Microglia: The Neural Cells of Nonneural Origin

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Standard

Microglia : The Neural Cells of Nonneural Origin. / Garaschuk, Olga; Verkhratsky, Alexei.

Microglia: Methods and Protocols. ed. / Olga Garaschuk; Alexei Verkhratsky. Humana Press, 2019. p. 3-11 (Methods in Molecular Biology, Vol. 2034).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Harvard

Garaschuk, O & Verkhratsky, A 2019, Microglia: The Neural Cells of Nonneural Origin. in O Garaschuk & A Verkhratsky (eds), Microglia: Methods and Protocols. Humana Press, Methods in Molecular Biology, vol. 2034, pp. 3-11. https://doi.org/10.1007/978-1-4939-9658-2_1

APA

Garaschuk, O., & Verkhratsky, A. (2019). Microglia: The Neural Cells of Nonneural Origin. In O. Garaschuk, & A. Verkhratsky (Eds.), Microglia: Methods and Protocols (pp. 3-11). Humana Press. Methods in Molecular Biology Vol. 2034 https://doi.org/10.1007/978-1-4939-9658-2_1

Vancouver

Garaschuk O, Verkhratsky A. Microglia: The Neural Cells of Nonneural Origin. In Garaschuk O, Verkhratsky A, editors, Microglia: Methods and Protocols. Humana Press. 2019. p. 3-11. (Methods in Molecular Biology, Vol. 2034). https://doi.org/10.1007/978-1-4939-9658-2_1

Author

Garaschuk, Olga ; Verkhratsky, Alexei. / Microglia : The Neural Cells of Nonneural Origin. Microglia: Methods and Protocols. editor / Olga Garaschuk ; Alexei Verkhratsky. Humana Press, 2019. pp. 3-11 (Methods in Molecular Biology, Vol. 2034).

Bibtex

@inbook{6f6044aab8d747a79c76fb10f0d2e43c,
title = "Microglia: The Neural Cells of Nonneural Origin",
abstract = "Microglia are neural cells of nonneural origin; they originate from fetal macrophages that invade neural tube early in embryogenesis and undergo the most idiosyncratic metamorphosis which coverts them into elements of neural circuitry. Microglia appeared early in evolution with neural immune cells being operative in leeches and mollusks. Microglial cells acquire specific morphology characterized by small cell bodies and long motile processes which are packed with receptors sensing both physiological and pathological stimuli. Microglial cells actively sculpture neuronal networks through synaptic stripping and phagocytosis of redundant neurons; microglia also secrete neuroactive factors regulating synaptic transmission. Novel techniques emerging in recent decade allowed an in-depth understanding of physiological and pathophysiological functions of microglia.",
keywords = "CNS invasion, Development, Evolution, Microglia, Neurogenesis, Signaling pathways, Synaptic stripping, Synaptogenesis",
author = "Olga Garaschuk and Alexei Verkhratsky",
year = "2019",
doi = "10.1007/978-1-4939-9658-2_1",
language = "English",
isbn = "978-1-4939-9657-5",
series = "Methods in Molecular Biology",
publisher = "Humana Press",
pages = "3--11",
editor = "Olga Garaschuk and Alexei Verkhratsky",
booktitle = "Microglia",
address = "United States",

}

RIS

TY - CHAP

T1 - Microglia

T2 - The Neural Cells of Nonneural Origin

AU - Garaschuk, Olga

AU - Verkhratsky, Alexei

PY - 2019

Y1 - 2019

N2 - Microglia are neural cells of nonneural origin; they originate from fetal macrophages that invade neural tube early in embryogenesis and undergo the most idiosyncratic metamorphosis which coverts them into elements of neural circuitry. Microglia appeared early in evolution with neural immune cells being operative in leeches and mollusks. Microglial cells acquire specific morphology characterized by small cell bodies and long motile processes which are packed with receptors sensing both physiological and pathological stimuli. Microglial cells actively sculpture neuronal networks through synaptic stripping and phagocytosis of redundant neurons; microglia also secrete neuroactive factors regulating synaptic transmission. Novel techniques emerging in recent decade allowed an in-depth understanding of physiological and pathophysiological functions of microglia.

AB - Microglia are neural cells of nonneural origin; they originate from fetal macrophages that invade neural tube early in embryogenesis and undergo the most idiosyncratic metamorphosis which coverts them into elements of neural circuitry. Microglia appeared early in evolution with neural immune cells being operative in leeches and mollusks. Microglial cells acquire specific morphology characterized by small cell bodies and long motile processes which are packed with receptors sensing both physiological and pathological stimuli. Microglial cells actively sculpture neuronal networks through synaptic stripping and phagocytosis of redundant neurons; microglia also secrete neuroactive factors regulating synaptic transmission. Novel techniques emerging in recent decade allowed an in-depth understanding of physiological and pathophysiological functions of microglia.

KW - CNS invasion

KW - Development

KW - Evolution

KW - Microglia

KW - Neurogenesis

KW - Signaling pathways

KW - Synaptic stripping

KW - Synaptogenesis

U2 - 10.1007/978-1-4939-9658-2_1

DO - 10.1007/978-1-4939-9658-2_1

M3 - Book chapter

C2 - 31392673

AN - SCOPUS:85071494525

SN - 978-1-4939-9657-5

T3 - Methods in Molecular Biology

SP - 3

EP - 11

BT - Microglia

A2 - Garaschuk, Olga

A2 - Verkhratsky, Alexei

PB - Humana Press

ER -

ID: 231242757