Center for Translational Neuromedicine

  1. Published

    Editorial: Role of Astrocytes in Seizures Induced by Traumatic Brain Injury

    Wang, F., Pan, F., Hirase, Hajime & Huang, J. H., 2020, In: Frontiers in Neurology. 11, 604788.

    Research output: Contribution to journalEditorialResearchpeer-review

  2. Published

    Astrocytic connexin 43 potentiates myelin injury in ischemic white matter disease

    Wang, M., Qin, C., Luo, X., Wang, J., Wang, X., Xie, M., Hu, J., Cao, J., Hu, T., Goldman, Steven Alan, Nedergaard, Maiken & Wang, W., 2019, In: Theranostics. 9, 15, p. 4474-4493 20 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts

    Wang, M., Ding, F., Deng, S., Guo, X., Wang, W., Iliff, J. J. & Nedergaard, Maiken, 15 Mar 2017, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 37, 11, p. 2870-2877 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    An ocular glymphatic clearance system removes beta-amyloid from the rodent eye

    Wang, X., Lou, N., Eberhardt, A., Yang, Y., Kusk, P., Xu, Q., Forstera, B., Peng, S., Shi, M., Ladron-de-Guevara, A., Delle, Christine, Sigurdsson, B., L R Xavier, Anna , Erturk, A., Libby, R. T., Chen, L., Thrane, A. S. & Nedergaard, Maiken, 2020, In: Science Translational Medicine. 12, 536, eaaw3210.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Age- and glaucoma-induced changes to the ocular glymphatic system

    Wang, X., Delle, Christine, Peng, W., Pla Requena, Virginia Teresa, Giannetto, M., Kusk, P., Sigurdsson, B., Sakurai, S., Sweeney, A., Sun, Q., Du, Ting, Libby, R. T. & Nedergaard, Maiken, 2023, In: Neurobiology of Disease. 188, 9 p., 106322.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    The Ocular Glymphatic Clearance System

    Wang, X., Lou, N., Eberhardt, A., Jørgensen, P. K., Xu, Q., Foerstera, B., Peng, S., Yang, Y., Shi, M., L R Xavier, Anna , Ertürk, A., Libby, R. T., Lu, C., Thrane, A. & Nedergaard, Maiken, 30 Dec 2019, bioRxiv, 23 p.

    Research output: Working paperPreprintResearch

  7. Published

    Liver-secreted fluorescent blood plasma markers enable chronic imaging of the microcirculation

    Wang, Xiaowen, Delle, Christine, Asiminas, Antonios, Akther, S., Vittani, Marta, Brøgger, Peter, Kusk, P., Vo, C. T., Radovanovic, Tessa, Konno, A., Hirai, H., Fukuda, M., Weikop, Pia, Goldman, Steven Alan, Nedergaard, Maiken & Hirase, Hajime, 2022, In: Cell Reports Methods. 2, 10, 16 p., 100302.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice

    Wang, Y., Zhao, Z., Rege, S. V., Wang, M., Si, G., Zhou, Y., Wang, S., Griffin, J. H., Goldman, Steven Alan & Zlokovic, B. V., Sep 2016, In: Nature Medicine. 22, 9, p. 1050-1055 6 p.

    Research output: Contribution to journalLetterResearchpeer-review

  9. Published

    Perivascular spaces in the brain: anatomy, physiology and pathology

    Wardlaw, J. M., Benveniste, H., Nedergaard, Maiken, Zlokovic, B. V., Mestre, H., Lee, H., Doubal, F. N., Brown, R., Ramirez, J., MacIntosh, B. J., Tannenbaum, A., Ballerini, L., Rungta, R. L., Boido, D., Sweeney, M., Montagne, A., Charpak, S., Joutel, A., Smith, K. J. & Black, S. E., 2020, In: Nature Reviews. Neurology. 16, p. 137-153 17 p.

    Research output: Contribution to journalReviewResearchpeer-review

  10. Published

    Reply to: Rethink the classical view of cerebrospinal fluid production

    Wardlaw, J. M., Benveniste, H., Nedergaard, Maiken, Zlokovic, B. V., Charpak, S., Smith, K. J. & Black, S. E., 2021, In: Nature Reviews Neurology. 17, 9, p. 590-591

    Research output: Contribution to journalLetterResearchpeer-review

  11. Published

    Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation

    Wei, H. S., Kang, H., Rasheed, I. D., Zhou, S., Lou, N., Gershteyn, A., McConnell, E. D., Wang, Y., Richardson, K. E., Palmer, A. F., Xu, C., Wan, J. & Nedergaard, Maiken, 17 Aug 2016, In: Neuron. 91, 4, p. 851-862 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    The Acute and Chronic Effects of Acetazolamide and Topiramate on Intracranial Pressure and CSF Secretion

    Westgate, C., Kamp-Jensen, C., Israelsen, I., Toft-Bertelsen, Trine Lisberg, Wardman, Jonathan Henry, Jensen, C., Styrishave, Bjarne, MacAulay, Nanna, Jensen, Rasmus Herlo Beenfeldt & Eftekhari, S., 2022, In: Journal of Headache and Pain. 23, Suppl. 1, 1 p., P218.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  13. Published

    A competitive advantage by neonatally engrafted human glial progenitors yields mice whose brains are chimeric for human glia

    Windrem, M. S., Schanz, S. J., Morrow, C., Munir, J., Chandler-Militello, D., Wang, S. & Goldman, Steven Alan, 26 Nov 2014, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 34, 48, p. 16153-61 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Human Glial Progenitor Cells Effectively Remyelinate the Demyelinated Adult Brain

    Windrem, M. S., Schanz, S. J., Zou, L., Chandler-Militello, D., Kuypers, N. J., Nedergaard, Maiken, Lu, Y., Mariani, J. N. & Goldman, Steven Alan, 2020, In: Cell Reports. 31, 7, 23 p., 107658.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia

    Windrem, M. S., Osipovitch, M., Liu, Z., Bates, J., Chandler-Militello, D., Zou, L., Munir, J., Schanz, S., McCoy, K., Miller, R. H., Wang, S., Nedergaard, Maiken, Findling, R. L., Tesar, P. J. & Goldman, Steven Alan, 3 Aug 2017, In: Cell Stem Cell. 21, 2, p. 195-208.e6

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    The effect of long-duration spaceflight on perivascular spaces within the brain

    Wostyn, P., Mader, T. H., Gibson, C. R. & Nedergaard, Maiken, 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 32, 1 p., e2207724119.

    Research output: Contribution to journalLetterResearchpeer-review

  17. Published

    Does Long-Duration Exposure to Microgravity Lead to Dysregulation of the Brain and Ocular Glymphatic Systems?

    Wostyn, P., Mader, T. H., Gibson, C. R. & Nedergaard, Maiken, 2022, In: Eye and Brain. 14, p. 49-58 10 p.

    Research output: Contribution to journalReviewResearchpeer-review

  18. Published

    Glymphatic system and Spaceflight Associated Neuro-Ocular Syndrome

    Wostyn, P. & Nedergaard, Maiken, 2022, Spaceflight Associated Neuro-Ocular Syndrome. Elsevier, p. 67-76 10 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  19. Published

    Pioglitazone reversed the fructose-programmed astrocytic glycolysis and oxidative phosphorylation of female rat offspring

    Wu, C., Hung, C., Hirase, Hajime, Tain, Y., Lee, W., Chan, J. Y. H., Fu, M., Chen, L., Liu, W., Liang, C., Ho, Y., Kung, Y. C., Leu, S. & Wu, K. L. H., 2019, In: American Journal of Physiology: Endocrinology and Metabolism. 316, 4, p. E622-E634

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Butyrate reduction and HDAC4 increase underlie maternal high fructose-induced metabolic dysfunction in hippocampal astrocytes in female rats

    Wu, K. L. H., Liu, W. C., Wu, C. W., Fu, M. H., Huang, H. M., Tain, Y. L., Liang, C. K., Hung, C. Y., Chen, I. C., Hung, P. L., Lin, Y. J. & Hirase, Hajime, 2024, In: Journal of Nutritional Biochemistry. 126, 14 p., 109571.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    A sensitive and specific genetically-encoded potassium ion biosensor for in vivo applications across the tree of life

    Wu, S-Y., Wen, Y., Serre, N. B. C., Laursen, C. C. H., Dietz, A. G., Taylor, B. R., Drobizhev, M., Molina, R. S., Aggarwal, A., Rancic, V., Becker, M., Ballanyi, K., Podgorski, K., Hirase, H., Nedergaard, M., Fendrych, M., Lemieux, M. J., Eberl, D. F., Kay, A. R., Campbell, R. E. & 1 others, Shen, Y., 2023, In: PLOS Biology. 20, 9, 23 p., e3001772.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Comparative analysis of monoaminergic cerebrospinal fluid-contacting cells in Osteichthyes (bony vertebrates)

    L R Xavier, Anna , Fontaine, R., Bloch, S., Affaticati, P., Jenett, A., Demarque, M., Vernier, P. & Yamamoto, K., Jun 2017, In: Journal of Comparative Neurology. 525, 9, p. 2265-2283 19 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Cannula Implantation into the Cisterna Magna of Rodents

    L R Xavier, Anna , Hauglund, Natalie Linea, Holstein-Rønsbo, Stephanie, Li, Q., Sanggaard, S., Lou, N., Lundgaard, I. & Nedergaard, Maiken, 2018, In: Journal of Visualized Experiments. 135, 6 p., e57378.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Enriched environment enhances β-adrenergic signaling to prevent microglia inflammation by amyloid-β

    Xu, H., Rajsombath, M. M., Weikop, Pia & Selkoe, D. J., 2018, In: EMBO Molecular Medicine. 10, 9, 17 p., e8931.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Optimal Self-Induced Stochastic Resonance in Multiplex Neural Networks: Electrical vs. Chemical Synapses

    Yamakou, M. E., Hjorth, P. G. & Martens, E. A., 2020, In: Frontiers in Computational Neuroscience. 14, 18 p., 62.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    A community-based transcriptomics classification and nomenclature of neocortical cell types

    Yuste, R., Hawrylycz, M., Aalling, N., Aguilar-valles, A., Arendt, D., Arnedillo, R. A., Ascoli, G. A., Bielza, C., Bokharaie, V., Bergmann, T. B., Bystron, I., Capogna, M., Chang, Y., Clemens, A., De Kock, C. P. J., Defelipe, J., Dos Santos, S. E., Dunville, K., Feldmeyer, D., Fiáth, R. & 53 others, Fishell, G. J., Foggetti, A., Gao, X., Ghaderi, P., Goriounova, N. A., Güntürkün, O., Hagihara, K., Hall, Vanessa Jane, Helmstaedter, M., Herculano, S., Hilscher, M. M., Hirase, Hajime, Hjerling-leffler, J., Hodge, R., Huang, J., Huda, R., Khodosevich, Konstantin, Kiehn, Ole, Koch, H., Kuebler, E. S., Kühnemund, M., Larrañaga, P., Lelieveldt, B., Louth, E. L., Lui, J. H., Mansvelder, H. D., Marin, O., Martinez-trujillo, J., Moradi Chameh, H., Nath, A., Nedergaard, M., Němec, P., Ofer, N., Pfisterer, U. G., Pontes, S., Redmond, W., Rossier, J., Sanes, J. R., Scheuermann, R., Serrano-saiz, E., Steiger, J. F., Somogyi, P., Tamás, G., Tolias, A. S., Tosches, M. A., García, M. T., Vieira, H. M., Wozny, C., Wuttke, T. V., Yong, L., Yuan, J., Zeng, H. & Lein, E., 2020, In: Nature Neuroscience. 23, p. 1456-1468 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Loss of calretinin and parvalbumin positive interneurones in the hippocampal CA1 of aged Alzheimer's disease mice

    Zallo, F., Gardenal, E., Verkhratsky, A. & Rodríguez, J. J., 2018, In: Neuroscience Letters. 681, p. 19-25 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    The Zika Virus Capsid Disrupts Corticogenesis by Suppressing Dicer Activity and miRNA Biogenesis

    Zeng, J., Dong, S., Luo, Z., Xie, X., Fu, B., Li, P., Liu, C., Yang, X., Chen, Y., Wang, X., Liu, Z., Wu, J., Yan, Y., Wang, F., Chen, J. F., Zhang, J., Long, G., Goldman, S. A., Li, S., Zhao, Z. & 1 others, Liang, Q., 1 Oct 2020, In: Cell Stem Cell. 27, 4, p. 618-632.e9

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Astrogliopathology in the infectious insults of the brain

    Zorec, R., Županc, T. A. & Verkhratsky, A., 2019, In: Neuroscience Letters. 689, p. 56-62 7 p.

    Research output: Contribution to journalReviewResearchpeer-review

  30. Published

    Using crystallography tools to improve vaccine formulations

    de Abreu Fantini, M. C., Pinto Oliveira, C. L., de Souza Lopes, J. L., Martins, T. D. S., Akamatsu, M. A., Trezena, A. G., Tino-De-Franco, M., Botosso, V. F., Brazil Esteves Sant'Anna, O. A., Kardjilov, N., Rasmussen, Martin Kaag & Nunes Bordallo, Heloisa, 1 Jan 2022, In: IUCrJ. 9, p. 11-20 14 p.

    Research output: Contribution to journalReviewResearchpeer-review

  31. E-pub ahead of print

    Human brain clearance imaging: Pathways taken by magnetic resonance imaging contrast agents after administration in cerebrospinal fluid and blood

    van Osch, M. J. P., Wåhlin, A., Scheyhing, P., Mossige, I., Hirschler, L., Eklund, A., Mogensen, K., Gomolka, Ryszard Stefan, Radbruch, A., Qvarlander, S., Decker, A., Nedergaard, Maiken, Mori, Yuki, Eide, P. K., Deike, K. & Ringstad, G., 2024, (E-pub ahead of print) In: NMR in Biomedicine.

    Research output: Contribution to journalReviewResearchpeer-review

  32. Published

    Voluntary running enhances glymphatic influx in awake behaving, young mice

    Holstein-Rønsbo, Stephanie, Petersen, Nicolas Caesar & Nedergaard, Maiken, 2018, In: Neuroscience Letters. 662, p. 253-258 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Fibroblast growth factor 21: an endocrine inhibitor of sugar and alcohol appetite

    Holstein-Rønsbo, Stephanie & Gillum, M. P., 2019, In: The Journal of Physiology. 597, 14, p. 3539-3548 10 p.

    Research output: Contribution to journalReviewResearchpeer-review

  34. Published

    Cerebral glycogen in humans following acute and recurrent hypoglycemia: Implications on a role in hypoglycemia unawareness

    Öz, G., DiNuzzo, M., Kumar, A., Moheet, A., Khowaja, A., Kubisiak, K., Eberly, L. E. & Seaquist, E. R., 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 8, p. 2883-2893 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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