- 2022
- Published
Posthemorrhagic hydrocephalus associates with elevated inflammation and CSF hypersecretion via activation of choroidal transporters
Lolansen, Sara Diana, Rostgaard, Nina, Barbuskaite, Dagne, Capion, T., Olsen, M. H., Norager, N. H., Vilhardt, Frederik, Andreassen, Søren Norge, Toft-Bertelsen, Trine Lisberg, Ye, F., Juhler, Marianne, Keep, R. F. & MacAulay, Nanna, 2022, In: Fluids and Barriers of the CNS. 19, 1, 19 p., 62.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pretargeted Imaging beyond the Blood–Brain Barrier: Utopia or Feasible?
Lopes van den Broek, S., Shalgunov, Vladimir, García Vázquez, R., Beschorner, Natalie, Bidesi, N. S. R., Nedergaard, Maiken, Knudsen, Gitte Moos, Sehlin, D., Syvänen, S. & Herth, Matthias Manfred, 2022, In: Pharmaceuticals. 15, 10, 13 p., 1191.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Psilocybin-induced reduction in chronic cluster headache attack frequency correlates with changes in hypothalamic functional connectivity
Madsen, M. K., Petersen, A. S., Stenbæk, Dea Siggaard, Sorensen, I. M., Schionning, H., Fjeld, T., Nykjaer, C., Larsen, S. M. U., Grzywacz, M., Mathiesen, T., Klausen, I., Hansen, O. O., Brendstrup-Brix, K., Linnet, Kristian, Johansen, Sys Stybe, Fisher, P. M., Jensen, Rasmus Herlo Beenfeldt, Knudsen, Gitte Moos & Madsen, M. K., 2022, medRxiv, 17 p.Research output: Working paper › Preprint › Research
- Published
SPECT/CT imaging reveals CNS-wide modulation of glymphatic cerebrospinal fluid flow by systemic hypertonic saline
Lilius, T. O., Rosenholm, Marko, Klinger, L., Mortensen, K. N., Sigurdsson, B., Mogensen, F. L., Hauglund, Natalie Linea, Nielsen, Malthe Skytte Nordentoft, Rantamaki, T. & Nedergaard, Maiken, 2022, In: iScience. 25, 10, 17 p., 105250.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
SpAD Biofunctionalized Cellulose Acetate Scaffolds Inhibit Staphylococcus aureus Adherence in a Coordinating Function with the von Willebrand A1 Domain (vWF A1)
Pendas, S., Asiminas, Antonios, Katranidis, A., Tsioptsias, C., Pitou, M., Papadopoulos, G. & Choli-Papadopoulou, T., 2022, In: Journal of Functional Biomaterials. 13, 17 p., 21.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Systemic hypertonic saline enhances glymphatic spinal cord delivery of lumbar intrathecal morphine
Blomqvist, K. J., Skogster, M. O. B., Kurkela, M. J., Rosenholm, Marko, Ahlström, F. H. G., Airavaara, M. T., Backman, J. T., Rauhala, P. V., Kalso, E. A. & Lilius, T. O., 2022, In: Journal of Controlled Release. 344, p. 214-224 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
TUBE project: Transport-derived ultrafines and the brain effects
Martikainen, M. V., Aakko-Saksa, P., Broek, L. V. D., Cassee, F. R., Carare, R. O., Chew, S., Dinnyes, A., Giugno, R., Kanninen, K. M., Malm, T., Muala, A., Nedergaard, M., Oudin, A., Oyola, P., Pfeiffer, T. V., Rönkkö, T., Saarikoski, S., Sandström, T., Schins, R. P. F., Topinka, J. & 4 others, , 2022, In: International Journal of Environmental Research and Public Health. 19, 1, 14 p., 311.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Acute and Chronic Effects of Acetazolamide and Topiramate on Intracranial Pressure and CSF Secretion
Westgate, C., Kamp-Jensen, C., Israelsen, I., Toft-Bertelsen, Trine Lisberg, Wardman, Jonathan Henry, Jensen, C., Styrishave, Bjarne, MacAulay, Nanna, Jensen, Rasmus Herlo Beenfeldt & Eftekhari, S., 2022, In: Journal of Headache and Pain. 23, Suppl. 1, 1 p., P218.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
The Effect of Hyperoxia on Central and Peripheral Factors of Arm Flexor Muscles Fatigue Following Maximal Ergometer Rowing in Men
Volianitis, S., Rasmussen, P., Petersen, Nicolas Caesar & Secher, Niels H., 2022, In: Frontiers in Physiology. 13, 10 p., 829097.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The association of anxiety and other clinical features with CACNA1C rs1006737 in patients with depression
Dam, H., Buch, J. O. D., Nielsen, A. B., Weikop, Pia & Jørgensen, Martin Balslev, 2022, In: Translational Neuroscience. 13, 1, p. 320-326 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effect of long-duration spaceflight on perivascular spaces within the brain
Wostyn, P., Mader, T. H., Gibson, C. R. & Nedergaard, Maiken, 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 32, 1 p., e2207724119.Research output: Contribution to journal › Letter › Research › peer-review
- Published
The elusive varicose astrocytes
Rasmussen, R. N. & Smith, N. A., 2022, In: Trends in Neurosciences. 45, 2, p. 94-95 2 p.Research output: Contribution to journal › Comment/debate › Research
- Published
The glymphatic system: implications for drugs for central nervous system diseases
Lohela, T. J., Lilius, T. O. & Nedergaard, Maiken, 2022, In: Nature Reviews Drug Discovery. 21, 10, p. 763-779 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The glymphatic system: Current understanding and modeling
Bohr, T., Hjorth, P. G., Holst, S. C., Hrabětová, S., Kiviniemi, V., Lilius, T., Lundgaard, I., Mardal, K. A., Martens, E. A., Mori, Yuki, Nägerl, U. V., Nicholson, C., Tannenbaum, A., Thomas, J. H., Tithof, J., Benveniste, H., Iliff, J. J., Kelley, D. H. & Nedergaard, Maiken, 2022, In: iScience. 25, 9, 33 p., 104987.Research output: Contribution to journal › Review › Research › peer-review
- Published
The role of central serotonergic markers and estradiol changes in perinatal mental health
Borgsted, C., Høgh, S., Høgsted, E. S., Fonnesbech-Sandberg, L., Ekelund, Kim, Albrechtsen, C. K., Wiis, J. T., Hegaard, Hanne Kristine, Cvetanovska, E., Juul, Anders, Frederiksen, H., Pinborg, Anja, Weikop, Pia & Frøkjær, Vibe Gedsø, 2022, In: Acta Psychiatrica Scandinavica. 146, 4, p. 357-369 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Translating cell therapies for neurodegenerative diseases: Huntington's disease as a model disorder
Rosser, A. E., Busse, M. E., Gray, W. P., Badin, R. A., Perrier, A. L., Wheelock, V., Cozzi, E., Martin, U. P., Salado-Manzano, C., Mills, L. J., Drew, C., Goldman, Steven Alan, Canals, J. M., Thompson, L. M. & SC4HD Members, S. M., 2022, In: Brain. 145, 5, p. 1584-1597 14 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Validation of ultrasonography for measurement of cartilage thickness in the equine carpus
Andersen, Camilla, Griffin, J. F., Jacobsen, Stine, Østergaard, Stine, Walters, M., Mori, Yuki & Lindegaard, Casper, 2022, In: Veterinary Radiology & Ultrasound. 63, 4, p. 478-489 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Versatile treadmill system for measuring locomotion and neural activity in head-fixed mice
Carlsen, Eva Maria Meier, Nedergaard, Maiken & Rasmussen, R. N., 2022, In: STAR Protocols. 3, 4, 14 p., 101701.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Using crystallography tools to improve vaccine formulations
de Abreu Fantini, M. C., Pinto Oliveira, C. L., de Souza Lopes, J. L., Martins, T. D. S., Akamatsu, M. A., Trezena, A. G., Tino-De-Franco, M., Botosso, V. F., Brazil Esteves Sant'Anna, O. A., Kardjilov, N., Rasmussen, Martin Kaag & Nunes Bordallo, Heloisa, 1 Jan 2022, In: IUCrJ. 9, p. 11-20 14 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Single cell mapping the evolution of the spatial processing centre within the brain
Ralbovszki, Dorottya Maria, Bertelsen, Mads Frost, Buchmann, Kurt, Mori, Yuki, Gorodkin, Jan, Hemberg, M., Seemann, Ernst Stefan, Khodosevich, Konstantin & Hall, Vanessa Jane, 1 May 2022.Research output: Contribution to conference › Poster › Communication
- 2023
- Published
A SPECT-based method for dynamic imaging of the glymphatic system in rats
Sigurdsson, B., Hauglund, Natalie Linea, Lilius, T. O., Mogensen, F. L. H., Mortensen, K. N., Beschorner, Natalie, Klinger, L., Bærentzen, S. L., Rosenholm, Marko, Shalgunov, Vladimir, Herth, Matthias Manfred, Mori, Yuki & Nedergaard, Maiken, 2023, In: Journal of Cerebral Blood Flow and Metabolism. 43, 7, 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A mesothelium divides the subarachnoid space into functional compartments
Møllgård, Kjeld, Beinlich, Felix Ralf Michael, Kusk, P., Miyakoshi, L. M., Delle, Christine, Pla Requena, Virginia Teresa, Hauglund, Natalie Linea, Esmail, Tina, Rasmussen, Martin Kaag, Gomolka, Ryszard Stefan, Mori, Yuki & Nedergaard, Maiken, 2023, In: Science. 379, 6627, p. 84-885Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A sensitive and specific genetically-encoded potassium ion biosensor for in vivo applications across the tree of life
Wu, S-Y., Wen, Y., Serre, N. B. C., Laursen, C. C. H., Dietz, A. G., Taylor, B. R., Drobizhev, M., Molina, R. S., Aggarwal, A., Rancic, V., Becker, M., Ballanyi, K., Podgorski, K., Hirase, H., Nedergaard, M., Fendrych, M., Lemieux, M. J., Eberl, D. F., Kay, A. R., Campbell, R. E. & 1 others, , 2023, In: PLOS Biology. 20, 9, 23 p., e3001772.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Age- and glaucoma-induced changes to the ocular glymphatic system
Wang, X., Delle, Christine, Peng, W., Pla Requena, Virginia Teresa, Giannetto, M., Kusk, P., Sigurdsson, B., Sakurai, S., Sweeney, A., Sun, Q., Du, Ting, Libby, R. T. & Nedergaard, Maiken, 2023, In: Neurobiology of Disease. 188, 9 p., 106322.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Air pollution, glymphatic impairment, and Alzheimer's disease
Hussain, R., Graham, U., Elder, A. & Nedergaard, Maiken, 2023, In: Trends in Neurosciences. 46, 11, p. 901-911 11 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Astrocyte endfeet may theoretically act as valves to convert pressure oscillations to glymphatic flow
Bork, Peter Aleksander Rousing, Ladrón-De-Guevara, A., Christensen, A. H., Jensen, K. H., Nedergaard, Maiken & Bohr, T., 2023, In: Journal of the Royal Society Interface. 20, 204, 5 p., 20230050.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Astrocytes: integrators of arousal state and sensory context
Rasmussen, R. N., Asiminas, Antonios, Carlsen, Eva Maria Meier, Kjærby, Celia & Smith, N. A., 2023, In: Trends in Neurosciences. 46, 6, 8 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Astrocytes as master modulators of neural networks: Synaptic functions and disease-associated dysfunction of astrocytes
Stogsdill, J. A., Harwell, C. C. & Goldman, Steven Alan, 2023, In: Annals of the New York Academy of Sciences. 1525, 1, p. 41-60 20 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Astrocytic GPCR-Induced Ca2+ Signaling Is Not Causally Related to Local Cerebral Blood Flow Changes
Ozawa, K., Nagao, Masaki, Konno, A., Iwai, Y., Vittani, Marta, Kusk, P., Mishima, Tsuneko, Hirai, H., Nedergaard, Maiken & Hirase, Hajime, 2023, In: International Journal of Molecular Sciences. 24, 17, 12 p., 13590.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Astrocytic chloride is brain state dependent and modulates inhibitory neurotransmission in mice
Untiet, Verena, Beinlich, Felix Ralf Michael, Kusk, P., Kang, N., Ladrón-de-Guevara, A., Song, W., Kjærby, Celia, Andersen, Mie, Hauglund, Natalie Linea, Bojarowska, Zuzanna, Sigurdsson, B., Deng, S., Hirase, Hajime, Petersen, Nicolas Caesar, Verkhratsky, A. & Nedergaard, Maiken, 2023, In: Nature Communications. 14, 1, 14 p., 1871.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Astrocytic contributions to Huntington's disease pathophysiology
Khakh, B. S. & Goldman, Steven Alan, 2023, In: Annals of the New York Academy of Sciences. 1522, 1, p. 42-59 18 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Astrocytic engagement of the corticostriatal synaptic cleft is disrupted in a mouse model of Huntington’s disease
Villanueva, C. B., Stephensen, Hans Jacob Teglbjærg, Mokso, R., Benraiss, A., Sporring, Jon & Goldman, Steven Alan, 2023, In: Proceedings of the National Academy of Sciences USA (PNAS). 120, 24, 11 p., e2210719120.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Behavioral and biochemical effects of alcohol withdrawal in female C3H/HeNRj and C57BL/6JRj mice
Tonetto, S., Weikop, Pia, Brudek, T. & Thomsen, M., 2023, In: Frontiers in Behavioral Neuroscience. 17, 18 p., 1143720.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Blood–brain barrier permeable β-blockers linked to lower risk of Alzheimer’s disease in hypertension
Beaman, Emily Eufaula, Bonde, A. N., Larsen, S. M. U., Ozenne, Brice Maxime Hugues, Lohela, T. J., Nedergaard, Maiken, Gislason, Gunnar Hilmar, Knudsen, Gitte Moos & Holst, S. C., 2023, In: Brain. 146, 3, p. 1141–1151 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Brain-specific glycosylation of protein tyrosine phosphatase receptor type Z (PTPRZ) marks a demyelination-associated astrocyte subtype
Takahashi, K., Kanekiyo, K., Sakuda, K., Muto, Y., Iguchi, M., Matsuda, N., Hashimoto, Y., Kanai, K., Ogawa, H., Hirase, Hajime, Kakita, A., Bizen, N., Takebayashi, H., Kawaguchi, Y., Uzuki, M. & Kitazume, S., 2023, In: Journal of Neurochemistry. 166, 3, 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Delivery of gene therapy through a cerebrospinal fluid conduit to rescue hearing in adult mice
Mathiesen, B. K., Miyakoshi, L. M., Cederroth, C. R., Tserga, E., Versteegh, C., Bork, Peter Aleksander Rousing, Hauglund, Natalie Linea, Gomolka, Ryszard Stefan, Mori, Yuki, Edvall, N. K., Rouse, S., Møllgård, Kjeld, Holt, J. R., Nedergaard, Maiken & Canlon, B., 2023, In: Science Translational Medicine. 15, 702, 13 p., eabq3916.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development of 11C-labeled CRANAD-102 for positron emission tomography imaging of soluble Aβ-species
Staudt, Markus, Shalgunov, Vladimir, Nedergaard, Maiken & Herth, Matthias Manfred, 2023, In: Journal of Labelled Compounds and Radiopharmaceuticals. 66, 12, p. 393-399Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Early impairments of visually-driven neuronal ensemble dynamics in the rTg4510 tauopathy mouse model
Parka, A., Degel, C., Dreyer, J., Richter, U., Hall, B., Bastlund, J. F., Laursen, B., Nedergaard, Maiken, Sotty, F. & Botta, P., 2023, In: Neurobiology of Disease. 178, 13 p., 106012.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of sleep deprivation and NREM sleep stage on physiological brain pulsations
Helakari, H., Järvelä, M., Väyrynen, T., Tuunanen, J., Piispala, J., Kallio, M., Ebrahimi, S. M., Poltojainen, V., Kananen, J., Elabasy, A., Huotari, N., Raitamaa, L., Tuovinen, T., Korhonen, V., Nedergaard, Maiken & Kiviniemi, V., 2023, In: Frontiers in Neuroscience. 17, 17 p., 1275184.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glial progenitor cells of the adult human white and grey matter are contextually distinct
Osorio, M. J., Mariani, J. N., Zou, L., Schanz, S. J., Heffernan, K., Cornwell, A. & Goldman, Steven Alan, 2023, In: Glia. 71, 3, p. 524-540 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glymphatic influx and clearance are accelerated by neurovascular coupling: [Inkl. Correction]
Holstein-Rønsbo, Stephanie, Gan, Y., Giannetto, M. J., Rasmussen, Martin Kaag, Sigurdsson, B., Beinlich, Felix Ralf Michael, Rose, Laura, Untiet, Verena, Hablitz, L. M., Kelley, D. H. & Nedergaard, Maiken, 2023, In: Nature Neuroscience. 26, p. 1042–1053Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glymphatic-assisted perivascular brain delivery of intrathecal small gold nanoparticles
Lilius, T. O., Mortensen, K. N., Deville, C., Lohela, T. J., Stæger, Frederik Filip Vinggaard, Sigurdsson, B., Fiordaliso, E. M., Rosenholm, Marko, Kamphuis, C., Beekman, F. J., Jensen, A. I. & Nedergaard, Maiken, 2023, In: Journal of Controlled Release. 355, p. 135-148 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Insulin-like growth factor 1 supplementation supports motor coordination and affects myelination in preterm pigs
Christiansen, Line Iadsatian, Ventura, G. C., Holmqvist, B., Aasmul-Olsen, Karoline, Lindholm, S. E. H., Lycas, M. D., Mori, Yuki, Secher, Jan Bojsen-Møller, Burrin, D. G., Thymann, Thomas, Sangild, Per Torp & Pankratova, Stanislava, 2023, In: Frontiers in Neuroscience. 17, 15 p., 1205819.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ketamine reduces electrophysiological network activity in cortical neuron cultures already at sub-micromolar concentrations – Impact on TrkB-ERK1/2 signaling
Ahtiainen, A., Annala, I., Rosenholm, Marko, Kohtala, S., Hyttinen, J., Tanskanen, J. M. A. & Rantamäki, T., 2023, In: Neuropharmacology. 229, 11 p., 109481.Research output: Contribution to journal › Review › Research › peer-review
- Published
Lactate biosensors for spectrally and spatially multiplexed fluorescence imaging
Nasu, Y., Aggarwal, A., Le, G. N. T., Vo, C. T., Kambe, Y., Wang, X., Beinlich, F. R. M., Lee, A. B., Ram, T. R., Wang, F., Gorzo, K. A., Kamijo, Y., Boisvert, M., Nishinami, S., Kawamura, G., Ozawa, T., Toda, H., Gordon, G. R., Ge, S., Hirase, H. & 5 others, , 2023, In: Nature Communications. 14, 1, 17 p., 6598.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Local extracellular K+ in cortex regulates norepinephrine levels, network state, and behavioral output
Dietz, Andrea Grostøl, Weikop, Pia, Hauglund, Natalie Linea, Andersen, Mie, Petersen, Nicolas Caesar, Rose, Laura, Hirase, Hajime & Nedergaard, Maiken, 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 40, 9 p., e2305071120.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Locomotion Induces Fundamentally Different Patterns of Ca2+Signaling in Astrocytes and Neurons
Hirase, Hajime & Nedergaard, Maiken, 2023, In: Function. 4, 4, 2 p., zqad028.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Long-term high-fat diet increases glymphatic activity in the hypothalamus in mice
Delle, Christine, Cankar, Neza, Digebjerg Holgersson, C., Hvorup Knudsen, H., Nielsen, Elise Schiøler, Kjærby, Celia, Mori, Yuki, Nedergaard, Maiken & Weikop, Pia, 2023, In: Scientific Reports. 13, 1, 11 p., 4137.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation
Gomolka, Ryszard Stefan, Hablitz, L. M., Mestre, H., Giannetto, M., Du, Ting, Hauglund, Natalie Linea, Xie, L., Peng, W., Martinez, P. M., Nedergaard, Maiken & Mori, Yuki, 2023, In: eLife. 12, 36 p., e82232.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Perivascular pumping of cerebrospinal fluid in the brain with a valve mechanism
Gan, Y., Holstein-Rønsbo, Stephanie, Nedergaard, Maiken, Boster, K. A. S., Thomas, J. H. & Kelley, D. H., 2023, In: Journal of the Royal Society, Interface. 20, 206, 17 p., 20230288.Research output: Contribution to journal › Journal article › Research › peer-review
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SPECT imaging of the glymphatic pathway with In-111-labeled ovalbumin in the rat brain
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In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy
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Understanding the functions and relationships of the glymphatic system and meningeal lymphatics
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Remyelination in the Central Nervous System
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Glymphatic fluid transport is suppressed by the aquaporin-4 inhibitor AER-271
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The glymphatic system and Amyotrophic lateral sclerosis
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