Age- and glaucoma-induced changes to the ocular glymphatic system

Research output: Contribution to journal › Journal article › Research › peer-review

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Age- and glaucoma-induced changes to the ocular glymphatic system. / Wang, Xiaowei; Delle, Christine; Peng, Weiguo; Plá, Virginia; Giannetto, Michael; Kusk, Peter; Sigurdsson, Björn; Sakurai, Shinya; Sweeney, Amanda; Sun, Qian; Du, Ting; Libby, Richard T.; Nedergaard, Maiken.

In: Neurobiology of Disease, Vol. 188, 106322, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Wang, X, Delle, C, Peng, W, Plá, V, Giannetto, M, Kusk, P, Sigurdsson, B, Sakurai, S, Sweeney, A, Sun, Q, Du, T, Libby, RT & Nedergaard, M 2023, 'Age- and glaucoma-induced changes to the ocular glymphatic system', Neurobiology of Disease, vol. 188, 106322. https://doi.org/10.1016/j.nbd.2023.106322

APA

Wang, X., Delle, C., Peng, W., Plá, V., Giannetto, M., Kusk, P., Sigurdsson, B., Sakurai, S., Sweeney, A., Sun, Q., Du, T., Libby, R. T., & Nedergaard, M. (2023). Age- and glaucoma-induced changes to the ocular glymphatic system. Neurobiology of Disease, 188, [106322]. https://doi.org/10.1016/j.nbd.2023.106322

Vancouver

Wang X, Delle C, Peng W, Plá V, Giannetto M, Kusk P et al. Age- and glaucoma-induced changes to the ocular glymphatic system. Neurobiology of Disease. 2023;188. 106322. https://doi.org/10.1016/j.nbd.2023.106322

Author

Wang, Xiaowei ; Delle, Christine ; Peng, Weiguo ; Plá, Virginia ; Giannetto, Michael ; Kusk, Peter ; Sigurdsson, Björn ; Sakurai, Shinya ; Sweeney, Amanda ; Sun, Qian ; Du, Ting ; Libby, Richard T. ; Nedergaard, Maiken. / Age- and glaucoma-induced changes to the ocular glymphatic system. In: Neurobiology of Disease. 2023 ; Vol. 188.

Bibtex

@article{60cb521740384f1b88e1fab0ffbcea02,
title = "Age- and glaucoma-induced changes to the ocular glymphatic system",
abstract = "The ocular glymphatic system supports bidirectional fluid transport along the optic nerve, thereby removes metabolic wastes including amyloid-β. To better understand this biological process, we examined the distributions of intravitreally and intracisternally infused tracers in full-length optic nerves from different age groups of mice. Aging was linked to globally impaired ocular glymphatic fluid transport, similar to what has seen previously in the brain. Aging also reduced the pupillary responsiveness to light stimulation and abolished light-induced facilitation in anterograde ocular glymphatic flow. In contrast to normal aging, in the DBA/2 J model of glaucoma, we found a pathological increase of glymphatic fluid transport to the anterior optic nerve that was associated with dilation of the perivascular spaces. Thus, aging and glaucoma have fundamentally different effects on ocular glymphatic fluid transport. Manipulation of glymphatic fluid transport might therefore present a new target for the treatment of glaucoma.",
keywords = "Enlarged perivascular space, glaucoma, Ocular aging, Ocular glymphatic system",
author = "Xiaowei Wang and Christine Delle and Weiguo Peng and Virginia Pl{\'a} and Michael Giannetto and Peter Kusk and Bj{\"o}rn Sigurdsson and Shinya Sakurai and Amanda Sweeney and Qian Sun and Ting Du and Libby, {Richard T.} and Maiken Nedergaard",
note = "Publisher Copyright: {\textcopyright} 2023",
year = "2023",
doi = "10.1016/j.nbd.2023.106322",
language = "English",
volume = "188",
journal = "Neurobiology of Disease",
issn = "0969-9961",
publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - Age- and glaucoma-induced changes to the ocular glymphatic system

AU - Wang, Xiaowei

AU - Delle, Christine

AU - Peng, Weiguo

AU - Plá, Virginia

AU - Giannetto, Michael

AU - Kusk, Peter

AU - Sigurdsson, Björn

AU - Sakurai, Shinya

AU - Sweeney, Amanda

AU - Sun, Qian

AU - Du, Ting

AU - Libby, Richard T.

AU - Nedergaard, Maiken

N1 - Publisher Copyright: © 2023

PY - 2023

Y1 - 2023

N2 - The ocular glymphatic system supports bidirectional fluid transport along the optic nerve, thereby removes metabolic wastes including amyloid-β. To better understand this biological process, we examined the distributions of intravitreally and intracisternally infused tracers in full-length optic nerves from different age groups of mice. Aging was linked to globally impaired ocular glymphatic fluid transport, similar to what has seen previously in the brain. Aging also reduced the pupillary responsiveness to light stimulation and abolished light-induced facilitation in anterograde ocular glymphatic flow. In contrast to normal aging, in the DBA/2 J model of glaucoma, we found a pathological increase of glymphatic fluid transport to the anterior optic nerve that was associated with dilation of the perivascular spaces. Thus, aging and glaucoma have fundamentally different effects on ocular glymphatic fluid transport. Manipulation of glymphatic fluid transport might therefore present a new target for the treatment of glaucoma.

AB - The ocular glymphatic system supports bidirectional fluid transport along the optic nerve, thereby removes metabolic wastes including amyloid-β. To better understand this biological process, we examined the distributions of intravitreally and intracisternally infused tracers in full-length optic nerves from different age groups of mice. Aging was linked to globally impaired ocular glymphatic fluid transport, similar to what has seen previously in the brain. Aging also reduced the pupillary responsiveness to light stimulation and abolished light-induced facilitation in anterograde ocular glymphatic flow. In contrast to normal aging, in the DBA/2 J model of glaucoma, we found a pathological increase of glymphatic fluid transport to the anterior optic nerve that was associated with dilation of the perivascular spaces. Thus, aging and glaucoma have fundamentally different effects on ocular glymphatic fluid transport. Manipulation of glymphatic fluid transport might therefore present a new target for the treatment of glaucoma.

KW - Enlarged perivascular space

KW - glaucoma

KW - Ocular aging

KW - Ocular glymphatic system

U2 - 10.1016/j.nbd.2023.106322

DO - 10.1016/j.nbd.2023.106322

M3 - Journal article

C2 - 37832797

AN - SCOPUS:85174208630

VL - 188

JO - Neurobiology of Disease

JF - Neurobiology of Disease

SN - 0969-9961

M1 - 106322

ER -

ID: 371286658