Physiology of Microglia

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Standard

Physiology of Microglia. / Garaschuk, Olga; Verkhratsky, Alexei.

Microglia: Methods and Protocols. ed. / Olga Garaschuk; Alexei Verkhratsky. Humana Press, 2019. p. 27-40 (Methods in Molecular Biology, Vol. 2034).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Harvard

Garaschuk, O & Verkhratsky, A 2019, Physiology of Microglia. in O Garaschuk & A Verkhratsky (eds), Microglia: Methods and Protocols. Humana Press, Methods in Molecular Biology, vol. 2034, pp. 27-40. https://doi.org/10.1007/978-1-4939-9658-2_3

APA

Garaschuk, O., & Verkhratsky, A. (2019). Physiology of Microglia. In O. Garaschuk, & A. Verkhratsky (Eds.), Microglia: Methods and Protocols (pp. 27-40). Humana Press. Methods in Molecular Biology Vol. 2034 https://doi.org/10.1007/978-1-4939-9658-2_3

Vancouver

Garaschuk O, Verkhratsky A. Physiology of Microglia. In Garaschuk O, Verkhratsky A, editors, Microglia: Methods and Protocols. Humana Press. 2019. p. 27-40. (Methods in Molecular Biology, Vol. 2034). https://doi.org/10.1007/978-1-4939-9658-2_3

Author

Garaschuk, Olga ; Verkhratsky, Alexei. / Physiology of Microglia. Microglia: Methods and Protocols. editor / Olga Garaschuk ; Alexei Verkhratsky. Humana Press, 2019. pp. 27-40 (Methods in Molecular Biology, Vol. 2034).

Bibtex

@inbook{5d4c85ef9c9e4e29bad9a4e2b3a187bb,
title = "Physiology of Microglia",
abstract = "Microglial cells derive from fetal macrophages which immigrate into and disseminate throughout the central nervous system (CNS) in early embryogenesis. After settling in the nerve tissue, microglial progenitors acquire an idiosyncratic morphological phenotype with small cell body and moving thin and highly ramified processes currently defined as “resting or surveillant microglia”. Physiology of microglia is manifested by second messenger-mediated cellular excitability, low resting membrane conductance, and expression of receptors to pathogen- or damage-associated molecular patterns (PAMPs and DAMPs), as well as receptors to classical neurotransmitters and neurohormones. This specific physiological profile reflects adaptive changes of myeloid cells to the CNS environment.",
keywords = "Chemokines, Cytokines, Damage-associated molecular patterns (DAMPs), Ion channels, Microglia, Neurotransmitter receptors, Pathogen-associated molecular patterns (PAMPs), Toll-like receptors (TLR)",
author = "Olga Garaschuk and Alexei Verkhratsky",
year = "2019",
doi = "10.1007/978-1-4939-9658-2_3",
language = "English",
isbn = "978-1-4939-9657-5",
series = "Methods in Molecular Biology",
publisher = "Humana Press",
pages = "27--40",
editor = "Olga Garaschuk and Alexei Verkhratsky",
booktitle = "Microglia",
address = "United States",

}

RIS

TY - CHAP

T1 - Physiology of Microglia

AU - Garaschuk, Olga

AU - Verkhratsky, Alexei

PY - 2019

Y1 - 2019

N2 - Microglial cells derive from fetal macrophages which immigrate into and disseminate throughout the central nervous system (CNS) in early embryogenesis. After settling in the nerve tissue, microglial progenitors acquire an idiosyncratic morphological phenotype with small cell body and moving thin and highly ramified processes currently defined as “resting or surveillant microglia”. Physiology of microglia is manifested by second messenger-mediated cellular excitability, low resting membrane conductance, and expression of receptors to pathogen- or damage-associated molecular patterns (PAMPs and DAMPs), as well as receptors to classical neurotransmitters and neurohormones. This specific physiological profile reflects adaptive changes of myeloid cells to the CNS environment.

AB - Microglial cells derive from fetal macrophages which immigrate into and disseminate throughout the central nervous system (CNS) in early embryogenesis. After settling in the nerve tissue, microglial progenitors acquire an idiosyncratic morphological phenotype with small cell body and moving thin and highly ramified processes currently defined as “resting or surveillant microglia”. Physiology of microglia is manifested by second messenger-mediated cellular excitability, low resting membrane conductance, and expression of receptors to pathogen- or damage-associated molecular patterns (PAMPs and DAMPs), as well as receptors to classical neurotransmitters and neurohormones. This specific physiological profile reflects adaptive changes of myeloid cells to the CNS environment.

KW - Chemokines

KW - Cytokines

KW - Damage-associated molecular patterns (DAMPs)

KW - Ion channels

KW - Microglia

KW - Neurotransmitter receptors

KW - Pathogen-associated molecular patterns (PAMPs)

KW - Toll-like receptors (TLR)

U2 - 10.1007/978-1-4939-9658-2_3

DO - 10.1007/978-1-4939-9658-2_3

M3 - Book chapter

C2 - 31392675

AN - SCOPUS:85071489602

SN - 978-1-4939-9657-5

T3 - Methods in Molecular Biology

SP - 27

EP - 40

BT - Microglia

A2 - Garaschuk, Olga

A2 - Verkhratsky, Alexei

PB - Humana Press

ER -

ID: 231243818