PDGF-B Is Required for Development of the Glymphatic System

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

PDGF-B Is Required for Development of the Glymphatic System. / Munk, Anne Sofie; Wang, Wei; Bèchet, Nicholas Burdon; Eltanahy, Ahmed M.; Cheng, Anne Xiaoan; Sigurdsson, Björn; Benraiss, Abdellatif; Mäe, Maarja A.; Kress, Benjamin Travis; Kelley, Douglas H.; Betsholtz, Christer; Møllgård, Kjeld; Meissner, Anja; Nedergaard, Maiken; Lundgaard, Iben.

In: Cell Reports, Vol. 26, No. 11, 2019, p. 2955-2969.e3.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Munk, AS, Wang, W, Bèchet, NB, Eltanahy, AM, Cheng, AX, Sigurdsson, B, Benraiss, A, Mäe, MA, Kress, BT, Kelley, DH, Betsholtz, C, Møllgård, K, Meissner, A, Nedergaard, M & Lundgaard, I 2019, 'PDGF-B Is Required for Development of the Glymphatic System', Cell Reports, vol. 26, no. 11, pp. 2955-2969.e3. https://doi.org/10.1016/j.celrep.2019.02.050

APA

Munk, A. S., Wang, W., Bèchet, N. B., Eltanahy, A. M., Cheng, A. X., Sigurdsson, B., Benraiss, A., Mäe, M. A., Kress, B. T., Kelley, D. H., Betsholtz, C., Møllgård, K., Meissner, A., Nedergaard, M., & Lundgaard, I. (2019). PDGF-B Is Required for Development of the Glymphatic System. Cell Reports, 26(11), 2955-2969.e3. https://doi.org/10.1016/j.celrep.2019.02.050

Vancouver

Munk AS, Wang W, Bèchet NB, Eltanahy AM, Cheng AX, Sigurdsson B et al. PDGF-B Is Required for Development of the Glymphatic System. Cell Reports. 2019;26(11):2955-2969.e3. https://doi.org/10.1016/j.celrep.2019.02.050

Author

Munk, Anne Sofie ; Wang, Wei ; Bèchet, Nicholas Burdon ; Eltanahy, Ahmed M. ; Cheng, Anne Xiaoan ; Sigurdsson, Björn ; Benraiss, Abdellatif ; Mäe, Maarja A. ; Kress, Benjamin Travis ; Kelley, Douglas H. ; Betsholtz, Christer ; Møllgård, Kjeld ; Meissner, Anja ; Nedergaard, Maiken ; Lundgaard, Iben. / PDGF-B Is Required for Development of the Glymphatic System. In: Cell Reports. 2019 ; Vol. 26, No. 11. pp. 2955-2969.e3.

Bibtex

@article{f77a4d4e7f6647bdba4a47a7f7bc08a0,
title = "PDGF-B Is Required for Development of the Glymphatic System",
abstract = " The glymphatic system is a highly polarized cerebrospinal fluid (CSF) transport system that facilitates the clearance of neurotoxic molecules through a brain-wide network of perivascular pathways. Herein we have mapped the development of the glymphatic system in mice. Perivascular CSF transport first emerges in hippocampus in newborn mice, and a mature glymphatic system is established in the cortex at 2 weeks of age. Formation of astrocytic endfeet and polarized expression of aquaporin 4 (AQP4) consistently coincided with the appearance of perivascular CSF transport. Deficiency of platelet-derived growth factor B (PDGF-B) function in the PDGF retention motif knockout mouse line Pdgfb ret/ret suppressed the development of the glymphatic system, whose functions remained suppressed in adulthood compared with wild-type mice. These experiments map the natural development of the glymphatic system in mice and define a critical role of PDGF-B in the development of perivascular CSF transport. ",
keywords = "aquaporin 4, astrocytes, cerebrospinal fluid, glymphatic system, platelet-derived growth factor B, postnatal development",
author = "Munk, {Anne Sofie} and Wei Wang and B{\`e}chet, {Nicholas Burdon} and Eltanahy, {Ahmed M.} and Cheng, {Anne Xiaoan} and Bj{\"o}rn Sigurdsson and Abdellatif Benraiss and M{\"a}e, {Maarja A.} and Kress, {Benjamin Travis} and Kelley, {Douglas H.} and Christer Betsholtz and Kjeld M{\o}llg{\aa}rd and Anja Meissner and Maiken Nedergaard and Iben Lundgaard",
year = "2019",
doi = "10.1016/j.celrep.2019.02.050",
language = "English",
volume = "26",
pages = "2955--2969.e3",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "11",

}

RIS

TY - JOUR

T1 - PDGF-B Is Required for Development of the Glymphatic System

AU - Munk, Anne Sofie

AU - Wang, Wei

AU - Bèchet, Nicholas Burdon

AU - Eltanahy, Ahmed M.

AU - Cheng, Anne Xiaoan

AU - Sigurdsson, Björn

AU - Benraiss, Abdellatif

AU - Mäe, Maarja A.

AU - Kress, Benjamin Travis

AU - Kelley, Douglas H.

AU - Betsholtz, Christer

AU - Møllgård, Kjeld

AU - Meissner, Anja

AU - Nedergaard, Maiken

AU - Lundgaard, Iben

PY - 2019

Y1 - 2019

N2 - The glymphatic system is a highly polarized cerebrospinal fluid (CSF) transport system that facilitates the clearance of neurotoxic molecules through a brain-wide network of perivascular pathways. Herein we have mapped the development of the glymphatic system in mice. Perivascular CSF transport first emerges in hippocampus in newborn mice, and a mature glymphatic system is established in the cortex at 2 weeks of age. Formation of astrocytic endfeet and polarized expression of aquaporin 4 (AQP4) consistently coincided with the appearance of perivascular CSF transport. Deficiency of platelet-derived growth factor B (PDGF-B) function in the PDGF retention motif knockout mouse line Pdgfb ret/ret suppressed the development of the glymphatic system, whose functions remained suppressed in adulthood compared with wild-type mice. These experiments map the natural development of the glymphatic system in mice and define a critical role of PDGF-B in the development of perivascular CSF transport.

AB - The glymphatic system is a highly polarized cerebrospinal fluid (CSF) transport system that facilitates the clearance of neurotoxic molecules through a brain-wide network of perivascular pathways. Herein we have mapped the development of the glymphatic system in mice. Perivascular CSF transport first emerges in hippocampus in newborn mice, and a mature glymphatic system is established in the cortex at 2 weeks of age. Formation of astrocytic endfeet and polarized expression of aquaporin 4 (AQP4) consistently coincided with the appearance of perivascular CSF transport. Deficiency of platelet-derived growth factor B (PDGF-B) function in the PDGF retention motif knockout mouse line Pdgfb ret/ret suppressed the development of the glymphatic system, whose functions remained suppressed in adulthood compared with wild-type mice. These experiments map the natural development of the glymphatic system in mice and define a critical role of PDGF-B in the development of perivascular CSF transport.

KW - aquaporin 4

KW - astrocytes

KW - cerebrospinal fluid

KW - glymphatic system

KW - platelet-derived growth factor B

KW - postnatal development

U2 - 10.1016/j.celrep.2019.02.050

DO - 10.1016/j.celrep.2019.02.050

M3 - Journal article

C2 - 30865886

AN - SCOPUS:85062401630

VL - 26

SP - 2955-2969.e3

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 11

ER -

ID: 216866106