Glymphatic failure as a final common pathway to dementia

Research output: Contribution to journal › Review › Research › peer-review

Standard

Glymphatic failure as a final common pathway to dementia. / Nedergaard, Maiken; Goldman, Steven A.

In: Science (New York, N.Y.), Vol. 370, No. 6512, 2020, p. 50-56.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Nedergaard, M & Goldman, SA 2020, 'Glymphatic failure as a final common pathway to dementia', Science (New York, N.Y.), vol. 370, no. 6512, pp. 50-56. https://doi.org/10.1126/science.abb8739

APA

Nedergaard, M., & Goldman, S. A. (2020). Glymphatic failure as a final common pathway to dementia. Science (New York, N.Y.), 370(6512), 50-56. https://doi.org/10.1126/science.abb8739

Vancouver

Nedergaard M, Goldman SA. Glymphatic failure as a final common pathway to dementia. Science (New York, N.Y.). 2020;370(6512):50-56. https://doi.org/10.1126/science.abb8739

Author

Nedergaard, Maiken ; Goldman, Steven A. / Glymphatic failure as a final common pathway to dementia. In: Science (New York, N.Y.). 2020 ; Vol. 370, No. 6512. pp. 50-56.

Bibtex

@article{ca6282568a6047efba0557f40db50201,
title = "Glymphatic failure as a final common pathway to dementia",
abstract = "Sleep is evolutionarily conserved across all species, and impaired sleep is a common trait of the diseased brain. Sleep quality decreases as we age, and disruption of the regular sleep architecture is a frequent antecedent to the onset of dementia in neurodegenerative diseases. The glymphatic system, which clears the brain of protein waste products, is mostly active during sleep. Yet the glymphatic system degrades with age, suggesting a causal relationship between sleep disturbance and symptomatic progression in the neurodegenerative dementias. The ties that bind sleep, aging, glymphatic clearance, and protein aggregation have shed new light on the pathogenesis of a broad range of neurodegenerative diseases, for which glymphatic failure may constitute a therapeutically targetable final common pathway.",
author = "Maiken Nedergaard and Goldman, {Steven A}",
note = "Copyright {\textcopyright} 2020, American Association for the Advancement of Science.",
year = "2020",
doi = "10.1126/science.abb8739",
language = "English",
volume = "370",
pages = "50--56",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6512",

}

RIS

TY - JOUR

T1 - Glymphatic failure as a final common pathway to dementia

AU - Nedergaard, Maiken

AU - Goldman, Steven A

N1 - Copyright © 2020, American Association for the Advancement of Science.

PY - 2020

Y1 - 2020

N2 - Sleep is evolutionarily conserved across all species, and impaired sleep is a common trait of the diseased brain. Sleep quality decreases as we age, and disruption of the regular sleep architecture is a frequent antecedent to the onset of dementia in neurodegenerative diseases. The glymphatic system, which clears the brain of protein waste products, is mostly active during sleep. Yet the glymphatic system degrades with age, suggesting a causal relationship between sleep disturbance and symptomatic progression in the neurodegenerative dementias. The ties that bind sleep, aging, glymphatic clearance, and protein aggregation have shed new light on the pathogenesis of a broad range of neurodegenerative diseases, for which glymphatic failure may constitute a therapeutically targetable final common pathway.

AB - Sleep is evolutionarily conserved across all species, and impaired sleep is a common trait of the diseased brain. Sleep quality decreases as we age, and disruption of the regular sleep architecture is a frequent antecedent to the onset of dementia in neurodegenerative diseases. The glymphatic system, which clears the brain of protein waste products, is mostly active during sleep. Yet the glymphatic system degrades with age, suggesting a causal relationship between sleep disturbance and symptomatic progression in the neurodegenerative dementias. The ties that bind sleep, aging, glymphatic clearance, and protein aggregation have shed new light on the pathogenesis of a broad range of neurodegenerative diseases, for which glymphatic failure may constitute a therapeutically targetable final common pathway.

U2 - 10.1126/science.abb8739

DO - 10.1126/science.abb8739

M3 - Review

C2 - 33004510

VL - 370

SP - 50

EP - 56

JO - Science

JF - Science

SN - 0036-8075

IS - 6512

ER -

ID: 250123927