Air pollution, glymphatic impairment, and Alzheimer's disease

Research output: Contribution to journal › Review › Research › peer-review

Standard

Air pollution, glymphatic impairment, and Alzheimer's disease. / Hussain, Rashad; Graham, Uschi; Elder, Alison; Nedergaard, Maiken.

In: Trends in Neurosciences, Vol. 46, No. 11, 2023, p. 901-911.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Hussain, R, Graham, U, Elder, A & Nedergaard, M 2023, 'Air pollution, glymphatic impairment, and Alzheimer's disease', Trends in Neurosciences, vol. 46, no. 11, pp. 901-911. https://doi.org/10.1016/j.tins.2023.08.010

APA

Hussain, R., Graham, U., Elder, A., & Nedergaard, M. (2023). Air pollution, glymphatic impairment, and Alzheimer's disease. Trends in Neurosciences, 46(11), 901-911. https://doi.org/10.1016/j.tins.2023.08.010

Vancouver

Hussain R, Graham U, Elder A, Nedergaard M. Air pollution, glymphatic impairment, and Alzheimer's disease. Trends in Neurosciences. 2023;46(11):901-911. https://doi.org/10.1016/j.tins.2023.08.010

Author

Hussain, Rashad ; Graham, Uschi ; Elder, Alison ; Nedergaard, Maiken. / Air pollution, glymphatic impairment, and Alzheimer's disease. In: Trends in Neurosciences. 2023 ; Vol. 46, No. 11. pp. 901-911.

Bibtex

@article{7e34742a67ab4bc8af1a0b3a23d360a9,
title = "Air pollution, glymphatic impairment, and Alzheimer's disease",
abstract = "Epidemiological evidence demonstrates a link between air pollution exposure and the onset and progression of cognitive impairment and Alzheimer's disease (AD). However, current understanding of the underlying pathophysiological mechanisms is limited. This opinion article examines the hypothesis that air pollution-induced impairment of glymphatic clearance represents a crucial etiological event in the development of AD. Exposure to airborne particulate matter (PM) leads to systemic inflammation and neuroinflammation, increased metal load, respiratory and cardiovascular dysfunction, and sleep abnormalities. All these factors are known to reduce the efficiency of glymphatic clearance. Rescuing glymphatic function by restricting the impact of causative agents, and improving sleep and cardiovascular system health, may increase the efficiency of waste metabolite clearance and subsequently slow the progression of AD. In sum, we introduce air pollution-mediated glymphatic impairment as an important mechanistic factor to be considered when interpreting the etiology and progression of AD as well as its responsiveness to therapeutic interventions.",
keywords = "aging, amyloid plaques, CSF, neurodegeneration, ultrafine particles",
author = "Rashad Hussain and Uschi Graham and Alison Elder and Maiken Nedergaard",
note = "Publisher Copyright: {\textcopyright} 2023",
year = "2023",
doi = "10.1016/j.tins.2023.08.010",
language = "English",
volume = "46",
pages = "901--911",
journal = "Trends in Neurosciences",
issn = "0378-5912",
publisher = "Elsevier Ltd. * Trends Journals",
number = "11",

}

RIS

TY - JOUR

T1 - Air pollution, glymphatic impairment, and Alzheimer's disease

AU - Hussain, Rashad

AU - Graham, Uschi

AU - Elder, Alison

AU - Nedergaard, Maiken

N1 - Publisher Copyright: © 2023

PY - 2023

Y1 - 2023

N2 - Epidemiological evidence demonstrates a link between air pollution exposure and the onset and progression of cognitive impairment and Alzheimer's disease (AD). However, current understanding of the underlying pathophysiological mechanisms is limited. This opinion article examines the hypothesis that air pollution-induced impairment of glymphatic clearance represents a crucial etiological event in the development of AD. Exposure to airborne particulate matter (PM) leads to systemic inflammation and neuroinflammation, increased metal load, respiratory and cardiovascular dysfunction, and sleep abnormalities. All these factors are known to reduce the efficiency of glymphatic clearance. Rescuing glymphatic function by restricting the impact of causative agents, and improving sleep and cardiovascular system health, may increase the efficiency of waste metabolite clearance and subsequently slow the progression of AD. In sum, we introduce air pollution-mediated glymphatic impairment as an important mechanistic factor to be considered when interpreting the etiology and progression of AD as well as its responsiveness to therapeutic interventions.

AB - Epidemiological evidence demonstrates a link between air pollution exposure and the onset and progression of cognitive impairment and Alzheimer's disease (AD). However, current understanding of the underlying pathophysiological mechanisms is limited. This opinion article examines the hypothesis that air pollution-induced impairment of glymphatic clearance represents a crucial etiological event in the development of AD. Exposure to airborne particulate matter (PM) leads to systemic inflammation and neuroinflammation, increased metal load, respiratory and cardiovascular dysfunction, and sleep abnormalities. All these factors are known to reduce the efficiency of glymphatic clearance. Rescuing glymphatic function by restricting the impact of causative agents, and improving sleep and cardiovascular system health, may increase the efficiency of waste metabolite clearance and subsequently slow the progression of AD. In sum, we introduce air pollution-mediated glymphatic impairment as an important mechanistic factor to be considered when interpreting the etiology and progression of AD as well as its responsiveness to therapeutic interventions.

KW - aging

KW - amyloid plaques

KW - CSF

KW - neurodegeneration

KW - ultrafine particles

U2 - 10.1016/j.tins.2023.08.010

DO - 10.1016/j.tins.2023.08.010

M3 - Review

C2 - 37777345

AN - SCOPUS:85172861987

VL - 46

SP - 901

EP - 911

JO - Trends in Neurosciences

JF - Trends in Neurosciences

SN - 0378-5912

IS - 11

ER -

ID: 371286861