General Pathophysiology of Astroglia

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Standard

General Pathophysiology of Astroglia. / Verkhratsky, Alexei; Ho, Margaret S.; Vardjan, Nina; Zorec, Robert; Parpura, Vladimir.

Neuroglia in Neurodegenerative Diseases. ed. / Alexei Verkhratsky; Margaret S. Ho; Robert Zorec; Vladimir Parpura. Springer, 2019. p. 149-179 (Advances in Experimental Medicine and Biology, Vol. 1175).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Harvard

Verkhratsky, A, Ho, MS, Vardjan, N, Zorec, R & Parpura, V 2019, General Pathophysiology of Astroglia. in A Verkhratsky, MS Ho, R Zorec & V Parpura (eds), Neuroglia in Neurodegenerative Diseases. Springer, Advances in Experimental Medicine and Biology, vol. 1175, pp. 149-179. https://doi.org/10.1007/978-981-13-9913-8_7

APA

Verkhratsky, A., Ho, M. S., Vardjan, N., Zorec, R., & Parpura, V. (2019). General Pathophysiology of Astroglia. In A. Verkhratsky, M. S. Ho, R. Zorec, & V. Parpura (Eds.), Neuroglia in Neurodegenerative Diseases (pp. 149-179). Springer. Advances in Experimental Medicine and Biology Vol. 1175 https://doi.org/10.1007/978-981-13-9913-8_7

Vancouver

Verkhratsky A, Ho MS, Vardjan N, Zorec R, Parpura V. General Pathophysiology of Astroglia. In Verkhratsky A, Ho MS, Zorec R, Parpura V, editors, Neuroglia in Neurodegenerative Diseases. Springer. 2019. p. 149-179. (Advances in Experimental Medicine and Biology, Vol. 1175). https://doi.org/10.1007/978-981-13-9913-8_7

Author

Verkhratsky, Alexei ; Ho, Margaret S. ; Vardjan, Nina ; Zorec, Robert ; Parpura, Vladimir. / General Pathophysiology of Astroglia. Neuroglia in Neurodegenerative Diseases. editor / Alexei Verkhratsky ; Margaret S. Ho ; Robert Zorec ; Vladimir Parpura. Springer, 2019. pp. 149-179 (Advances in Experimental Medicine and Biology, Vol. 1175).

Bibtex

@inbook{4bf48d984e0442d9a2a599f630f0093d,
title = "General Pathophysiology of Astroglia",
abstract = "Astroglial cells are involved in most if not in all pathologies of the brain. These cells can change the morpho-functional properties in response to pathology or innate changes of these cells can lead to pathologies. Overall pathological changes in astroglia are complex and diverse and often vary with different disease stages. We classify astrogliopathologies into reactive astrogliosis, astrodegeneration with astroglial atrophy and loss of function, and pathological remodelling of astrocytes. Such changes can occur in neurological, neurodevelopmental, metabolic and psychiatric disorders as well as in infection and toxic insults. Mutation in astrocyte-specific genes leads to specific pathologies, such as Alexander disease, which is a leukodystrophy. We discuss changes in astroglia in the pathological context and identify some molecular entities underlying pathology. These entities within astroglia may repent targets for novel therapeutic intervention in the management of brain pathologies.",
keywords = "Alexander disease, Astrocyte, Autistic spectrum disorders, Epilepsy, Hepatic encephalopathy, Infectious diseases, Metabolic diseases, Neuropathology, Neurotrauma, Psychiatric diseases, Sepsis-associated encephalopathy, Stroke, Systemic inflammation, Toxic encephalopathy",
author = "Alexei Verkhratsky and Ho, {Margaret S.} and Nina Vardjan and Robert Zorec and Vladimir Parpura",
year = "2019",
doi = "10.1007/978-981-13-9913-8_7",
language = "English",
isbn = "978-981-13-9912-1",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer",
pages = "149--179",
editor = "Alexei Verkhratsky and Ho, {Margaret S.} and Robert Zorec and Vladimir Parpura",
booktitle = "Neuroglia in Neurodegenerative Diseases",
address = "Switzerland",

}

RIS

TY - CHAP

T1 - General Pathophysiology of Astroglia

AU - Verkhratsky, Alexei

AU - Ho, Margaret S.

AU - Vardjan, Nina

AU - Zorec, Robert

AU - Parpura, Vladimir

PY - 2019

Y1 - 2019

N2 - Astroglial cells are involved in most if not in all pathologies of the brain. These cells can change the morpho-functional properties in response to pathology or innate changes of these cells can lead to pathologies. Overall pathological changes in astroglia are complex and diverse and often vary with different disease stages. We classify astrogliopathologies into reactive astrogliosis, astrodegeneration with astroglial atrophy and loss of function, and pathological remodelling of astrocytes. Such changes can occur in neurological, neurodevelopmental, metabolic and psychiatric disorders as well as in infection and toxic insults. Mutation in astrocyte-specific genes leads to specific pathologies, such as Alexander disease, which is a leukodystrophy. We discuss changes in astroglia in the pathological context and identify some molecular entities underlying pathology. These entities within astroglia may repent targets for novel therapeutic intervention in the management of brain pathologies.

AB - Astroglial cells are involved in most if not in all pathologies of the brain. These cells can change the morpho-functional properties in response to pathology or innate changes of these cells can lead to pathologies. Overall pathological changes in astroglia are complex and diverse and often vary with different disease stages. We classify astrogliopathologies into reactive astrogliosis, astrodegeneration with astroglial atrophy and loss of function, and pathological remodelling of astrocytes. Such changes can occur in neurological, neurodevelopmental, metabolic and psychiatric disorders as well as in infection and toxic insults. Mutation in astrocyte-specific genes leads to specific pathologies, such as Alexander disease, which is a leukodystrophy. We discuss changes in astroglia in the pathological context and identify some molecular entities underlying pathology. These entities within astroglia may repent targets for novel therapeutic intervention in the management of brain pathologies.

KW - Alexander disease

KW - Astrocyte

KW - Autistic spectrum disorders

KW - Epilepsy

KW - Hepatic encephalopathy

KW - Infectious diseases

KW - Metabolic diseases

KW - Neuropathology

KW - Neurotrauma

KW - Psychiatric diseases

KW - Sepsis-associated encephalopathy

KW - Stroke

KW - Systemic inflammation

KW - Toxic encephalopathy

U2 - 10.1007/978-981-13-9913-8_7

DO - 10.1007/978-981-13-9913-8_7

M3 - Book chapter

C2 - 31583588

AN - SCOPUS:85072924601

SN - 978-981-13-9912-1

T3 - Advances in Experimental Medicine and Biology

SP - 149

EP - 179

BT - Neuroglia in Neurodegenerative Diseases

A2 - Verkhratsky, Alexei

A2 - Ho, Margaret S.

A2 - Zorec, Robert

A2 - Parpura, Vladimir

PB - Springer

ER -

ID: 231242214