Early impairments of visually-driven neuronal ensemble dynamics in the rTg4510 tauopathy mouse model
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Early impairments of visually-driven neuronal ensemble dynamics in the rTg4510 tauopathy mouse model. / Parka, Aleksandra; Degel, Caroline; Dreyer, Jakob; Richter, Ulrike; Hall, Benjamin; Bastlund, Jesper F.; Laursen, Bettina; Nedergaard, Maiken; Sotty, Florence; Botta, Paolo.
In: Neurobiology of Disease, Vol. 178, 106012, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Early impairments of visually-driven neuronal ensemble dynamics in the rTg4510 tauopathy mouse model
AU - Parka, Aleksandra
AU - Degel, Caroline
AU - Dreyer, Jakob
AU - Richter, Ulrike
AU - Hall, Benjamin
AU - Bastlund, Jesper F.
AU - Laursen, Bettina
AU - Nedergaard, Maiken
AU - Sotty, Florence
AU - Botta, Paolo
N1 - Publisher Copyright: © 2023
PY - 2023
Y1 - 2023
N2 - Tau protein pathology is a hallmark of many neurodegenerative diseases, including Alzheimer's Disease or frontotemporal dementia. Synaptic dysfunction and abnormal visual evoked potentials have been reported in murine models of tauopathy, but little is known about the state of the network activity on a single neuronal level prior to brain atrophy. In the present study, oscillatory rhythms and single-cell calcium activity of primary visual cortex pyramidal neuron population were investigated in basal and light evoked states in the rTg4510 tauopathy mouse model prior to neurodegeneration. We found a decrease in their responsivity and overall activity which was insensitive to GABAergic modulation. Despite an enhancement of basal state coactivation of cortical pyramidal neurons, a loss of input-output synchronicity was observed. Dysfunction of cortical pyramidal function was also reflected in a reduction of basal theta oscillations and enhanced susceptibility to a sub-convulsive dose of pentylenetetrazol in rTg4510 mice. Our results unveil impairments in visual cortical pyramidal neuron processing and define aberrant oscillations as biomarker candidates in early stages of neurodegenerative tauopathies.
AB - Tau protein pathology is a hallmark of many neurodegenerative diseases, including Alzheimer's Disease or frontotemporal dementia. Synaptic dysfunction and abnormal visual evoked potentials have been reported in murine models of tauopathy, but little is known about the state of the network activity on a single neuronal level prior to brain atrophy. In the present study, oscillatory rhythms and single-cell calcium activity of primary visual cortex pyramidal neuron population were investigated in basal and light evoked states in the rTg4510 tauopathy mouse model prior to neurodegeneration. We found a decrease in their responsivity and overall activity which was insensitive to GABAergic modulation. Despite an enhancement of basal state coactivation of cortical pyramidal neurons, a loss of input-output synchronicity was observed. Dysfunction of cortical pyramidal function was also reflected in a reduction of basal theta oscillations and enhanced susceptibility to a sub-convulsive dose of pentylenetetrazol in rTg4510 mice. Our results unveil impairments in visual cortical pyramidal neuron processing and define aberrant oscillations as biomarker candidates in early stages of neurodegenerative tauopathies.
KW - Alzheimer's disease
KW - Calcium imaging
KW - Diazepam
KW - Electroencephalography
KW - Frontotemporal dementia
KW - Pentylenetetrazol
KW - Pyramidal neurons
KW - rTg4510
KW - Tauopathy
KW - Visual cortex
U2 - 10.1016/j.nbd.2023.106012
DO - 10.1016/j.nbd.2023.106012
M3 - Journal article
C2 - 36696792
AN - SCOPUS:85146702243
VL - 178
JO - Neurobiology of Disease
JF - Neurobiology of Disease
SN - 0969-9961
M1 - 106012
ER -
ID: 371022052