Neuroglia in ageing
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Neuroglia in ageing. / Verkhratsky, Alexei; Zorec, Robert; Rodriguez-Arellano, Jose Julio; Parpura, Vladimir.
Neuroglia in Neurodegenerative Diseases. ed. / Alexei Verkhratsky; Margaret S. Ho; Robert Zorec; Vladimir Parpura. Springer, 2019. p. 181-197 (Advances in Experimental Medicine and Biology, Vol. 1175).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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TY - CHAP
T1 - Neuroglia in ageing
AU - Verkhratsky, Alexei
AU - Zorec, Robert
AU - Rodriguez-Arellano, Jose Julio
AU - Parpura, Vladimir
PY - 2019
Y1 - 2019
N2 - Ageing reduces the functional capacity of all organs, so does that of the nervous system; the latter is evident in the reduction of cognitive abilities, learning and memory. While the exact mechanisms of ageing of the nervous system remain elusive, it is without doubt that morpho-functional changes in a variety of neuroglial cells contribute to this process. The age-dependent changes in neuroglia are characterised by a progressive loss of function. This reduces glial ability to homeostatically nurture, protect and regenerate the nervous tissue. Such neuroglial paralysis also facilitates neurodegenerative processes. Ageing of neuroglia is variable and can be affected by environmental factors and comorbidities.
AB - Ageing reduces the functional capacity of all organs, so does that of the nervous system; the latter is evident in the reduction of cognitive abilities, learning and memory. While the exact mechanisms of ageing of the nervous system remain elusive, it is without doubt that morpho-functional changes in a variety of neuroglial cells contribute to this process. The age-dependent changes in neuroglia are characterised by a progressive loss of function. This reduces glial ability to homeostatically nurture, protect and regenerate the nervous tissue. Such neuroglial paralysis also facilitates neurodegenerative processes. Ageing of neuroglia is variable and can be affected by environmental factors and comorbidities.
KW - Ageing
KW - Astrocyte
KW - Microglia
KW - NG2 cells
KW - Oligodendrocytes
U2 - 10.1007/978-981-13-9913-8_8
DO - 10.1007/978-981-13-9913-8_8
M3 - Book chapter
C2 - 31583589
AN - SCOPUS:85072926833
SN - 978-981-13-9912-1
T3 - Advances in Experimental Medicine and Biology
SP - 181
EP - 197
BT - Neuroglia in Neurodegenerative Diseases
A2 - Verkhratsky, Alexei
A2 - Ho, Margaret S.
A2 - Zorec, Robert
A2 - Parpura, Vladimir
PB - Springer
ER -
ID: 231243086