Astrocytes: integrators of arousal state and sensory context

Research output: Contribution to journal › Review › Research › peer-review

Standard

Astrocytes : integrators of arousal state and sensory context. / Rasmussen, Rune Nguyen; Asiminas, Antonis; Carlsen, Eva Maria Meier; Kjaerby, Celia; Smith, Nathan Anthony.

In: Trends in Neurosciences, Vol. 46, No. 6, 2023.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Rasmussen, RN, Asiminas, A, Carlsen, EMM, Kjaerby, C & Smith, NA 2023, 'Astrocytes: integrators of arousal state and sensory context', Trends in Neurosciences, vol. 46, no. 6. https://doi.org/10.1016/j.tins.2023.03.003

APA

Rasmussen, R. N., Asiminas, A., Carlsen, E. M. M., Kjaerby, C., & Smith, N. A. (2023). Astrocytes: integrators of arousal state and sensory context. Trends in Neurosciences, 46(6). https://doi.org/10.1016/j.tins.2023.03.003

Vancouver

Rasmussen RN, Asiminas A, Carlsen EMM, Kjaerby C, Smith NA. Astrocytes: integrators of arousal state and sensory context. Trends in Neurosciences. 2023;46(6). https://doi.org/10.1016/j.tins.2023.03.003

Author

Rasmussen, Rune Nguyen ; Asiminas, Antonis ; Carlsen, Eva Maria Meier ; Kjaerby, Celia ; Smith, Nathan Anthony. / Astrocytes : integrators of arousal state and sensory context. In: Trends in Neurosciences. 2023 ; Vol. 46, No. 6.

Bibtex

@article{f31655026f684f039c3d4eeaae869326,
title = "Astrocytes: integrators of arousal state and sensory context",
abstract = "The integration of external information with the internal state of the body is central to the survival of virtually every multicellular organism. However, a complete picture of the mechanisms that govern this process is lacking. In this opinion article, we synthesize evidence demonstrating that astrocytes sense the momentary arousal state – through neuromodulator release – as well as the sensory inputs – through local synaptic activity – and respond to them with changes in calcium (Ca2+) signaling. We hypothesize that astrocytes integrate sensory signals with the internal state and that this process is necessary to secure optimal behavior. Finally, we argue that dysfunctional astrocytic Ca2+ signaling could be an underlying factor in disorders characterized by disrupted sensory processing.",
keywords = "calcium signaling, glial cells, internal state, neuromodulation, sensory processing",
author = "Rasmussen, {Rune Nguyen} and Antonis Asiminas and Carlsen, {Eva Maria Meier} and Celia Kjaerby and Smith, {Nathan Anthony}",
note = "Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2023",
doi = "10.1016/j.tins.2023.03.003",
language = "English",
volume = "46",
journal = "Trends in Neurosciences",
issn = "0378-5912",
publisher = "Elsevier Ltd. * Trends Journals",
number = "6",

}

RIS

TY - JOUR

T1 - Astrocytes

T2 - integrators of arousal state and sensory context

AU - Rasmussen, Rune Nguyen

AU - Asiminas, Antonis

AU - Carlsen, Eva Maria Meier

AU - Kjaerby, Celia

AU - Smith, Nathan Anthony

N1 - Publisher Copyright: © 2023 The Authors

PY - 2023

Y1 - 2023

N2 - The integration of external information with the internal state of the body is central to the survival of virtually every multicellular organism. However, a complete picture of the mechanisms that govern this process is lacking. In this opinion article, we synthesize evidence demonstrating that astrocytes sense the momentary arousal state – through neuromodulator release – as well as the sensory inputs – through local synaptic activity – and respond to them with changes in calcium (Ca2+) signaling. We hypothesize that astrocytes integrate sensory signals with the internal state and that this process is necessary to secure optimal behavior. Finally, we argue that dysfunctional astrocytic Ca2+ signaling could be an underlying factor in disorders characterized by disrupted sensory processing.

AB - The integration of external information with the internal state of the body is central to the survival of virtually every multicellular organism. However, a complete picture of the mechanisms that govern this process is lacking. In this opinion article, we synthesize evidence demonstrating that astrocytes sense the momentary arousal state – through neuromodulator release – as well as the sensory inputs – through local synaptic activity – and respond to them with changes in calcium (Ca2+) signaling. We hypothesize that astrocytes integrate sensory signals with the internal state and that this process is necessary to secure optimal behavior. Finally, we argue that dysfunctional astrocytic Ca2+ signaling could be an underlying factor in disorders characterized by disrupted sensory processing.

KW - calcium signaling

KW - glial cells

KW - internal state

KW - neuromodulation

KW - sensory processing

U2 - 10.1016/j.tins.2023.03.003

DO - 10.1016/j.tins.2023.03.003

M3 - Review

C2 - 37003933

AN - SCOPUS:85151355816

VL - 46

JO - Trends in Neurosciences

JF - Trends in Neurosciences

SN - 0378-5912

IS - 6

ER -

ID: 342969991