Defining novel functions for cerebrospinal fluid in ALS pathophysiology

Research output: Contribution to journal › Review › Research › peer-review

Standard

Defining novel functions for cerebrospinal fluid in ALS pathophysiology. / Ng Kee Kwong, Koy Chong; Mehta, Arpan R.; Nedergaard, Maiken; Chandran, Siddharthan.

In: Acta Neuropathologica Communications, Vol. 8, No. 1, 2020.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Ng Kee Kwong, KC, Mehta, AR, Nedergaard, M & Chandran, S 2020, 'Defining novel functions for cerebrospinal fluid in ALS pathophysiology', Acta Neuropathologica Communications, vol. 8, no. 1. https://doi.org/10.1186/s40478-020-01018-0

APA

Ng Kee Kwong, K. C., Mehta, A. R., Nedergaard, M., & Chandran, S. (2020). Defining novel functions for cerebrospinal fluid in ALS pathophysiology. Acta Neuropathologica Communications, 8(1). https://doi.org/10.1186/s40478-020-01018-0

Vancouver

Ng Kee Kwong KC, Mehta AR, Nedergaard M, Chandran S. Defining novel functions for cerebrospinal fluid in ALS pathophysiology. Acta Neuropathologica Communications. 2020;8(1). https://doi.org/10.1186/s40478-020-01018-0

Author

Ng Kee Kwong, Koy Chong ; Mehta, Arpan R. ; Nedergaard, Maiken ; Chandran, Siddharthan. / Defining novel functions for cerebrospinal fluid in ALS pathophysiology. In: Acta Neuropathologica Communications. 2020 ; Vol. 8, No. 1.

Bibtex

@article{62d9aa872efa48b49bd05f231695577d,
title = "Defining novel functions for cerebrospinal fluid in ALS pathophysiology",
abstract = "Despite the considerable progress made towards understanding ALS pathophysiology, several key features of ALS remain unexplained, from its aetiology to its epidemiological aspects. The glymphatic system, which has recently been recognised as a major clearance pathway for the brain, has received considerable attention in several neurological conditions, particularly Alzheimer's disease. Its significance in ALS has, however, been little addressed. This perspective article therefore aims to assess the possibility of CSF contribution in ALS by considering various lines of evidence, including the abnormal composition of ALS-CSF, its toxicity and the evidence for impaired CSF dynamics in ALS patients. We also describe a potential role for CSF circulation in determining disease spread as well as the importance of CSF dynamics in ALS neurotherapeutics. We propose that a CSF model could potentially offer additional avenues to explore currently unexplained features of ALS, ultimately leading to new treatment options for people with ALS.",
keywords = "Ageing, Amyotrophic lateral sclerosis, Cerebrospinal fluid, Frontotemporal dementia, Glymphatic system, Motor neuron disease",
author = "{Ng Kee Kwong}, {Koy Chong} and Mehta, {Arpan R.} and Maiken Nedergaard and Siddharthan Chandran",
year = "2020",
doi = "10.1186/s40478-020-01018-0",
language = "English",
volume = "8",
journal = "Acta neuropathologica communications",
issn = "2051-5960",
publisher = "BMJ, Springer Nature",
number = "1",

}

RIS

TY - JOUR

T1 - Defining novel functions for cerebrospinal fluid in ALS pathophysiology

AU - Ng Kee Kwong, Koy Chong

AU - Mehta, Arpan R.

AU - Nedergaard, Maiken

AU - Chandran, Siddharthan

PY - 2020

Y1 - 2020

N2 - Despite the considerable progress made towards understanding ALS pathophysiology, several key features of ALS remain unexplained, from its aetiology to its epidemiological aspects. The glymphatic system, which has recently been recognised as a major clearance pathway for the brain, has received considerable attention in several neurological conditions, particularly Alzheimer's disease. Its significance in ALS has, however, been little addressed. This perspective article therefore aims to assess the possibility of CSF contribution in ALS by considering various lines of evidence, including the abnormal composition of ALS-CSF, its toxicity and the evidence for impaired CSF dynamics in ALS patients. We also describe a potential role for CSF circulation in determining disease spread as well as the importance of CSF dynamics in ALS neurotherapeutics. We propose that a CSF model could potentially offer additional avenues to explore currently unexplained features of ALS, ultimately leading to new treatment options for people with ALS.

AB - Despite the considerable progress made towards understanding ALS pathophysiology, several key features of ALS remain unexplained, from its aetiology to its epidemiological aspects. The glymphatic system, which has recently been recognised as a major clearance pathway for the brain, has received considerable attention in several neurological conditions, particularly Alzheimer's disease. Its significance in ALS has, however, been little addressed. This perspective article therefore aims to assess the possibility of CSF contribution in ALS by considering various lines of evidence, including the abnormal composition of ALS-CSF, its toxicity and the evidence for impaired CSF dynamics in ALS patients. We also describe a potential role for CSF circulation in determining disease spread as well as the importance of CSF dynamics in ALS neurotherapeutics. We propose that a CSF model could potentially offer additional avenues to explore currently unexplained features of ALS, ultimately leading to new treatment options for people with ALS.

KW - Ageing

KW - Amyotrophic lateral sclerosis

KW - Cerebrospinal fluid

KW - Frontotemporal dementia

KW - Glymphatic system

KW - Motor neuron disease

U2 - 10.1186/s40478-020-01018-0

DO - 10.1186/s40478-020-01018-0

M3 - Review

C2 - 32819425

AN - SCOPUS:85089769274

VL - 8

JO - Acta neuropathologica communications

JF - Acta neuropathologica communications

SN - 2051-5960

IS - 1

ER -

ID: 248758576