Psilocybin-induced reduction in chronic cluster headache attack frequency correlates with changes in hypothalamic functional connectivity

Research output: Working paper › Preprint › Research

Standard

Psilocybin-induced reduction in chronic cluster headache attack frequency correlates with changes in hypothalamic functional connectivity. / Madsen, M. K.; Petersen, A. S.; Stenbaek, D. S.; Sorensen, I. M.; Schionning, H.; Fjeld, T.; Nykjaer, C.; Larsen, S. M. U.; Grzywacz, M.; Mathiesen, T.; Klausen, I.; Hansen, O. O.; Brendstrup-Brix, K.; Linnet, K.; Johansen, S. S.; Fisher, P. M.; Jensen, R. H.; Knudsen, G. M.; Madsen, M. K.

medRxiv, 2022.

Research output: Working paper › Preprint › Research

Harvard

Madsen, MK, Petersen, AS, Stenbaek, DS, Sorensen, IM, Schionning, H, Fjeld, T, Nykjaer, C, Larsen, SMU, Grzywacz, M, Mathiesen, T, Klausen, I, Hansen, OO, Brendstrup-Brix, K, Linnet, K, Johansen, SS, Fisher, PM, Jensen, RH, Knudsen, GM & Madsen, MK 2022 'Psilocybin-induced reduction in chronic cluster headache attack frequency correlates with changes in hypothalamic functional connectivity' medRxiv. https://doi.org/10.1101/2022.07.10.22277414

APA

Madsen, M. K., Petersen, A. S., Stenbaek, D. S., Sorensen, I. M., Schionning, H., Fjeld, T., Nykjaer, C., Larsen, S. M. U., Grzywacz, M., Mathiesen, T., Klausen, I., Hansen, O. O., Brendstrup-Brix, K., Linnet, K., Johansen, S. S., Fisher, P. M., Jensen, R. H., Knudsen, G. M., & Madsen, M. K. (2022). Psilocybin-induced reduction in chronic cluster headache attack frequency correlates with changes in hypothalamic functional connectivity. medRxiv. https://doi.org/10.1101/2022.07.10.22277414

Vancouver

Madsen MK, Petersen AS, Stenbaek DS, Sorensen IM, Schionning H, Fjeld T et al. Psilocybin-induced reduction in chronic cluster headache attack frequency correlates with changes in hypothalamic functional connectivity. medRxiv. 2022. https://doi.org/10.1101/2022.07.10.22277414

Author

Madsen, M. K. ; Petersen, A. S. ; Stenbaek, D. S. ; Sorensen, I. M. ; Schionning, H. ; Fjeld, T. ; Nykjaer, C. ; Larsen, S. M. U. ; Grzywacz, M. ; Mathiesen, T. ; Klausen, I. ; Hansen, O. O. ; Brendstrup-Brix, K. ; Linnet, K. ; Johansen, S. S. ; Fisher, P. M. ; Jensen, R. H. ; Knudsen, G. M. ; Madsen, M. K. / Psilocybin-induced reduction in chronic cluster headache attack frequency correlates with changes in hypothalamic functional connectivity. medRxiv, 2022.

Bibtex

@techreport{d2c3632ef3c74f16af7cc5b471e99a91,
title = "Psilocybin-induced reduction in chronic cluster headache attack frequency correlates with changes in hypothalamic functional connectivity",
abstract = "Chronic cluster headache (CCH) is an excruciating disorder of unknown pathophysiology, but hypothalamic dysfunction has been implicated. CCH is difficult to treat but on a case-basis, the psychedelic compound psilocybin is said to have beneficial effects. In this first-ever clinical trial (NCT04280055), we evaluate in a small open-label study of CCH patients the feasibility and prophylactic effect of three low-to-moderate doses of psilocybin as well as effects on hypothalamic functional connectivity (FC), using functional magnetic resonance imaging. The treatment was well-tolerated and without serious adverse reactions. Attack frequency was on average reduced by 30% from baseline to follow-up (PFWER=0.008). One patient experienced 21 weeks of complete remission. Changes in hypothalamic-diencephalic FC correlated negatively with relative reduction in attack frequency, implicating this neural pathway in treatment response. Further clinical studies are warranted to confirm the safety and prophylactic efficacy of psilocybin for CCH and hypothalamic involvement in treatment response.",
keywords = "neurology",
author = "Madsen, {M. K.} and Petersen, {A. S.} and Stenbaek, {D. S.} and Sorensen, {I. M.} and H. Schionning and T. Fjeld and C. Nykjaer and Larsen, {S. M. U.} and M. Grzywacz and T. Mathiesen and I. Klausen and Hansen, {O. O.} and K. Brendstrup-Brix and K. Linnet and Johansen, {S. S.} and Fisher, {P. M.} and Jensen, {R. H.} and Knudsen, {G. M.} and Madsen, {M. K.}",
year = "2022",
doi = "10.1101/2022.07.10.22277414",
language = "English",
publisher = "medRxiv",
type = "WorkingPaper",
institution = "medRxiv",

}

RIS

TY - UNPB

T1 - Psilocybin-induced reduction in chronic cluster headache attack frequency correlates with changes in hypothalamic functional connectivity

AU - Madsen, M. K.

AU - Petersen, A. S.

AU - Stenbaek, D. S.

AU - Sorensen, I. M.

AU - Schionning, H.

AU - Fjeld, T.

AU - Nykjaer, C.

AU - Larsen, S. M. U.

AU - Grzywacz, M.

AU - Mathiesen, T.

AU - Klausen, I.

AU - Hansen, O. O.

AU - Brendstrup-Brix, K.

AU - Linnet, K.

AU - Johansen, S. S.

AU - Fisher, P. M.

AU - Jensen, R. H.

AU - Knudsen, G. M.

AU - Madsen, M. K.

PY - 2022

Y1 - 2022

N2 - Chronic cluster headache (CCH) is an excruciating disorder of unknown pathophysiology, but hypothalamic dysfunction has been implicated. CCH is difficult to treat but on a case-basis, the psychedelic compound psilocybin is said to have beneficial effects. In this first-ever clinical trial (NCT04280055), we evaluate in a small open-label study of CCH patients the feasibility and prophylactic effect of three low-to-moderate doses of psilocybin as well as effects on hypothalamic functional connectivity (FC), using functional magnetic resonance imaging. The treatment was well-tolerated and without serious adverse reactions. Attack frequency was on average reduced by 30% from baseline to follow-up (PFWER=0.008). One patient experienced 21 weeks of complete remission. Changes in hypothalamic-diencephalic FC correlated negatively with relative reduction in attack frequency, implicating this neural pathway in treatment response. Further clinical studies are warranted to confirm the safety and prophylactic efficacy of psilocybin for CCH and hypothalamic involvement in treatment response.

AB - Chronic cluster headache (CCH) is an excruciating disorder of unknown pathophysiology, but hypothalamic dysfunction has been implicated. CCH is difficult to treat but on a case-basis, the psychedelic compound psilocybin is said to have beneficial effects. In this first-ever clinical trial (NCT04280055), we evaluate in a small open-label study of CCH patients the feasibility and prophylactic effect of three low-to-moderate doses of psilocybin as well as effects on hypothalamic functional connectivity (FC), using functional magnetic resonance imaging. The treatment was well-tolerated and without serious adverse reactions. Attack frequency was on average reduced by 30% from baseline to follow-up (PFWER=0.008). One patient experienced 21 weeks of complete remission. Changes in hypothalamic-diencephalic FC correlated negatively with relative reduction in attack frequency, implicating this neural pathway in treatment response. Further clinical studies are warranted to confirm the safety and prophylactic efficacy of psilocybin for CCH and hypothalamic involvement in treatment response.

KW - neurology

U2 - 10.1101/2022.07.10.22277414

DO - 10.1101/2022.07.10.22277414

M3 - Preprint

BT - Psilocybin-induced reduction in chronic cluster headache attack frequency correlates with changes in hypothalamic functional connectivity

PB - medRxiv

ER -

ID: 323976893