research on reactive astrocytes.",
author = "Carole Escartin and Elena Galea and Andras Lakatos and O'Callaghan, {James P.} and Petzold, {Gabor C.} and Alberto Serrano-Pozo and Christian Steinhauser and Andrea Volterra and Giorgio Carmignoto and Amit Agarwal and Allen, {Nicola J.} and Alfonso Araque and Luis Barbeito and Ari Barzilai and Bergles, {Dwight E.} and Gilles Bonvento and Butt, {Arthur M.} and Wei-Ting Chen and Martine Cohen-Salmon and Colm Cunningham and Benjamin Deneen and {De Strooper}, Bart and Blanca Diaz-Castro and Cinthia Farina and Marc Freeman and Vittorio Gallo and Goldman, {James E.} and Goldman, {Steven A.} and Magdalena Gotz and Antonia Gutierrez and Haydon, {Philip G.} and Heiland, {Dieter H.} and Hol, {Elly M.} and Holt, {Matthew G.} and Masamitsu Iino and Kastanenka, {Ksenia V.} and Helmut Kettenmann and Khakh, {Baljit S.} and Schuichi Koizumi and Lee, {C. Justin} and Liddelow, {Shane A.} and MacVicar, {Brian A.} and Pierre Magistretti and Albee Messing and Anusha Mishra and Molofsky, {Anna V.} and Murai, {Keith K.} and Norris, {Christopher M.} and Seiji Okada and Oliet, {Stephane H. R.} and Oliveira, {Joao F.} and Aude Panatier and Vladimir Parpura and Marcela Pekna and Milos Pekny and Luc Pellerin and Gertrudis Perea and Perez-Nievas, {Beatriz G.} and Pfrieger, {Frank W.} and Poskanzer, {Kira E.} and Quintana, {Francisco J.} and Ransohoff, {Richard M.} and Miriam Riquelme-Perez and Stefanie Robel and Rose, {Christine R.} and Rothstein, {Jeffrey D.} and Nathalie Rouach and Rowitch, {David H.} and Alexey Semyanov and Swetlana Sirko and Harald Sontheimer and Swanson, {Raymond A.} and Javier Vitorica and Ina-Beate Wanner and Wood, {Levi B.} and Jiaqian Wu and Binhai Zheng and Zimmer, {Eduardo R.} and Robert Zorec and Sofroniew, {Michael V.} and Alexei Verkhratsky",
year = "2021",
doi = "10.1038/s41593-020-00783-4",
language = "English",
volume = "24",
pages = "312–325",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Reactive astrocyte nomenclature, definitions, and future directions

AU - Escartin, Carole

AU - Galea, Elena

AU - Lakatos, Andras

AU - O'Callaghan, James P.

AU - Petzold, Gabor C.

AU - Serrano-Pozo, Alberto

AU - Steinhauser, Christian

AU - Volterra, Andrea

AU - Carmignoto, Giorgio

AU - Agarwal, Amit

AU - Allen, Nicola J.

AU - Araque, Alfonso

AU - Barbeito, Luis

AU - Barzilai, Ari

AU - Bergles, Dwight E.

AU - Bonvento, Gilles

AU - Butt, Arthur M.

AU - Chen, Wei-Ting

AU - Cohen-Salmon, Martine

AU - Cunningham, Colm

AU - Deneen, Benjamin

AU - De Strooper, Bart

AU - Diaz-Castro, Blanca

AU - Farina, Cinthia

AU - Freeman, Marc

AU - Gallo, Vittorio

AU - Goldman, James E.

AU - Goldman, Steven A.

AU - Gotz, Magdalena

AU - Gutierrez, Antonia

AU - Haydon, Philip G.

AU - Heiland, Dieter H.

AU - Hol, Elly M.

AU - Holt, Matthew G.

AU - Iino, Masamitsu

AU - Kastanenka, Ksenia V.

AU - Kettenmann, Helmut

AU - Khakh, Baljit S.

AU - Koizumi, Schuichi

AU - Lee, C. Justin

AU - Liddelow, Shane A.

AU - MacVicar, Brian A.

AU - Magistretti, Pierre

AU - Messing, Albee

AU - Mishra, Anusha

AU - Molofsky, Anna V.

AU - Murai, Keith K.

AU - Norris, Christopher M.

AU - Okada, Seiji

AU - Oliet, Stephane H. R.

AU - Oliveira, Joao F.

AU - Panatier, Aude

AU - Parpura, Vladimir

AU - Pekna, Marcela

AU - Pekny, Milos

AU - Pellerin, Luc

AU - Perea, Gertrudis

AU - Perez-Nievas, Beatriz G.

AU - Pfrieger, Frank W.

AU - Poskanzer, Kira E.

AU - Quintana, Francisco J.

AU - Ransohoff, Richard M.

AU - Riquelme-Perez, Miriam

AU - Robel, Stefanie

AU - Rose, Christine R.

AU - Rothstein, Jeffrey D.

AU - Rouach, Nathalie

AU - Rowitch, David H.

AU - Semyanov, Alexey

AU - Sirko, Swetlana

AU - Sontheimer, Harald

AU - Swanson, Raymond A.

AU - Vitorica, Javier

AU - Wanner, Ina-Beate

AU - Wood, Levi B.

AU - Wu, Jiaqian

AU - Zheng, Binhai

AU - Zimmer, Eduardo R.

AU - Zorec, Robert

AU - Sofroniew, Michael V.

AU - Verkhratsky, Alexei

PY - 2021

Y1 - 2021

N2 - Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was first described over a century ago, uncertainties and controversies remain regarding the contribution of reactive astrocytes to CNS diseases, repair, and aging. It is also unclear whether fixed categories of reactive astrocytes exist and, if so, how to identify them. We point out the shortcomings of binary divisions of reactive astrocytes into good-vs-bad, neurotoxic-vs-neuroprotective or A1-vs-A2. We advocate, instead, that research on reactive astrocytes include assessment of multiple molecular and functional parameters-preferably in vivo-plus multivariate statistics and determination of impact on pathological hallmarks in relevant models. These guidelines may spur the discovery of astrocyte-based biomarkers as well as astrocyte-targeting therapies that abrogate detrimental actions of reactive astrocytes, potentiate their neuro- and glioprotective actions, and restore or augment their homeostatic, modulatory, and defensive functions.Good-bad binary classifications fail to describe reactive astrocytes in CNS disorders. Here, 81 researchers reach consensus on widespread misconceptions and provide definitions and recommendations for future research on reactive astrocytes.

AB - Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was first described over a century ago, uncertainties and controversies remain regarding the contribution of reactive astrocytes to CNS diseases, repair, and aging. It is also unclear whether fixed categories of reactive astrocytes exist and, if so, how to identify them. We point out the shortcomings of binary divisions of reactive astrocytes into good-vs-bad, neurotoxic-vs-neuroprotective or A1-vs-A2. We advocate, instead, that research on reactive astrocytes include assessment of multiple molecular and functional parameters-preferably in vivo-plus multivariate statistics and determination of impact on pathological hallmarks in relevant models. These guidelines may spur the discovery of astrocyte-based biomarkers as well as astrocyte-targeting therapies that abrogate detrimental actions of reactive astrocytes, potentiate their neuro- and glioprotective actions, and restore or augment their homeostatic, modulatory, and defensive functions.Good-bad binary classifications fail to describe reactive astrocytes in CNS disorders. Here, 81 researchers reach consensus on widespread misconceptions and provide definitions and recommendations for future research on reactive astrocytes.

U2 - 10.1038/s41593-020-00783-4

DO - 10.1038/s41593-020-00783-4

M3 - Journal article

C2 - 33589835

VL - 24

SP - 312

EP - 325

JO - Nature Neuroscience

JF - Nature Neuroscience

SN - 1097-6256

ER -

ID: 257781932