Cerebral small vessel disease

Center for Translational Neuromedicine

Cerebral small vessel disease: A glymphopathy?

Research output: Contribution to journal › Review › Research › peer-review

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Cerebral small vessel disease : A glymphopathy? / Benveniste, Helene; Nedergaard, Maiken.

In: Current Opinion in Neurobiology, Vol. 72, 2021, p. 15-21.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Benveniste, H & Nedergaard, M 2021, 'Cerebral small vessel disease: A glymphopathy?', Current Opinion in Neurobiology, vol. 72, pp. 15-21. https://doi.org/10.1016/j.conb.2021.07.006

APA

Benveniste, H., & Nedergaard, M. (2021). Cerebral small vessel disease: A glymphopathy? Current Opinion in Neurobiology, 72, 15-21. https://doi.org/10.1016/j.conb.2021.07.006

Vancouver

Benveniste H, Nedergaard M. Cerebral small vessel disease: A glymphopathy? Current Opinion in Neurobiology. 2021;72:15-21. https://doi.org/10.1016/j.conb.2021.07.006

Author

Benveniste, Helene ; Nedergaard, Maiken. / Cerebral small vessel disease : A glymphopathy?. In: Current Opinion in Neurobiology. 2021 ; Vol. 72. pp. 15-21.

Bibtex

@article{3aed74ab006647c6a9fb91d6ed5b272b,

title = "Cerebral small vessel disease: A glymphopathy?",

abstract = "Small vessel disease (SVD) is a common instigator of dementia in the aging population. The hallmarks of SVD are enlargement of the perivascular spaces and white matter hyperintensities. The latter represents local fluid accumulation in white matter that either subsides or develops into lacunar infarcts. We here propose that failure of brain fluid transport-via the glymphatic system-plays a key role in initiation and progression of SVD. Our major case for this concept is that perivascular spaces are utilized as waterways for influx of cerebrospinal fluid. Stagnation of glymphatic transport may drive loss of brain fluid homeostasis leading to transient white matter edema, perivascular dilation, and ultimately demyelination. This review will discuss how glymphatic rodent studies of hypertension and diabetes have provided new insight into the pathogenesis of SVD.",

author = "Helene Benveniste and Maiken Nedergaard",

year = "2021",

doi = "10.1016/j.conb.2021.07.006",

language = "English",

volume = "72",

pages = "15--21",

journal = "Current Opinion in Neurobiology",

issn = "0959-4388",

publisher = "Elsevier Ltd. * Current Opinion Journals",

}

RIS

TY - JOUR

T1 - Cerebral small vessel disease

T2 - A glymphopathy?

AU - Benveniste, Helene

AU - Nedergaard, Maiken

PY - 2021

Y1 - 2021

N2 - Small vessel disease (SVD) is a common instigator of dementia in the aging population. The hallmarks of SVD are enlargement of the perivascular spaces and white matter hyperintensities. The latter represents local fluid accumulation in white matter that either subsides or develops into lacunar infarcts. We here propose that failure of brain fluid transport-via the glymphatic system-plays a key role in initiation and progression of SVD. Our major case for this concept is that perivascular spaces are utilized as waterways for influx of cerebrospinal fluid. Stagnation of glymphatic transport may drive loss of brain fluid homeostasis leading to transient white matter edema, perivascular dilation, and ultimately demyelination. This review will discuss how glymphatic rodent studies of hypertension and diabetes have provided new insight into the pathogenesis of SVD.

AB - Small vessel disease (SVD) is a common instigator of dementia in the aging population. The hallmarks of SVD are enlargement of the perivascular spaces and white matter hyperintensities. The latter represents local fluid accumulation in white matter that either subsides or develops into lacunar infarcts. We here propose that failure of brain fluid transport-via the glymphatic system-plays a key role in initiation and progression of SVD. Our major case for this concept is that perivascular spaces are utilized as waterways for influx of cerebrospinal fluid. Stagnation of glymphatic transport may drive loss of brain fluid homeostasis leading to transient white matter edema, perivascular dilation, and ultimately demyelination. This review will discuss how glymphatic rodent studies of hypertension and diabetes have provided new insight into the pathogenesis of SVD.

U2 - 10.1016/j.conb.2021.07.006

DO - 10.1016/j.conb.2021.07.006

M3 - Review

C2 - 34407477

VL - 72

SP - 15

EP - 21

JO - Current Opinion in Neurobiology

JF - Current Opinion in Neurobiology

SN - 0959-4388

ER -

ID: 288921434