Cerebrospinal fluid influx drives acute ischemic tissue swelling

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Cerebrospinal fluid influx drives acute ischemic tissue swelling. / Mestre, Humberto; Du, Ting; Sweeney, Amanda M.; Liu, Guojun; Samson, Andrew J.; Peng, Weiguo; Mortensen, Kristian Nygaard; Stæger, Frederik Filip; Bork, Peter A.R.; Bashford, Logan; Toro, Edna R.; Tithof, Jeffrey; Kelley, Douglas H.; Thomas, John H.; Hjorth, Poul G.; Martens, Erik A.; Mehta, Rupal I.; Solis, Orestes; Blinder, Pablo; Kleinfeld, David; Hirase, Hajime; Mori, Yuki; Nedergaard, Maiken.

In: Science, Vol. 367, No. 6483, eaaw7462, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Mestre, H, Du, T, Sweeney, AM, Liu, G, Samson, AJ, Peng, W, Mortensen, KN, Stæger, FF, Bork, PAR, Bashford, L, Toro, ER, Tithof, J, Kelley, DH, Thomas, JH, Hjorth, PG, Martens, EA, Mehta, RI, Solis, O, Blinder, P, Kleinfeld, D, Hirase, H, Mori, Y & Nedergaard, M 2020, 'Cerebrospinal fluid influx drives acute ischemic tissue swelling', Science, vol. 367, no. 6483, eaaw7462. https://doi.org/10.1126/science.aax7171

APA

Mestre, H., Du, T., Sweeney, A. M., Liu, G., Samson, A. J., Peng, W., Mortensen, K. N., Stæger, F. F., Bork, P. A. R., Bashford, L., Toro, E. R., Tithof, J., Kelley, D. H., Thomas, J. H., Hjorth, P. G., Martens, E. A., Mehta, R. I., Solis, O., Blinder, P., ... Nedergaard, M. (2020). Cerebrospinal fluid influx drives acute ischemic tissue swelling. Science, 367(6483), [eaaw7462]. https://doi.org/10.1126/science.aax7171

Vancouver

Mestre H, Du T, Sweeney AM, Liu G, Samson AJ, Peng W et al. Cerebrospinal fluid influx drives acute ischemic tissue swelling. Science. 2020;367(6483). eaaw7462. https://doi.org/10.1126/science.aax7171

Author

Mestre, Humberto ; Du, Ting ; Sweeney, Amanda M. ; Liu, Guojun ; Samson, Andrew J. ; Peng, Weiguo ; Mortensen, Kristian Nygaard ; Stæger, Frederik Filip ; Bork, Peter A.R. ; Bashford, Logan ; Toro, Edna R. ; Tithof, Jeffrey ; Kelley, Douglas H. ; Thomas, John H. ; Hjorth, Poul G. ; Martens, Erik A. ; Mehta, Rupal I. ; Solis, Orestes ; Blinder, Pablo ; Kleinfeld, David ; Hirase, Hajime ; Mori, Yuki ; Nedergaard, Maiken. / Cerebrospinal fluid influx drives acute ischemic tissue swelling. In: Science. 2020 ; Vol. 367, No. 6483.

Bibtex

@article{1fbab54aedb244ffb0633ea606dc8e24,
title = "Cerebrospinal fluid influx drives acute ischemic tissue swelling",
abstract = "Stroke affects millions each year. Poststroke brain edema predicts the severity of eventual stroke damage, yet our concept of how edema develops is incomplete and treatment options remain limited. In early stages, fluid accumulation occurs owing to a net gain of ions, widely thought to enter from the vascular compartment. Here, we used magnetic resonance imaging, radiolabeled tracers, and multiphoton imaging in rodents to show instead that cerebrospinal fluid surrounding the brain enters the tissue within minutes of an ischemic insult along perivascular flow channels. This process was initiated by ischemic spreading depolarizations along with subsequent vasoconstriction, which in turn enlarged the perivascular spaces and doubled glymphatic inflow speeds. Thus, our understanding of poststroke edema needs to be revised, and these findings could provide a conceptual basis for development of alternative treatment strategies.",
author = "Humberto Mestre and Ting Du and Sweeney, {Amanda M.} and Guojun Liu and Samson, {Andrew J.} and Weiguo Peng and Mortensen, {Kristian Nygaard} and St{\ae}ger, {Frederik Filip} and Bork, {Peter A.R.} and Logan Bashford and Toro, {Edna R.} and Jeffrey Tithof and Kelley, {Douglas H.} and Thomas, {John H.} and Hjorth, {Poul G.} and Martens, {Erik A.} and Mehta, {Rupal I.} and Orestes Solis and Pablo Blinder and David Kleinfeld and Hajime Hirase and Yuki Mori and Maiken Nedergaard",
year = "2020",
doi = "10.1126/science.aax7171",
language = "English",
volume = "367",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6483",

}

RIS

TY - JOUR

T1 - Cerebrospinal fluid influx drives acute ischemic tissue swelling

AU - Mestre, Humberto

AU - Du, Ting

AU - Sweeney, Amanda M.

AU - Liu, Guojun

AU - Samson, Andrew J.

AU - Peng, Weiguo

AU - Mortensen, Kristian Nygaard

AU - Stæger, Frederik Filip

AU - Bork, Peter A.R.

AU - Bashford, Logan

AU - Toro, Edna R.

AU - Tithof, Jeffrey

AU - Kelley, Douglas H.

AU - Thomas, John H.

AU - Hjorth, Poul G.

AU - Martens, Erik A.

AU - Mehta, Rupal I.

AU - Solis, Orestes

AU - Blinder, Pablo

AU - Kleinfeld, David

AU - Hirase, Hajime

AU - Mori, Yuki

AU - Nedergaard, Maiken

PY - 2020

Y1 - 2020

N2 - Stroke affects millions each year. Poststroke brain edema predicts the severity of eventual stroke damage, yet our concept of how edema develops is incomplete and treatment options remain limited. In early stages, fluid accumulation occurs owing to a net gain of ions, widely thought to enter from the vascular compartment. Here, we used magnetic resonance imaging, radiolabeled tracers, and multiphoton imaging in rodents to show instead that cerebrospinal fluid surrounding the brain enters the tissue within minutes of an ischemic insult along perivascular flow channels. This process was initiated by ischemic spreading depolarizations along with subsequent vasoconstriction, which in turn enlarged the perivascular spaces and doubled glymphatic inflow speeds. Thus, our understanding of poststroke edema needs to be revised, and these findings could provide a conceptual basis for development of alternative treatment strategies.

AB - Stroke affects millions each year. Poststroke brain edema predicts the severity of eventual stroke damage, yet our concept of how edema develops is incomplete and treatment options remain limited. In early stages, fluid accumulation occurs owing to a net gain of ions, widely thought to enter from the vascular compartment. Here, we used magnetic resonance imaging, radiolabeled tracers, and multiphoton imaging in rodents to show instead that cerebrospinal fluid surrounding the brain enters the tissue within minutes of an ischemic insult along perivascular flow channels. This process was initiated by ischemic spreading depolarizations along with subsequent vasoconstriction, which in turn enlarged the perivascular spaces and doubled glymphatic inflow speeds. Thus, our understanding of poststroke edema needs to be revised, and these findings could provide a conceptual basis for development of alternative treatment strategies.

U2 - 10.1126/science.aax7171

DO - 10.1126/science.aax7171

M3 - Journal article

C2 - 32001524

AN - SCOPUS:85081917924

VL - 367

JO - Science

JF - Science

SN - 0036-8075

IS - 6483

M1 - eaaw7462

ER -

ID: 238530939