Circadian control of brain glymphatic and lymphatic fluid flow

Research output: Contribution to journal › Journal article › Research › peer-review

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Circadian control of brain glymphatic and lymphatic fluid flow. / Hablitz, Lauren M.; Plá, Virginia; Giannetto, Michael; Vinitsky, Hanna S.; Stæger, Frederik Filip; Metcalfe, Tanner; Nguyen, Rebecca; Benrais, Abdellatif; Nedergaard, Maiken.

In: Nature Communications, Vol. 11, No. 1, 4411, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hablitz, LM, Plá, V, Giannetto, M, Vinitsky, HS, Stæger, FF, Metcalfe, T, Nguyen, R, Benrais, A & Nedergaard, M 2020, 'Circadian control of brain glymphatic and lymphatic fluid flow', Nature Communications, vol. 11, no. 1, 4411. https://doi.org/10.1038/s41467-020-18115-2

APA

Hablitz, L. M., Plá, V., Giannetto, M., Vinitsky, H. S., Stæger, F. F., Metcalfe, T., Nguyen, R., Benrais, A., & Nedergaard, M. (2020). Circadian control of brain glymphatic and lymphatic fluid flow. Nature Communications, 11(1), [4411]. https://doi.org/10.1038/s41467-020-18115-2

Vancouver

Hablitz LM, Plá V, Giannetto M, Vinitsky HS, Stæger FF, Metcalfe T et al. Circadian control of brain glymphatic and lymphatic fluid flow. Nature Communications. 2020;11(1). 4411. https://doi.org/10.1038/s41467-020-18115-2

Author

Hablitz, Lauren M. ; Plá, Virginia ; Giannetto, Michael ; Vinitsky, Hanna S. ; Stæger, Frederik Filip ; Metcalfe, Tanner ; Nguyen, Rebecca ; Benrais, Abdellatif ; Nedergaard, Maiken. / Circadian control of brain glymphatic and lymphatic fluid flow. In: Nature Communications. 2020 ; Vol. 11, No. 1.

Bibtex

@article{af618c91ed274215af051d86e22aa9dc,
title = "Circadian control of brain glymphatic and lymphatic fluid flow",
abstract = "The glymphatic system is a network of perivascular spaces that promotes movement of cerebrospinal fluid (CSF) into the brain and clearance of metabolic waste. This fluid transport system is supported by the water channel aquaporin-4 (AQP4) localized to vascular endfeet of astrocytes. The glymphatic system is more effective during sleep, but whether sleep timing promotes glymphatic function remains unknown. We here show glymphatic influx and clearance exhibit endogenous, circadian rhythms peaking during the mid-rest phase of mice. Drainage of CSF from the cisterna magna to the lymph nodes exhibits daily variation opposite to glymphatic influx, suggesting distribution of CSF throughout the animal depends on time-of-day. The perivascular polarization of AQP4 is highest during the rest phase and loss of AQP4 eliminates the day-night difference in both glymphatic influx and drainage to the lymph nodes. We conclude that CSF distribution is under circadian control and that AQP4 supports this rhythm.",
author = "Hablitz, {Lauren M.} and Virginia Pl{\'a} and Michael Giannetto and Vinitsky, {Hanna S.} and St{\ae}ger, {Frederik Filip} and Tanner Metcalfe and Rebecca Nguyen and Abdellatif Benrais and Maiken Nedergaard",
year = "2020",
doi = "10.1038/s41467-020-18115-2",
language = "English",
volume = "11",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Circadian control of brain glymphatic and lymphatic fluid flow

AU - Hablitz, Lauren M.

AU - Plá, Virginia

AU - Giannetto, Michael

AU - Vinitsky, Hanna S.

AU - Stæger, Frederik Filip

AU - Metcalfe, Tanner

AU - Nguyen, Rebecca

AU - Benrais, Abdellatif

AU - Nedergaard, Maiken

PY - 2020

Y1 - 2020

N2 - The glymphatic system is a network of perivascular spaces that promotes movement of cerebrospinal fluid (CSF) into the brain and clearance of metabolic waste. This fluid transport system is supported by the water channel aquaporin-4 (AQP4) localized to vascular endfeet of astrocytes. The glymphatic system is more effective during sleep, but whether sleep timing promotes glymphatic function remains unknown. We here show glymphatic influx and clearance exhibit endogenous, circadian rhythms peaking during the mid-rest phase of mice. Drainage of CSF from the cisterna magna to the lymph nodes exhibits daily variation opposite to glymphatic influx, suggesting distribution of CSF throughout the animal depends on time-of-day. The perivascular polarization of AQP4 is highest during the rest phase and loss of AQP4 eliminates the day-night difference in both glymphatic influx and drainage to the lymph nodes. We conclude that CSF distribution is under circadian control and that AQP4 supports this rhythm.

AB - The glymphatic system is a network of perivascular spaces that promotes movement of cerebrospinal fluid (CSF) into the brain and clearance of metabolic waste. This fluid transport system is supported by the water channel aquaporin-4 (AQP4) localized to vascular endfeet of astrocytes. The glymphatic system is more effective during sleep, but whether sleep timing promotes glymphatic function remains unknown. We here show glymphatic influx and clearance exhibit endogenous, circadian rhythms peaking during the mid-rest phase of mice. Drainage of CSF from the cisterna magna to the lymph nodes exhibits daily variation opposite to glymphatic influx, suggesting distribution of CSF throughout the animal depends on time-of-day. The perivascular polarization of AQP4 is highest during the rest phase and loss of AQP4 eliminates the day-night difference in both glymphatic influx and drainage to the lymph nodes. We conclude that CSF distribution is under circadian control and that AQP4 supports this rhythm.

U2 - 10.1038/s41467-020-18115-2

DO - 10.1038/s41467-020-18115-2

M3 - Journal article

C2 - 32879313

AN - SCOPUS:85090082122

VL - 11

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 4411

ER -

ID: 256260664