Astroglia in Alzheimer’s Disease

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Standard

Astroglia in Alzheimer’s Disease. / Verkhratsky, Alexei; Parpura, Vladimir; Rodriguez-Arellano, Jose Julio; Zorec, Robert.

Neuroglia in Neurodegenerative Diseases. ed. / Alexei Verkhratsky; Margaret S. Ho; Robert Zorec; Vladimir Parpura. Springer, 2019. p. 273-324 (Advances in Experimental Medicine and Biology, Vol. 1175).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Harvard

Verkhratsky, A, Parpura, V, Rodriguez-Arellano, JJ & Zorec, R 2019, Astroglia in Alzheimer’s Disease. in A Verkhratsky, MS Ho, R Zorec & V Parpura (eds), Neuroglia in Neurodegenerative Diseases. Springer, Advances in Experimental Medicine and Biology, vol. 1175, pp. 273-324. https://doi.org/10.1007/978-981-13-9913-8_11

APA

Verkhratsky, A., Parpura, V., Rodriguez-Arellano, J. J., & Zorec, R. (2019). Astroglia in Alzheimer’s Disease. In A. Verkhratsky, M. S. Ho, R. Zorec, & V. Parpura (Eds.), Neuroglia in Neurodegenerative Diseases (pp. 273-324). Springer. Advances in Experimental Medicine and Biology Vol. 1175 https://doi.org/10.1007/978-981-13-9913-8_11

Vancouver

Verkhratsky A, Parpura V, Rodriguez-Arellano JJ, Zorec R. Astroglia in Alzheimer’s Disease. In Verkhratsky A, Ho MS, Zorec R, Parpura V, editors, Neuroglia in Neurodegenerative Diseases. Springer. 2019. p. 273-324. (Advances in Experimental Medicine and Biology, Vol. 1175). https://doi.org/10.1007/978-981-13-9913-8_11

Author

Verkhratsky, Alexei ; Parpura, Vladimir ; Rodriguez-Arellano, Jose Julio ; Zorec, Robert. / Astroglia in Alzheimer’s Disease. Neuroglia in Neurodegenerative Diseases. editor / Alexei Verkhratsky ; Margaret S. Ho ; Robert Zorec ; Vladimir Parpura. Springer, 2019. pp. 273-324 (Advances in Experimental Medicine and Biology, Vol. 1175).

Bibtex

@inbook{652d8fb57c294db68cd0084ca9ac9fd8,
title = "Astroglia in Alzheimer{\textquoteright}s Disease",
abstract = "Alzheimer{\textquoteright}s disease is the most common cause of dementia. Cellular changes in the brains of the patients suffering from Alzheimer{\textquoteright}s disease occur well in advance of the clinical symptoms. At the cellular level, the most dramatic is a demise of neurones. As astroglial cells carry out homeostatic functions of the brain, it is certain that these cells are at least in part a cause of Alzheimer{\textquoteright}s disease. Historically, Alois Alzheimer himself has recognised this at the dawn of the disease description. However, the role of astroglia in this disease has been understudied. In this chapter, we summarise the various aspects of glial contribution to this disease and outline the potential of using these cells in prevention (exercise and environmental enrichment) and intervention of this devastating disease.",
keywords = "Alzheimer{\textquoteright}s disease, Astrocytes, Astroglial atrophy, Calcium signalling, Neurodegeneration, Pathological ageing, Stem cells",
author = "Alexei Verkhratsky and Vladimir Parpura and Rodriguez-Arellano, {Jose Julio} and Robert Zorec",
year = "2019",
doi = "10.1007/978-981-13-9913-8_11",
language = "English",
isbn = "978-981-13-9912-1",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer",
pages = "273--324",
editor = "Alexei Verkhratsky and Ho, {Margaret S.} and Robert Zorec and Vladimir Parpura",
booktitle = "Neuroglia in Neurodegenerative Diseases",
address = "Switzerland",

}

RIS

TY - CHAP

T1 - Astroglia in Alzheimer’s Disease

AU - Verkhratsky, Alexei

AU - Parpura, Vladimir

AU - Rodriguez-Arellano, Jose Julio

AU - Zorec, Robert

PY - 2019

Y1 - 2019

N2 - Alzheimer’s disease is the most common cause of dementia. Cellular changes in the brains of the patients suffering from Alzheimer’s disease occur well in advance of the clinical symptoms. At the cellular level, the most dramatic is a demise of neurones. As astroglial cells carry out homeostatic functions of the brain, it is certain that these cells are at least in part a cause of Alzheimer’s disease. Historically, Alois Alzheimer himself has recognised this at the dawn of the disease description. However, the role of astroglia in this disease has been understudied. In this chapter, we summarise the various aspects of glial contribution to this disease and outline the potential of using these cells in prevention (exercise and environmental enrichment) and intervention of this devastating disease.

AB - Alzheimer’s disease is the most common cause of dementia. Cellular changes in the brains of the patients suffering from Alzheimer’s disease occur well in advance of the clinical symptoms. At the cellular level, the most dramatic is a demise of neurones. As astroglial cells carry out homeostatic functions of the brain, it is certain that these cells are at least in part a cause of Alzheimer’s disease. Historically, Alois Alzheimer himself has recognised this at the dawn of the disease description. However, the role of astroglia in this disease has been understudied. In this chapter, we summarise the various aspects of glial contribution to this disease and outline the potential of using these cells in prevention (exercise and environmental enrichment) and intervention of this devastating disease.

KW - Alzheimer’s disease

KW - Astrocytes

KW - Astroglial atrophy

KW - Calcium signalling

KW - Neurodegeneration

KW - Pathological ageing

KW - Stem cells

U2 - 10.1007/978-981-13-9913-8_11

DO - 10.1007/978-981-13-9913-8_11

M3 - Book chapter

C2 - 31583592

AN - SCOPUS:85072936082

SN - 978-981-13-9912-1

T3 - Advances in Experimental Medicine and Biology

SP - 273

EP - 324

BT - Neuroglia in Neurodegenerative Diseases

A2 - Verkhratsky, Alexei

A2 - Ho, Margaret S.

A2 - Zorec, Robert

A2 - Parpura, Vladimir

PB - Springer

ER -

ID: 231241413