Ionic signalling in astroglia beyond calcium

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Ionic signalling in astroglia beyond calcium. / Verkhratsky, Alexei; Untiet, Verena; Rose, Christine R.

In: The Journal of Physiology, Vol. 598, No. 9, 2020, p. 1655-1670.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Verkhratsky, A, Untiet, V & Rose, CR 2020, 'Ionic signalling in astroglia beyond calcium', The Journal of Physiology, vol. 598, no. 9, pp. 1655-1670. https://doi.org/10.1113/JP277478

APA

Verkhratsky, A., Untiet, V., & Rose, C. R. (2020). Ionic signalling in astroglia beyond calcium. The Journal of Physiology, 598(9), 1655-1670. https://doi.org/10.1113/JP277478

Vancouver

Verkhratsky A, Untiet V, Rose CR. Ionic signalling in astroglia beyond calcium. The Journal of Physiology. 2020;598(9):1655-1670. https://doi.org/10.1113/JP277478

Author

Verkhratsky, Alexei ; Untiet, Verena ; Rose, Christine R. / Ionic signalling in astroglia beyond calcium. In: The Journal of Physiology. 2020 ; Vol. 598, No. 9. pp. 1655-1670.

Bibtex

@article{fdc1e29eb96e489db233d789993c958a,
title = "Ionic signalling in astroglia beyond calcium",
abstract = " Astrocytes are homeostatic and protective cells of the central nervous system. Astroglial homeostatic responses are tightly coordinated with neuronal activity. Astrocytes maintain neuronal excitability through regulation of extracellular ion concentrations, as well as assisting and modulating synaptic transmission by uptake and catabolism of major neurotransmitters. Moreover, they support neuronal metabolism and detoxify ammonium and reactive oxygen species. Astroglial homeostatic actions are initiated and controlled by intercellular signalling of ions, including Ca 2+ , Na + , Cl − , H + and possibly K + . This review summarises current knowledge on ionic signals mediated by the major monovalent ions, which occur in microdomains, as global events, or as propagating intercellular waves and thereby represent the substrate for astroglial excitability. (Figure presented.). ",
keywords = "Astrocytes, Cl signalling, H homeostasis, K homoeostasis, Na signalling",
author = "Alexei Verkhratsky and Verena Untiet and Rose, {Christine R.}",
year = "2020",
doi = "10.1113/JP277478",
language = "English",
volume = "598",
pages = "1655--1670",
journal = "The Journal of Physiology",
issn = "0022-3751",
publisher = "Wiley-Blackwell",
number = "9",

}

RIS

TY - JOUR

T1 - Ionic signalling in astroglia beyond calcium

AU - Verkhratsky, Alexei

AU - Untiet, Verena

AU - Rose, Christine R.

PY - 2020

Y1 - 2020

N2 - Astrocytes are homeostatic and protective cells of the central nervous system. Astroglial homeostatic responses are tightly coordinated with neuronal activity. Astrocytes maintain neuronal excitability through regulation of extracellular ion concentrations, as well as assisting and modulating synaptic transmission by uptake and catabolism of major neurotransmitters. Moreover, they support neuronal metabolism and detoxify ammonium and reactive oxygen species. Astroglial homeostatic actions are initiated and controlled by intercellular signalling of ions, including Ca 2+ , Na + , Cl − , H + and possibly K + . This review summarises current knowledge on ionic signals mediated by the major monovalent ions, which occur in microdomains, as global events, or as propagating intercellular waves and thereby represent the substrate for astroglial excitability. (Figure presented.).

AB - Astrocytes are homeostatic and protective cells of the central nervous system. Astroglial homeostatic responses are tightly coordinated with neuronal activity. Astrocytes maintain neuronal excitability through regulation of extracellular ion concentrations, as well as assisting and modulating synaptic transmission by uptake and catabolism of major neurotransmitters. Moreover, they support neuronal metabolism and detoxify ammonium and reactive oxygen species. Astroglial homeostatic actions are initiated and controlled by intercellular signalling of ions, including Ca 2+ , Na + , Cl − , H + and possibly K + . This review summarises current knowledge on ionic signals mediated by the major monovalent ions, which occur in microdomains, as global events, or as propagating intercellular waves and thereby represent the substrate for astroglial excitability. (Figure presented.).

KW - Astrocytes

KW - Cl signalling

KW - H homeostasis

KW - K homoeostasis

KW - Na signalling

U2 - 10.1113/JP277478

DO - 10.1113/JP277478

M3 - Review

C2 - 30734296

AN - SCOPUS:85062593885

VL - 598

SP - 1655

EP - 1670

JO - The Journal of Physiology

JF - The Journal of Physiology

SN - 0022-3751

IS - 9

ER -

ID: 226261899