Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation

Research output: Contribution to journal › Journal article › Research › peer-review

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Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation. / Wei, Helen Shinru; Kang, Hongyi; Rasheed, Izad-Yar Daniel; Zhou, Sitong; Lou, Nanhong; Gershteyn, Anna; McConnell, Evan Daniel; Wang, Yixuan; Richardson, Kristopher Emil; Palmer, Andre Francis; Xu, Chris; Wan, Jiandi; Nedergaard, Maiken.

In: Neuron, Vol. 91, No. 4, 17.08.2016, p. 851-862.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Wei, HS, Kang, H, Rasheed, I-YD, Zhou, S, Lou, N, Gershteyn, A, McConnell, ED, Wang, Y, Richardson, KE, Palmer, AF, Xu, C, Wan, J & Nedergaard, M 2016, 'Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation', Neuron, vol. 91, no. 4, pp. 851-862. https://doi.org/10.1016/j.neuron.2016.07.016

APA

Wei, H. S., Kang, H., Rasheed, I-Y. D., Zhou, S., Lou, N., Gershteyn, A., McConnell, E. D., Wang, Y., Richardson, K. E., Palmer, A. F., Xu, C., Wan, J., & Nedergaard, M. (2016). Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation. Neuron, 91(4), 851-862. https://doi.org/10.1016/j.neuron.2016.07.016

Vancouver

Wei HS, Kang H, Rasheed I-YD, Zhou S, Lou N, Gershteyn A et al. Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation. Neuron. 2016 Aug 17;91(4):851-862. https://doi.org/10.1016/j.neuron.2016.07.016

Author

Wei, Helen Shinru ; Kang, Hongyi ; Rasheed, Izad-Yar Daniel ; Zhou, Sitong ; Lou, Nanhong ; Gershteyn, Anna ; McConnell, Evan Daniel ; Wang, Yixuan ; Richardson, Kristopher Emil ; Palmer, Andre Francis ; Xu, Chris ; Wan, Jiandi ; Nedergaard, Maiken. / Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation. In: Neuron. 2016 ; Vol. 91, No. 4. pp. 851-862.

Bibtex

@article{8d5e83e6a6db4e4088a1c76930dece40,

title = "Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation",

abstract = "Energy production in the brain depends almost exclusively on oxidative metabolism. Neurons have small energy reserves and require a continuous supply of oxygen (O2). It is therefore not surprising that one of the hallmarks of normal brain function is the tight coupling between cerebral blood flow and neuronal activity. Since capillaries are embedded in the O2-consuming neuropil, we have here examined whether activity-dependent dips in O2 tension drive capillary hyperemia. In vivo analyses showed that transient dips in tissue O2 tension elicit capillary hyperemia. Ex vivo experiments revealed that red blood cells (RBCs) themselves act as O2 sensors that autonomously regulate their own deformability and thereby flow velocity through capillaries in response to physiological decreases in O2 tension. This observation has broad implications for understanding how local changes in blood flow are coupled to synaptic transmission.",

keywords = "Journal Article",

author = "Wei, {Helen Shinru} and Hongyi Kang and Rasheed, {Izad-Yar Daniel} and Sitong Zhou and Nanhong Lou and Anna Gershteyn and McConnell, {Evan Daniel} and Yixuan Wang and Richardson, {Kristopher Emil} and Palmer, {Andre Francis} and Chris Xu and Jiandi Wan and Maiken Nedergaard",

year = "2016",

month = aug,

day = "17",

doi = "10.1016/j.neuron.2016.07.016",

language = "English",

volume = "91",

pages = "851--862",

journal = "Neuron",

issn = "0896-6273",

publisher = "Cell Press",

number = "4",

}

RIS

TY - JOUR

T1 - Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation

AU - Wei, Helen Shinru

AU - Kang, Hongyi

AU - Rasheed, Izad-Yar Daniel

AU - Zhou, Sitong

AU - Lou, Nanhong

AU - Gershteyn, Anna

AU - McConnell, Evan Daniel

AU - Wang, Yixuan

AU - Richardson, Kristopher Emil

AU - Palmer, Andre Francis

AU - Xu, Chris

AU - Wan, Jiandi

AU - Nedergaard, Maiken

PY - 2016/8/17

Y1 - 2016/8/17

N2 - Energy production in the brain depends almost exclusively on oxidative metabolism. Neurons have small energy reserves and require a continuous supply of oxygen (O2). It is therefore not surprising that one of the hallmarks of normal brain function is the tight coupling between cerebral blood flow and neuronal activity. Since capillaries are embedded in the O2-consuming neuropil, we have here examined whether activity-dependent dips in O2 tension drive capillary hyperemia. In vivo analyses showed that transient dips in tissue O2 tension elicit capillary hyperemia. Ex vivo experiments revealed that red blood cells (RBCs) themselves act as O2 sensors that autonomously regulate their own deformability and thereby flow velocity through capillaries in response to physiological decreases in O2 tension. This observation has broad implications for understanding how local changes in blood flow are coupled to synaptic transmission.

AB - Energy production in the brain depends almost exclusively on oxidative metabolism. Neurons have small energy reserves and require a continuous supply of oxygen (O2). It is therefore not surprising that one of the hallmarks of normal brain function is the tight coupling between cerebral blood flow and neuronal activity. Since capillaries are embedded in the O2-consuming neuropil, we have here examined whether activity-dependent dips in O2 tension drive capillary hyperemia. In vivo analyses showed that transient dips in tissue O2 tension elicit capillary hyperemia. Ex vivo experiments revealed that red blood cells (RBCs) themselves act as O2 sensors that autonomously regulate their own deformability and thereby flow velocity through capillaries in response to physiological decreases in O2 tension. This observation has broad implications for understanding how local changes in blood flow are coupled to synaptic transmission.

KW - Journal Article

U2 - 10.1016/j.neuron.2016.07.016

DO - 10.1016/j.neuron.2016.07.016

M3 - Journal article

C2 - 27499087

VL - 91

SP - 851

EP - 862

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 4

ER -

ID: 164971619

Center for Translational Neuromedicine