NMDA Receptors in Astrocytes
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NMDA Receptors in Astrocytes. / Verkhratsky, Alexei; Chvátal, Alexandr.
In: Neurochemical Research, Vol. 45, No. 1, 2020, p. 123-133.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - NMDA Receptors in Astrocytes
AU - Verkhratsky, Alexei
AU - Chvátal, Alexandr
PY - 2020
Y1 - 2020
N2 - Astrocytes support glutamatergic neurotransmission in the central nervous system through multiple mechanisms which include: (i) glutamate clearance and control over glutamate spillover due to operation of glutamate transporters; (ii) supply of obligatory glutamate precursor glutamine via operation of glutamate–glutamine shuttle; (iii) supply of l-serine, the indispensable precursor of positive NMDA receptors neuromodulator d-serine and (iv) through overall homoeostatic control of the synaptic cleft. Astroglial cells express an extended complement of ionotropic and metabotropic glutamate receptors, which mediate glutamatergic input to astrocytes. In particular a sub-population of astrocytes in the cortex and in the spinal cord express specific type of NMDA receptors assembled from two GluN1, one GluN2C or D and one GluN3 subunits. This composition underlies low Mg 2+ sensitivity thus making astroglial NMDA receptors operational at resting membrane potential. These NMDA receptors generate ionic signals in astrocytes and are linked to several astroglial homoeostatic molecular cascades.
AB - Astrocytes support glutamatergic neurotransmission in the central nervous system through multiple mechanisms which include: (i) glutamate clearance and control over glutamate spillover due to operation of glutamate transporters; (ii) supply of obligatory glutamate precursor glutamine via operation of glutamate–glutamine shuttle; (iii) supply of l-serine, the indispensable precursor of positive NMDA receptors neuromodulator d-serine and (iv) through overall homoeostatic control of the synaptic cleft. Astroglial cells express an extended complement of ionotropic and metabotropic glutamate receptors, which mediate glutamatergic input to astrocytes. In particular a sub-population of astrocytes in the cortex and in the spinal cord express specific type of NMDA receptors assembled from two GluN1, one GluN2C or D and one GluN3 subunits. This composition underlies low Mg 2+ sensitivity thus making astroglial NMDA receptors operational at resting membrane potential. These NMDA receptors generate ionic signals in astrocytes and are linked to several astroglial homoeostatic molecular cascades.
KW - Astrocyte
KW - Glutamate
KW - Neurotransmitters
KW - NMDA receptors
U2 - 10.1007/s11064-019-02750-3
DO - 10.1007/s11064-019-02750-3
M3 - Journal article
C2 - 30767094
AN - SCOPUS:85061567851
VL - 45
SP - 123
EP - 133
JO - Neurochemical Research
JF - Neurochemical Research
SN - 0364-3190
IS - 1
ER -
ID: 226262060