Loss of calretinin and parvalbumin positive interneurones in the hippocampal CA1 of aged Alzheimer's disease mice

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Loss of calretinin and parvalbumin positive interneurones in the hippocampal CA1 of aged Alzheimer's disease mice. / Zallo, Fatima; Gardenal, Emanuela; Verkhratsky, Alexei; Rodríguez, José Julio.

In: Neuroscience Letters, Vol. 681, 2018, p. 19-25.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Zallo, F, Gardenal, E, Verkhratsky, A & Rodríguez, JJ 2018, 'Loss of calretinin and parvalbumin positive interneurones in the hippocampal CA1 of aged Alzheimer's disease mice', Neuroscience Letters, vol. 681, pp. 19-25. https://doi.org/10.1016/j.neulet.2018.05.027

APA

Zallo, F., Gardenal, E., Verkhratsky, A., & Rodríguez, J. J. (2018). Loss of calretinin and parvalbumin positive interneurones in the hippocampal CA1 of aged Alzheimer's disease mice. Neuroscience Letters, 681, 19-25. https://doi.org/10.1016/j.neulet.2018.05.027

Vancouver

Zallo F, Gardenal E, Verkhratsky A, Rodríguez JJ. Loss of calretinin and parvalbumin positive interneurones in the hippocampal CA1 of aged Alzheimer's disease mice. Neuroscience Letters. 2018;681:19-25. https://doi.org/10.1016/j.neulet.2018.05.027

Author

Zallo, Fatima ; Gardenal, Emanuela ; Verkhratsky, Alexei ; Rodríguez, José Julio. / Loss of calretinin and parvalbumin positive interneurones in the hippocampal CA1 of aged Alzheimer's disease mice. In: Neuroscience Letters. 2018 ; Vol. 681. pp. 19-25.

Bibtex

@article{971aa97196954ed1ac20ccd048b3f05b,
title = "Loss of calretinin and parvalbumin positive interneurones in the hippocampal CA1 of aged Alzheimer's disease mice",
abstract = "Neuronal degeneration associated with Alzheimer's disease (AD), is linked to impaired calcium homeostasis and to changes in calcium-binding proteins (CBPs). The AD-related modification of neuronal CBPs remains controversial. Here we analysed the presence and expression of calretinin (CR) and parvalbumin (PV) in the hippocampal CA1 neurones of 18 months old 3xTg-AD mice compared to non-Tg animals. We found a layer specific decrease in number of interneurones expressing CR and PV (by 33.7% and 52%, respectively). Expression of PV decreased (by 13.8%) in PV-positive neurones, whereas expression of CR did not change in CR positive cells. The loss of specific subpopulations of Ca2+-binding proteins expressing interneurones (CR and PV) together with the decrease of PV in the surviving cells may be linked to their vulnerability to AD pathology. Specific loss of inhibitory interneurones with age could contribute to overall increase in the network excitability associated with AD.",
keywords = "Alzheimer's disease, CA1, Calretinin, Hippocampus, Parvalbumin",
author = "Fatima Zallo and Emanuela Gardenal and Alexei Verkhratsky and Rodr{\'i}guez, {Jos{\'e} Julio}",
year = "2018",
doi = "10.1016/j.neulet.2018.05.027",
language = "English",
volume = "681",
pages = "19--25",
journal = "Neuroscience letters. Supplement",
issn = "0167-6253",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Loss of calretinin and parvalbumin positive interneurones in the hippocampal CA1 of aged Alzheimer's disease mice

AU - Zallo, Fatima

AU - Gardenal, Emanuela

AU - Verkhratsky, Alexei

AU - Rodríguez, José Julio

PY - 2018

Y1 - 2018

N2 - Neuronal degeneration associated with Alzheimer's disease (AD), is linked to impaired calcium homeostasis and to changes in calcium-binding proteins (CBPs). The AD-related modification of neuronal CBPs remains controversial. Here we analysed the presence and expression of calretinin (CR) and parvalbumin (PV) in the hippocampal CA1 neurones of 18 months old 3xTg-AD mice compared to non-Tg animals. We found a layer specific decrease in number of interneurones expressing CR and PV (by 33.7% and 52%, respectively). Expression of PV decreased (by 13.8%) in PV-positive neurones, whereas expression of CR did not change in CR positive cells. The loss of specific subpopulations of Ca2+-binding proteins expressing interneurones (CR and PV) together with the decrease of PV in the surviving cells may be linked to their vulnerability to AD pathology. Specific loss of inhibitory interneurones with age could contribute to overall increase in the network excitability associated with AD.

AB - Neuronal degeneration associated with Alzheimer's disease (AD), is linked to impaired calcium homeostasis and to changes in calcium-binding proteins (CBPs). The AD-related modification of neuronal CBPs remains controversial. Here we analysed the presence and expression of calretinin (CR) and parvalbumin (PV) in the hippocampal CA1 neurones of 18 months old 3xTg-AD mice compared to non-Tg animals. We found a layer specific decrease in number of interneurones expressing CR and PV (by 33.7% and 52%, respectively). Expression of PV decreased (by 13.8%) in PV-positive neurones, whereas expression of CR did not change in CR positive cells. The loss of specific subpopulations of Ca2+-binding proteins expressing interneurones (CR and PV) together with the decrease of PV in the surviving cells may be linked to their vulnerability to AD pathology. Specific loss of inhibitory interneurones with age could contribute to overall increase in the network excitability associated with AD.

KW - Alzheimer's disease

KW - CA1

KW - Calretinin

KW - Hippocampus

KW - Parvalbumin

U2 - 10.1016/j.neulet.2018.05.027

DO - 10.1016/j.neulet.2018.05.027

M3 - Journal article

C2 - 29782955

AN - SCOPUS:85047379463

VL - 681

SP - 19

EP - 25

JO - Neuroscience letters. Supplement

JF - Neuroscience letters. Supplement

SN - 0167-6253

ER -

ID: 209802932