Human iPSC-derived neural precursor cells differentiate into multiple cell types to delay disease progression following transplantation into YAC128 Huntington's disease mouse model

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Human iPSC-derived neural precursor cells differentiate into multiple cell types to delay disease progression following transplantation into YAC128 Huntington's disease mouse model. / Park, Hyun Jung; Jeon, Juhyun; Choi, Jiwoo; Kim, Ji Yeon; Kim, Hyun Sook; Huh, Ji Young; Goldman, Steven A.; Song, Jihwan.

In: Cell Proliferation, Vol. 54, No. 8, e13082, 2021.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Park, HJ, Jeon, J, Choi, J, Kim, JY, Kim, HS, Huh, JY, Goldman, SA & Song, J 2021, 'Human iPSC-derived neural precursor cells differentiate into multiple cell types to delay disease progression following transplantation into YAC128 Huntington's disease mouse model', Cell Proliferation, vol. 54, no. 8, e13082. https://doi.org/10.1111/cpr.13082

APA

Park, H. J., Jeon, J., Choi, J., Kim, J. Y., Kim, H. S., Huh, J. Y., Goldman, S. A., & Song, J. (2021). Human iPSC-derived neural precursor cells differentiate into multiple cell types to delay disease progression following transplantation into YAC128 Huntington's disease mouse model. Cell Proliferation, 54(8), [e13082]. https://doi.org/10.1111/cpr.13082

Vancouver

Park HJ, Jeon J, Choi J, Kim JY, Kim HS, Huh JY et al. Human iPSC-derived neural precursor cells differentiate into multiple cell types to delay disease progression following transplantation into YAC128 Huntington's disease mouse model. Cell Proliferation. 2021;54(8). e13082. https://doi.org/10.1111/cpr.13082

Author

Park, Hyun Jung ; Jeon, Juhyun ; Choi, Jiwoo ; Kim, Ji Yeon ; Kim, Hyun Sook ; Huh, Ji Young ; Goldman, Steven A. ; Song, Jihwan. / Human iPSC-derived neural precursor cells differentiate into multiple cell types to delay disease progression following transplantation into YAC128 Huntington's disease mouse model. In: Cell Proliferation. 2021 ; Vol. 54, No. 8.

Bibtex

@article{56056885f62c41b3897650c38cd4838c,
title = "Human iPSC-derived neural precursor cells differentiate into multiple cell types to delay disease progression following transplantation into YAC128 Huntington's disease mouse model",
abstract = "Objectives: To investigate whether human HLA-homozygous induced pluripotent stem cell (iPSC)-derived neural precursor cells (iPSC-NPCs) can provide functional benefits in Huntington{\textquoteright}s disease (HD), we transplanted them into the YAC128 transgenic HD mouse model. Materials and Methods: CHAi001-A, an HLA-homozygous iPSC line (A*33:03-B*44:03-DRB1*13:02), was differentiated into neural precursor cells, and then, they were transplanted into 6 months-old YAC128 mice. Various behavioural and histological analyses were performed for five months after transplantation. Results: Motor and cognitive functions were significantly improved in transplanted animals. Cells transplanted in the striatum showed multipotential differentiation. Five months after transplantation, the donor cells had differentiated into neurons, oligodendrocytes and astrocytes. Transplantation restored DARPP-32 expression, synaptophysin density, myelin basic protein expression in the corpus callosum and astrocyte function. Conclusion: Altogether, these results strongly suggest that iPSC-NPCs transplantation induces neuroprotection and functional recovery in a mouse model of HD and should be taken forward for clinical trials in HD patients.",
keywords = "astrocyte, functional recovery, glutamate toxicity, human leukocyte antigen (HLA), Huntington{\textquoteright}s disease (HD), induced pluripotent stem cell-derived neural precursor cells (iPSC-NPCs), inflammation",
author = "Park, {Hyun Jung} and Juhyun Jeon and Jiwoo Choi and Kim, {Ji Yeon} and Kim, {Hyun Sook} and Huh, {Ji Young} and Goldman, {Steven A.} and Jihwan Song",
note = "Publisher Copyright: {\textcopyright} 2021 The Authors. Cell Proliferation Published by John Wiley & Sons Ltd.",
year = "2021",
doi = "10.1111/cpr.13082",
language = "English",
volume = "54",
journal = "Cell Proliferation",
issn = "0960-7722",
publisher = "Wiley-Blackwell",
number = "8",

}

RIS

TY - JOUR

T1 - Human iPSC-derived neural precursor cells differentiate into multiple cell types to delay disease progression following transplantation into YAC128 Huntington's disease mouse model

AU - Park, Hyun Jung

AU - Jeon, Juhyun

AU - Choi, Jiwoo

AU - Kim, Ji Yeon

AU - Kim, Hyun Sook

AU - Huh, Ji Young

AU - Goldman, Steven A.

AU - Song, Jihwan

N1 - Publisher Copyright: © 2021 The Authors. Cell Proliferation Published by John Wiley & Sons Ltd.

PY - 2021

Y1 - 2021

N2 - Objectives: To investigate whether human HLA-homozygous induced pluripotent stem cell (iPSC)-derived neural precursor cells (iPSC-NPCs) can provide functional benefits in Huntington’s disease (HD), we transplanted them into the YAC128 transgenic HD mouse model. Materials and Methods: CHAi001-A, an HLA-homozygous iPSC line (A*33:03-B*44:03-DRB1*13:02), was differentiated into neural precursor cells, and then, they were transplanted into 6 months-old YAC128 mice. Various behavioural and histological analyses were performed for five months after transplantation. Results: Motor and cognitive functions were significantly improved in transplanted animals. Cells transplanted in the striatum showed multipotential differentiation. Five months after transplantation, the donor cells had differentiated into neurons, oligodendrocytes and astrocytes. Transplantation restored DARPP-32 expression, synaptophysin density, myelin basic protein expression in the corpus callosum and astrocyte function. Conclusion: Altogether, these results strongly suggest that iPSC-NPCs transplantation induces neuroprotection and functional recovery in a mouse model of HD and should be taken forward for clinical trials in HD patients.

AB - Objectives: To investigate whether human HLA-homozygous induced pluripotent stem cell (iPSC)-derived neural precursor cells (iPSC-NPCs) can provide functional benefits in Huntington’s disease (HD), we transplanted them into the YAC128 transgenic HD mouse model. Materials and Methods: CHAi001-A, an HLA-homozygous iPSC line (A*33:03-B*44:03-DRB1*13:02), was differentiated into neural precursor cells, and then, they were transplanted into 6 months-old YAC128 mice. Various behavioural and histological analyses were performed for five months after transplantation. Results: Motor and cognitive functions were significantly improved in transplanted animals. Cells transplanted in the striatum showed multipotential differentiation. Five months after transplantation, the donor cells had differentiated into neurons, oligodendrocytes and astrocytes. Transplantation restored DARPP-32 expression, synaptophysin density, myelin basic protein expression in the corpus callosum and astrocyte function. Conclusion: Altogether, these results strongly suggest that iPSC-NPCs transplantation induces neuroprotection and functional recovery in a mouse model of HD and should be taken forward for clinical trials in HD patients.

KW - astrocyte

KW - functional recovery

KW - glutamate toxicity

KW - human leukocyte antigen (HLA)

KW - Huntington’s disease (HD)

KW - induced pluripotent stem cell-derived neural precursor cells (iPSC-NPCs)

KW - inflammation

U2 - 10.1111/cpr.13082

DO - 10.1111/cpr.13082

M3 - Journal article

C2 - 34152047

AN - SCOPUS:85108367948

VL - 54

JO - Cell Proliferation

JF - Cell Proliferation

SN - 0960-7722

IS - 8

M1 - e13082

ER -

ID: 273364454