Astroglia in Sepsis Associated Encephalopathy

Research output: Contribution to journal › Review › Research › peer-review

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Astroglia in Sepsis Associated Encephalopathy. / Shulyatnikova, Tatyana; Verkhratsky, Alexei.

In: Neurochemical Research, Vol. 45, 2020, p. 83-99.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Shulyatnikova, T & Verkhratsky, A 2020, 'Astroglia in Sepsis Associated Encephalopathy', Neurochemical Research, vol. 45, pp. 83-99. https://doi.org/10.1007/s11064-019-02743-2

APA

Shulyatnikova, T., & Verkhratsky, A. (2020). Astroglia in Sepsis Associated Encephalopathy. Neurochemical Research, 45, 83-99. https://doi.org/10.1007/s11064-019-02743-2

Vancouver

Shulyatnikova T, Verkhratsky A. Astroglia in Sepsis Associated Encephalopathy. Neurochemical Research. 2020;45:83-99. https://doi.org/10.1007/s11064-019-02743-2

Author

Shulyatnikova, Tatyana ; Verkhratsky, Alexei. / Astroglia in Sepsis Associated Encephalopathy. In: Neurochemical Research. 2020 ; Vol. 45. pp. 83-99.

Bibtex

@article{2df426e0cc854c83804e068057a13c70,
title = "Astroglia in Sepsis Associated Encephalopathy",
abstract = "Cellular pathophysiology of sepsis associated encephalopathy (SAE) remains poorly characterised. Brain pathology in SAE, which is manifested by impaired perception, consciousness and cognition, results from multifactorial events, including high levels of systemic cytokines, microbial components and endotoxins, which all damage the brain barriers, instigate neuroinflammation and cause homeostatic failure. Astrocytes, being the principal homeostatic cells of the central nervous system contribute to the brain defence against infection. Forming multifunctional anatomical barriers, astroglial cells maintain brain-systemic interfaces and restrict the damage to the nervous tissue. Astrocytes detect, produce and integrate inflammatory signals between immune cells and cells of brain parenchyma, thus regulating brain immune response. In SAE astrocytes are present in both reactive and astrogliopathic states; balance between these states define evolution of pathology and neurological outcomes. In humans pathophysiology of SAE is complicated by frequent presence of comorbidities, as well as age-related remodelling of the brain tissue with senescence of astroglia; these confounding factors further impact upon SAE progression and neurological deficits.",
keywords = "Asrtogliopathy, Astrocyte reactivity, Astroglia, Blood brain barrier, Infection, Sepsis associated encephalopathy, Sepsis signalling",
author = "Tatyana Shulyatnikova and Alexei Verkhratsky",
year = "2020",
doi = "10.1007/s11064-019-02743-2",
language = "English",
volume = "45",
pages = "83--99",
journal = "Neurochemical Research",
issn = "0364-3190",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Astroglia in Sepsis Associated Encephalopathy

AU - Shulyatnikova, Tatyana

AU - Verkhratsky, Alexei

PY - 2020

Y1 - 2020

N2 - Cellular pathophysiology of sepsis associated encephalopathy (SAE) remains poorly characterised. Brain pathology in SAE, which is manifested by impaired perception, consciousness and cognition, results from multifactorial events, including high levels of systemic cytokines, microbial components and endotoxins, which all damage the brain barriers, instigate neuroinflammation and cause homeostatic failure. Astrocytes, being the principal homeostatic cells of the central nervous system contribute to the brain defence against infection. Forming multifunctional anatomical barriers, astroglial cells maintain brain-systemic interfaces and restrict the damage to the nervous tissue. Astrocytes detect, produce and integrate inflammatory signals between immune cells and cells of brain parenchyma, thus regulating brain immune response. In SAE astrocytes are present in both reactive and astrogliopathic states; balance between these states define evolution of pathology and neurological outcomes. In humans pathophysiology of SAE is complicated by frequent presence of comorbidities, as well as age-related remodelling of the brain tissue with senescence of astroglia; these confounding factors further impact upon SAE progression and neurological deficits.

AB - Cellular pathophysiology of sepsis associated encephalopathy (SAE) remains poorly characterised. Brain pathology in SAE, which is manifested by impaired perception, consciousness and cognition, results from multifactorial events, including high levels of systemic cytokines, microbial components and endotoxins, which all damage the brain barriers, instigate neuroinflammation and cause homeostatic failure. Astrocytes, being the principal homeostatic cells of the central nervous system contribute to the brain defence against infection. Forming multifunctional anatomical barriers, astroglial cells maintain brain-systemic interfaces and restrict the damage to the nervous tissue. Astrocytes detect, produce and integrate inflammatory signals between immune cells and cells of brain parenchyma, thus regulating brain immune response. In SAE astrocytes are present in both reactive and astrogliopathic states; balance between these states define evolution of pathology and neurological outcomes. In humans pathophysiology of SAE is complicated by frequent presence of comorbidities, as well as age-related remodelling of the brain tissue with senescence of astroglia; these confounding factors further impact upon SAE progression and neurological deficits.

KW - Asrtogliopathy

KW - Astrocyte reactivity

KW - Astroglia

KW - Blood brain barrier

KW - Infection

KW - Sepsis associated encephalopathy

KW - Sepsis signalling

U2 - 10.1007/s11064-019-02743-2

DO - 10.1007/s11064-019-02743-2

M3 - Review

C2 - 30778837

AN - SCOPUS:85061731463

VL - 45

SP - 83

EP - 99

JO - Neurochemical Research

JF - Neurochemical Research

SN - 0364-3190

ER -

ID: 226256449