An ocular glymphatic clearance system removes beta-amyloid from the rodent eye

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

An ocular glymphatic clearance system removes beta-amyloid from the rodent eye. / Wang, Xiaowei; Lou, Nanhong; Eberhardt, Allison; Yang, Yujia; Kusk, Peter; Xu, Qiwu; Forstera, Benjamin; Peng, Sisi; Shi, Meng; Ladron-de-Guevara, Antonio; Delle, Christine; Sigurdsson, Bjorn; Xavier, Anna L. R.; Erturk, Ali; Libby, Richard T.; Chen, Lu; Thrane, Alexander S.; Nedergaard, Maiken.

In: Science Translational Medicine, Vol. 12, No. 536, eaaw3210, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Wang, X, Lou, N, Eberhardt, A, Yang, Y, Kusk, P, Xu, Q, Forstera, B, Peng, S, Shi, M, Ladron-de-Guevara, A, Delle, C, Sigurdsson, B, Xavier, ALR, Erturk, A, Libby, RT, Chen, L, Thrane, AS & Nedergaard, M 2020, 'An ocular glymphatic clearance system removes beta-amyloid from the rodent eye', Science Translational Medicine, vol. 12, no. 536, eaaw3210. https://doi.org/10.1126/scitranslmed.aaw3210

APA

Wang, X., Lou, N., Eberhardt, A., Yang, Y., Kusk, P., Xu, Q., Forstera, B., Peng, S., Shi, M., Ladron-de-Guevara, A., Delle, C., Sigurdsson, B., Xavier, A. L. R., Erturk, A., Libby, R. T., Chen, L., Thrane, A. S., & Nedergaard, M. (2020). An ocular glymphatic clearance system removes beta-amyloid from the rodent eye. Science Translational Medicine, 12(536), [eaaw3210]. https://doi.org/10.1126/scitranslmed.aaw3210

Vancouver

Wang X, Lou N, Eberhardt A, Yang Y, Kusk P, Xu Q et al. An ocular glymphatic clearance system removes beta-amyloid from the rodent eye. Science Translational Medicine. 2020;12(536). eaaw3210. https://doi.org/10.1126/scitranslmed.aaw3210

Author

Wang, Xiaowei ; Lou, Nanhong ; Eberhardt, Allison ; Yang, Yujia ; Kusk, Peter ; Xu, Qiwu ; Forstera, Benjamin ; Peng, Sisi ; Shi, Meng ; Ladron-de-Guevara, Antonio ; Delle, Christine ; Sigurdsson, Bjorn ; Xavier, Anna L. R. ; Erturk, Ali ; Libby, Richard T. ; Chen, Lu ; Thrane, Alexander S. ; Nedergaard, Maiken. / An ocular glymphatic clearance system removes beta-amyloid from the rodent eye. In: Science Translational Medicine. 2020 ; Vol. 12, No. 536.

Bibtex

@article{8d25fa68afb9460898e2b0186d6edffa,
title = "An ocular glymphatic clearance system removes beta-amyloid from the rodent eye",
abstract = "Despite high metabolic activity, the retina and optic nerve head lack traditional lymphatic drainage. We here identified an ocular glymphatic clearance route for fluid and wastes via the proximal optic nerve in rodents. β-amyloid (Aβ) was cleared from the retina and vitreous via a pathway dependent on glial water channel aquaporin-4 (AQP4) and driven by the ocular-cranial pressure difference. After traversing the lamina barrier, intra-axonal Aβ was cleared via the perivenous space and subsequently drained to lymphatic vessels. Light-induced pupil constriction enhanced efflux, whereas atropine or raising intracranial pressure blocked efflux. In two distinct murine models of glaucoma, Aβ leaked from the eye via defects in the lamina barrier instead of directional axonal efflux. The results suggest that, in rodents, the removal of fluid and metabolites from the intraocular space occurs through a glymphatic pathway that might be impaired in glaucoma.",
author = "Xiaowei Wang and Nanhong Lou and Allison Eberhardt and Yujia Yang and Peter Kusk and Qiwu Xu and Benjamin Forstera and Sisi Peng and Meng Shi and Antonio Ladron-de-Guevara and Christine Delle and Bjorn Sigurdsson and Xavier, {Anna L. R.} and Ali Erturk and Libby, {Richard T.} and Lu Chen and Thrane, {Alexander S.} and Maiken Nedergaard",
year = "2020",
doi = "10.1126/scitranslmed.aaw3210",
language = "English",
volume = "12",
journal = "Science Translational Medicine",
issn = "1946-6234",
publisher = "american association for the advancement of science",
number = "536",

}

RIS

TY - JOUR

T1 - An ocular glymphatic clearance system removes beta-amyloid from the rodent eye

AU - Wang, Xiaowei

AU - Lou, Nanhong

AU - Eberhardt, Allison

AU - Yang, Yujia

AU - Kusk, Peter

AU - Xu, Qiwu

AU - Forstera, Benjamin

AU - Peng, Sisi

AU - Shi, Meng

AU - Ladron-de-Guevara, Antonio

AU - Delle, Christine

AU - Sigurdsson, Bjorn

AU - Xavier, Anna L. R.

AU - Erturk, Ali

AU - Libby, Richard T.

AU - Chen, Lu

AU - Thrane, Alexander S.

AU - Nedergaard, Maiken

PY - 2020

Y1 - 2020

N2 - Despite high metabolic activity, the retina and optic nerve head lack traditional lymphatic drainage. We here identified an ocular glymphatic clearance route for fluid and wastes via the proximal optic nerve in rodents. β-amyloid (Aβ) was cleared from the retina and vitreous via a pathway dependent on glial water channel aquaporin-4 (AQP4) and driven by the ocular-cranial pressure difference. After traversing the lamina barrier, intra-axonal Aβ was cleared via the perivenous space and subsequently drained to lymphatic vessels. Light-induced pupil constriction enhanced efflux, whereas atropine or raising intracranial pressure blocked efflux. In two distinct murine models of glaucoma, Aβ leaked from the eye via defects in the lamina barrier instead of directional axonal efflux. The results suggest that, in rodents, the removal of fluid and metabolites from the intraocular space occurs through a glymphatic pathway that might be impaired in glaucoma.

AB - Despite high metabolic activity, the retina and optic nerve head lack traditional lymphatic drainage. We here identified an ocular glymphatic clearance route for fluid and wastes via the proximal optic nerve in rodents. β-amyloid (Aβ) was cleared from the retina and vitreous via a pathway dependent on glial water channel aquaporin-4 (AQP4) and driven by the ocular-cranial pressure difference. After traversing the lamina barrier, intra-axonal Aβ was cleared via the perivenous space and subsequently drained to lymphatic vessels. Light-induced pupil constriction enhanced efflux, whereas atropine or raising intracranial pressure blocked efflux. In two distinct murine models of glaucoma, Aβ leaked from the eye via defects in the lamina barrier instead of directional axonal efflux. The results suggest that, in rodents, the removal of fluid and metabolites from the intraocular space occurs through a glymphatic pathway that might be impaired in glaucoma.

U2 - 10.1126/scitranslmed.aaw3210

DO - 10.1126/scitranslmed.aaw3210

M3 - Journal article

C2 - 32213628

VL - 12

JO - Science Translational Medicine

JF - Science Translational Medicine

SN - 1946-6234

IS - 536

M1 - eaaw3210

ER -

ID: 239301378